David E. Pleasure
Emeritus Professor of Neurology
Department: Neurology
Contact information
517, Abramson Research Center
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: 215 590-2090
Fax: 215 590-3709
Fax: 215 590-3709
Email:
PLEASURE@EMAIL.CHOP.EDU
PLEASURE@EMAIL.CHOP.EDU
Publications
Links
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Neuroscience graduate group faculty webpage.
Pharmacological Sciences graduate group faculty webpage.
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Neuroscience graduate group faculty webpage.
Pharmacological Sciences graduate group faculty webpage.
Education:
B.A. (History)
Yale College, 1959.
M.D.
Columbia University, 1963.
Permanent linkB.A. (History)
Yale College, 1959.
M.D.
Columbia University, 1963.
Description of Research Expertise
RESEARCH INTERESTSoligodendroglial development, oligodendroglial excitotoxicity, peripheral nerve regeneration
Key words: oligodendroglia, Schwann cells, excitotoxicity, multiple sclerosis, periventricular leukomalacia, neuropilin.
DESCRIPTION OF RESEARCH
We are addressing two questions:
1. what mechanisms are responsible for the death of oligodendroglia in infants with periventricular leukomalacia, and in adults with multiple sclerosis; and
2. what factors control the success of peripheral nerve regeneration. Methods include cell culture, genetically modified mice, and molecular/ immunochemical/ immunohistological analyses.