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David E. Pleasure
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Emeritus Professor of Neurology
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Department: Neurology
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Contact information
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517, Abramson Research Center
31 The Children’s Hospital of Philadelphia
3f 3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
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31 The Children’s Hospital of Philadelphia
3f 3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
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Office: 215 590-2090
32 Fax: 215 590-3709
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32 Fax: 215 590-3709
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Email:
PLEASURE@EMAIL.CHOP.EDU
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PLEASURE@EMAIL.CHOP.EDU
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Publications
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Links
99 Search PubMed for articles
44 Pharmacological Sciences graduate group faculty webpage.
46 Cell and Molecular Biology graduate group faculty webpage.
41 Neuroscience graduate group faculty webpage.
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99 Search PubMed for articles
44 Pharmacological Sciences graduate group faculty webpage.
46 Cell and Molecular Biology graduate group faculty webpage.
41 Neuroscience graduate group faculty webpage.
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Education:
21 9 B.A. 14 (History) c
25 Yale College, 1959.
21 9 M.D. c
2c Columbia University, 1963.
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Permanent link21 9 B.A. 14 (History) c
25 Yale College, 1959.
21 9 M.D. c
2c Columbia University, 1963.
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65 oligodendroglial development, oligodendroglial excitotoxicity, peripheral nerve regeneration
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80 Key words: oligodendroglia, Schwann cells, excitotoxicity, multiple sclerosis, periventricular leukomalacia, neuropilin.
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1f DESCRIPTION OF RESEARCH
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29 We are addressing two questions:
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a5 1. what mechanisms are responsible for the death of oligodendroglia in infants with periventricular leukomalacia, and in adults with multiple sclerosis; and
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c1 2. what factors control the success of peripheral nerve regeneration. Methods include cell culture, genetically modified mice, and molecular/ immunochemical/ immunohistological analyses.
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Description of Research Expertise
24 RESEARCH INTERESTS8
65 oligodendroglial development, oligodendroglial excitotoxicity, peripheral nerve regeneration
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80 Key words: oligodendroglia, Schwann cells, excitotoxicity, multiple sclerosis, periventricular leukomalacia, neuropilin.
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1f DESCRIPTION OF RESEARCH
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29 We are addressing two questions:
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a5 1. what mechanisms are responsible for the death of oligodendroglia in infants with periventricular leukomalacia, and in adults with multiple sclerosis; and
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c1 2. what factors control the success of peripheral nerve regeneration. Methods include cell culture, genetically modified mice, and molecular/ immunochemical/ immunohistological analyses.
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Selected Publications
e0 Itoh (T), Itoh (A), and Pleasure: Bcl-2-related protein family gene expression during oligodendroglial differentiation. J Neurochem 85: 1500-12, 2003.2c