Jaclyn A. Biegel, Ph.D.

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Emeritus Professor CE of Pediatrics
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
3615 Civic Center Boulevard, RM 716C ARC Bldg.
Philadelphia, PA 19104
Office: 215-590-3856
Fax: 215-590-2156
Lab: 215-590-5257
B.S. (Biology)
Union College, 1977.
M.S. (Human Genetics)
University of Pittsburgh, 1979.
Ph.D. (Human Genetics)
University of Pittsburgh, 1981.
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Description of Research Expertise

cancer cytogenetics
rhabdoid tumor
genetics of pediatric brain tumors

Description of Clinical Expertise

cancer cytogenetics

Selected Publications

Jackson, E.M., Sievert, A.J., Gai, X., Hakonarson, H., Judkins, A.R., Tooke, L., Perin, J.C., Xie, H., Shaikh, T.H., Biegel, J.A.: Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors. Clin Cancer Res. 15(15): 1923-1930, 6 2009.

Biegel JA., Zhou JY., Rorke LB., Stenstrom C., Wainwright LM., Fogelgren B.: Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Research 59(1): 74-79, Jan 1 1999.

Sievert, A.J., Jackson, E.M., Gai, X., Hakonarson, H., Judkins, A.R., Resnick, A.C., Sutton, L.N., Storm, P.B., Shaikh, T.H. and Biegel, J.A. : Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathology 19: 449-458, 2009.

Judkins AR., Mauger J., Rorke LB., Biegel JA.: Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms. American Journal of Surgical Pathology 28(5): 644-650, May 2004.

Biegel JA.: Cytogenetics and molecular genetics of childhood brain tumors. Neuro-Oncology 1(2): 139-152, Apr 1999.

Swensen, J.J., Keyser, J., Coffin, C.M., Biegel, J.A., Viskochil, D.H., and Williams, M.S.: Familial occurrence of schwannomas and malignant rhabdoid tumor associated with a duplication in SMARCB1. J. Med. Genet. 44: 68-72, 2009.

Jackson, E.M. , Shaikh, T.H., Gururangan, S., Jones, M.C., Malkin, D., Nikkel, S.M., Zuppan, C.W., Wainwright, L.M., Zhang, F., Biegel, J.A.: High-density single nucleotide polymorphism array analysis in patients with germline deletions of 22q11.2 and malignant rhabdoid tumor. Human Genet 122: 117-127, 2007.

Wu, Y., Lun, X., Zhou, H., Wang, L., Sun, B., Bell, J.C., Barrett, J.W., McFadden, G., Biegel, J.A., Senger, D.L., Forsyth, P.A.: Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors. Clinical Cancer Research 14: 1218-1227, 2008.

Pan, E., Pellarin, M., Holmes, E., Smirnov, I., Misra, A., Eberhart, C.G., Burger, P.C., Biegel, J.A., Feuerstein, B. G.: Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin Cancer Res 11(13): 4733-4740, 2005.

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Last updated: 12/03/2014
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