Susan J. Mandel, M.D., M.P.H.
Sylvan H. Eisman Professor of Medicine II
Director, Thyroid Nodule Clinic, Hospital of the University of Pennsylvania
Director, Endocrinology elective for Primary Care Medical Residents
Member, Abramson Cancer Center
Chief, Division of Endocrinology, Diabetes, and Metabolism
Department: Medicine
Contact information
Division of Endocrinology, Diabetes and Metabolism
Perelman School of Medicine, University of Pennsylvania
4th floor West, Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Perelman School of Medicine, University of Pennsylvania
4th floor West, Perelman Center for Advanced Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Education:
A.B. (History of Science)
Harvard University, Cambridge, MA, 1982.
M.D.
Columbia University, College of Physicians and Surgeons, New York, NY, 1986.
M.P.H. (Quantitative methods, decision analysis)
Harvard School of Public Health, Boston, MA, 1997.
Permanent linkA.B. (History of Science)
Harvard University, Cambridge, MA, 1982.
M.D.
Columbia University, College of Physicians and Surgeons, New York, NY, 1986.
M.P.H. (Quantitative methods, decision analysis)
Harvard School of Public Health, Boston, MA, 1997.
Description of Research Expertise
Thyroid nodules, Thyroid cancer, Thyroid disease and pregnancy, UltrasoundDescription of Clinical Expertise
Thyroid nodules, Thyroid cancer, Thyroid disease and pregnancy, UltrasoundDr. Susan J. Mandel, MD, MPH is a Professor of Medicine and Radiology and Chief of the Division of Endocrinology, Diabetes and Metabolism at the Perelman School of Medicine, University of Pennsylvania where she directed the Endocrine fellowship for 22 years. After medical school at the College of Physicians and Surgeons, she completed a medical residency at Columbia Presbyterian Medical Center and a fellowship in endocrinology at the Brigham and Women's. Her clinical practice focuses on patients with thyroid neoplasia and she has been recognized for clinical excellence with the Penn Duhring Clinical Specialist award. Her research interests include the use of sonography in the evaluation of patients with thyroid nodules and cancer, and thyroid disease during pregnancy. Dr. Mandel has over 80 peer reviewed publications in journals including the New England Journal of Medicine, JAMA and the Annals of Internal Medicine. She has also authored chapters on thyroid disorders in Harrison’s Textbook of Medicine and thyroid nodules in Werner and Ingbar’s The Thyroid.
Dr. Mandel has served on the writing groups for the American Thyroid Association (ATA) Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer and the Management of Thyroid Disease during Pregnancy. She is currently co-chairing the 2022 ATA Management Guidelines for Patients with Thyroid nodules. Dr. Mandel also initiated and directed the Ultrasound workshops for the ATA and Endocrine Society. Dr. Mandel has received the Endocrine Society's Distinguished Educator Award, the 2019 WIT Woman of the Year award from the ATA and the H. Jack Baskin Educator Award of the American Association of Clinical Endocrinologists. She is past President of the Endocrine Society, as well as past President of the Association of Program Directors in Endocrinology, Diabetes, and Metabolism.
Selected Publications
Nachum S, Tondi Resta I, Baloch Z, Mandel SJ: Thyroid Nodules with Indeterminate Cytology and Negative Molecular Profile: Prevalence of Malignancy and Practice Paradigms for Surveillance. Thyroid Jan 2025 Notes: doi: 10.1089/thy.2024.0455. Epub ahead of print.Ginzberg SP, Sharpe J, Passman JE, Amjad W, Wirtalla CJ, Soegaard Ballester JM, Finn CB, Mandel SJ, Kelz RR, Wachtel H.: Revisiting the Relationship Between Tumor Size and Risk in Well-Differentiated Thyroid Cance. Thyroid 34(8): 980-989, Aug 2024. Notes: doi: 10.1089/thy.2023.0327. Epub 2024 Jul 24.
Alexis M, Ginzberg SP, Soegaard Ballester JM, Mandel SJ, Langer JE, Kelz RR, Wachtel H.: Assessing the Frequency of Deferrable Thyroid Nodule Biopsies to De- escalate Low-Value Care. Endocr Pract. 30(4): 305-310, Apr 2024 Notes: doi: 10.1016/j.eprac.2023.
Grani G, Del Gatto V, Cantisani V, Mandel SJ, Durante C.: A Reappraisal of Suspicious Sonographic Features of Thyroid Nodules: Shape Is Not an Independent Predictor of Malignancy. J Clin Endocrinol Metab 108: e816-e822, Aug 2023.
Durante C, Hegedüs L, Na DG, Papini E, Sipos JA, Baek JH, Frasoldati A, Grani G, Grant E, Horvath E, Hoang JK, Mandel SJ, Middleton WD, Ngu R, Orloff LA, Shin JH, Trimboli P, Yoon JH, Tessler FN.: International Expert Consensus on US Lexicon for Thyroid Nodules. Radiology 2023.
Ginzberg SP, Soegaard Ballester JM, Wirtalla CJ, Morales KH, Pryma DA, Mandel SJ, Kelz RR, Wachtel H.: Racial and Ethnic Disparities in Appropriate Thyroid Cancer Treatment, Before and After the Release of the 2015 American Thyroid Association Guidelines. Ann Surg Oncol 2023.
Ginzberg SP, Soegaard Ballester JM, Wirtalla CJ, Morales KH, Pryma DA, Mandel SJ, Kelz RR, Wachtel H.: ASO Visual Abstract: Racial and Ethnic Disparities in Appropriate Thyroid Cancer Treatment, Before and After the Release of the 2015 American Thyroid Association Guidelines. Ann Surg Oncol 2023.
Andrianus S, Gubbiotti MA, Mandel SJ, Nikiforov YE, Baloch Z.: Unraveling the significance of TSHR mutations in indeterminate thyroid cytology specimens. Diagn Cytopathol 2023.
Ginzberg SP, Soegaard Ballester JM, Wirtalla CJ, Pryma DA, Mandel SJ, Kelz RR, Wachtel H.: Insurance-Based Disparities in Guideline-Concordant Thyroid Cancer Care in the Era of De-escalation. J Surg Res 2023.
Chou R, Dana T, Mayson SE, Cibas ES, Durante C, Solórzano CC, Mandel SJ, Orloff LA.: Ultrasound Follow-Up of Benign Thyroid Nodules: A Scoping Review. Thyroid 2023.