David E. Pleasure

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Emeritus Professor of Neurology
Department: Neurology

Contact information
517, Abramson Research Center
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318
Office: 215 590-2090
Fax: 215 590-3709
B.A. (History)
Yale College, 1959.
Columbia University, 1963.
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Description of Research Expertise


oligodendroglial development, oligodendroglial excitotoxicity, peripheral nerve regeneration

Key words: oligodendroglia, Schwann cells, excitotoxicity, multiple sclerosis, periventricular leukomalacia, neuropilin.


We are addressing two questions:

1. what mechanisms are responsible for the death of oligodendroglia in infants with periventricular leukomalacia, and in adults with multiple sclerosis; and

2. what factors control the success of peripheral nerve regeneration. Methods include cell culture, genetically modified mice, and molecular/ immunochemical/ immunohistological analyses.

Selected Publications

Itoh (T), Itoh (A), and Pleasure: Bcl-2-related protein family gene expression during oligodendroglial differentiation. J Neurochem 85: 1500-12, 2003.

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Last updated: 09/09/2004
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