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Douglas B. Cines, M.D.
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Professor of Pathology and Laboratory Medicine
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Department: Pathology and Laboratory Medicine
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Contact information
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Dept. Pathology and Laboratory Medicine
1c 513 A Stellar Chance
17 422 Curie Blvd.
3e University of Pennsylvania
Philadelphia, PA 19104
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1c 513 A Stellar Chance
17 422 Curie Blvd.
3e University of Pennsylvania
Philadelphia, PA 19104
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Office: 215-662-3966
32 Fax: 215-573-2012
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32 Fax: 215-573-2012
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Publications
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Links
e2 Search PubMed for articles
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Education:
21 9 A.B. 1c (History, PreMed) c
2c New York University, 1968.
21 9 M.D. 15 (Medicine) c
3f New York University School of Medicine, 1972.
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Permanent link21 9 A.B. 1c (History, PreMed) c
2c New York University, 1968.
21 9 M.D. 15 (Medicine) c
3f New York University School of Medicine, 1972.
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Description of Research Expertise
4c Thormbosis, fibrinolysis, vascular biology, immunohematology65
Description of Clinical Expertise
3b Coagulation. Immune hematological disorders1a 29
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117 Myoung S, Francis SJ, Chen J, Lee G, Rauova L, Poncz M, Cines DB, Kuchibhatla M, Khandelwal S, Arepally GM. : Complement Activation as a biomarker for platelet activating HIT antibodies. ASH 2024. ASH 2024.
11c Field CO, Sarkar A, Bdeir Kh, McRae KR, Ortel TL, Kowalska MA, Rauova L, Cines DB, Gollomp K, Poncz M. : Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder. ASH 2024.
11f Rauova L, Oberg J, Gilbert S, Cines DB, Poncz M. : A murine model of vaccine-induced immune thrombotic thrombocytopenia (VITT) leads to anti-NAP2 and anti-PF4 antibodies and may involve TLR9 activation. ISTH 2024.
186 Ngo ATP, Skidmore A, Yarovoi I, Sarkar A, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K.: Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. JCI-Insight. 8(22), November 2023.
b6 Bussel JM, Hou M, Cines DB.: Management of primary ITP in pregnancy. New Eng J Med. 389(6): 540, August 2023.
139 Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M.: Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Adv May 2023.
b5 Cines DB, Greinacher A.: Vaccine-induced immune thrombotic thrombocytopenia. Blood 141: 1659-1665, Apr 2023.
12c Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB.: Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. J Thromb Haemost 2023.
156 Rauova L, Oberg J, Field C, Levine N, Arepally HM, Cines DB, Cohen T, Poncz M: ChadOx exposure-induced neutrophil-activating peptide 2 (NAP2) antibodies: Murine-based insights into the pathgenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT). ISTH 2023.
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Selected Publications
166 Sarkar A, Yadav SK, Field CO, Gollomp K, McCrae KM, Ortel T, Gruel Y, Rollen J, Arepally GM, Rauova L, Cines DB, Poncz M. : Anti-phospholipid syndrome (APS) antibody (Ab)-induced thrombosis can be blocked by platelet factor 4 (PF4)-directed Abs: A novel therapeutic for APS? ASH 2024.117 Myoung S, Francis SJ, Chen J, Lee G, Rauova L, Poncz M, Cines DB, Kuchibhatla M, Khandelwal S, Arepally GM. : Complement Activation as a biomarker for platelet activating HIT antibodies. ASH 2024. ASH 2024.
11c Field CO, Sarkar A, Bdeir Kh, McRae KR, Ortel TL, Kowalska MA, Rauova L, Cines DB, Gollomp K, Poncz M. : Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder. ASH 2024.
11f Rauova L, Oberg J, Gilbert S, Cines DB, Poncz M. : A murine model of vaccine-induced immune thrombotic thrombocytopenia (VITT) leads to anti-NAP2 and anti-PF4 antibodies and may involve TLR9 activation. ISTH 2024.
186 Ngo ATP, Skidmore A, Yarovoi I, Sarkar A, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K.: Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. JCI-Insight. 8(22), November 2023.
b6 Bussel JM, Hou M, Cines DB.: Management of primary ITP in pregnancy. New Eng J Med. 389(6): 540, August 2023.
139 Sarkar A, Khandelwal S, Koma G, Kim H, Gruel Y, Rollin J, Passam FH, Wool GD, Arepally GM, Cines DB, Rauova L, Poncz M.: Prevention of thrombocytopenia and thrombosis in HIT using deglycosylated KKO: a novel therapeutic? Blood Adv May 2023.
b5 Cines DB, Greinacher A.: Vaccine-induced immune thrombotic thrombocytopenia. Blood 141: 1659-1665, Apr 2023.
12c Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB.: Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. J Thromb Haemost 2023.
156 Rauova L, Oberg J, Field C, Levine N, Arepally HM, Cines DB, Cohen T, Poncz M: ChadOx exposure-induced neutrophil-activating peptide 2 (NAP2) antibodies: Murine-based insights into the pathgenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT). ISTH 2023.
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