Lynn Mara Schuchter, M.D.

faculty photo
Madlyn and Leonard Abramson Professor of Clinical Oncology
Attending Physician, Hospital of the University of Pennsylvania
Internal Advisory Board Member, University of Pennsylvania Center for Health Incentives and Behavioral Economics
Internal Advisory Board Member , Palliative and Advanced Illness Research Center (PAIR)
Director, Tara Miller Melanoma Center, Abramson Cancer Center
Department: Medicine

Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
3rd Floor, South Pavilion
Office #3-300
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-662-3011
Education:
B.S.
University of Michigan, 1978.
M.D.
Chicago Medical School, 1982.
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Selected Publications

Ravi B Parikh, Emily Schriver, William J Ferrell, Jonathan Wakim, Joelle Williamson, Neda Khan, Michael Kopinsky, Mohan Balachandran, Peter E Gabriel, Lynn M Schuchter, Mitesh S Patel, Lawrence N Shulman, Christopher R Manz : Remote Patient-Reported Outcomes and Activity Monitoring to Improve Patient-Clinician Communication Regarding Symptoms and Functional Status: A Randomized Controlled Trial. JCO Oncol Pract October 2023.

Sarah A Weiss, Mario Sznol, Montaser Shaheen, Miguel-Angel Berciano-Guerrero, Eva Muñoz-Couselo, Delvys Rodríguez-Abreu, Valentina Boni, Lynn M Schuchter, Maria Gonzalez Cao, Ana Arance Fernandez, Wei Wei, Apar Kishor Ganti, Ralph J Hauke, Alfonso Berrocal, Nicholas O Iannotti, Frank J Hsu, Harriet M Kluge: A Phase II Trial of the CD40 Agonist Sotigalimab (APX005M) in Combination with Nivolumab in Subjects with Metastatic Melanoma with Disease Progression on Anti-PD-1. Clin Cancer Res August 2023.

Lingling Ou, Shujing Liu, Huaishan Wang, Yeye Guo, Lei Guan, Longbin Shen, Ruhui Luo, David E Elder, Alexander C Huang, Giorgos Karakousis, John Miura, Tara Mitchell, Lynn Schuchter, Ravi Amaravadi, Ahron Flowers, Haiwei Mou, Fan Yi, Wei Guo, Jina Ko, Qing Chen, Bin Tian, Meenhard Herlyn, Xiaowei Xu : Patient-derived melanoma organoid models facilitate the assessment of immunotherapies. EBioMedicine June 2023.

Payal D Shah, Alexander C Huang, Xiaowei Xu, Robert Orlowski, Ravi K Amaravadi, Lynn M Schuchter, Paul Zhang, Julia Tchou, Tina Matlawski, Amanda Cervini, Joanne Shea, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, E John Wherry, Gerald P Linette, Andrea Brennan, Vanessa Gonzalez, Irina Kulikovskaya, Simon F Lacey, Gabriela Plesa, Carl H June, Robert H Vonderheide, Tara C Mitchell : Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma. Cancer Res Commun May 2023.

Christopher R Manz, Yichen Zhang, Kan Chen, Qi Long, Dylan S Small, Chalanda N Evans, Corey Chivers, Susan H Regli, C William Hanson, Justin E Bekelman, Jennifer Braun, Charles A L Rareshide, Nina O'Connor, Pallavi Kumar, Lynn M Schuchter, Lawrence N Shulman, Mitesh S Patel, Ravi B Parikh: Long-term Effect of Machine Learning-Triggered Behavioral Nudges on Serious Illness Conversations and End-of-Life Outcomes Among Patients With Cancer: A Randomized Clinical Trial. JAMA Oncol March 2023.

Evgenii N Tcyganov, Emilio Sanseviero, Douglas Marvel, Thomas Beer, Hsin-Yao Tang, Peter Hembach, David W Speicher, Qianfei Zhang, Laxminarasimha R Donthireddy, Ali Mostafa, Sabina Tsyganova, Vladimir Pisarev, Terri Laufer, Dmitriy Ignatov, Soldano Ferrone, Christiane Meyer, Hélène Maby-El Hajjami, Daniel E Speiser, Sooner Altiok, Scott Antonia, Xiaowei Xu, Wei Xu, Cathy Zheng, Lynn M Schuchter, Ravi K Amaravadi, Tara C Mitchell, Giorgos C Karakousis, Zhe Yuan, Luis J Montaner, Esteban Celis, Dmitry I Gabrilovich : Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy. Cancer Cell October 2022.

Emily J Anstadt, Brian Chu, Nikhil Yegya-Raman, Xiaoyan Han, Abigail Doucette, Kendra Poirier, Jahan J Mohiuddin, Amit Maity, Andrea Facciabene, Ravi K Amaravadi, Giorgos C Karakousis, Justine V Cohen, Tara C Mitchell, Lynn M Schuchter, John N Lukens: Moderate Colitis Not Requiring Intravenous Steroids Is Associated with Improved Survival in Stage IV Melanoma after Anti-CTLA4 Monotherapy, But Not Combination Therapy. The Oncologist. Oxford University Press, 27: 799-808, September 2022.

Ramin Sedaghat Herati, David A Knorr, Laura A Vella, Luisa Victoria Silva, Lakshmi Chilukuri, Sokratis A Apostolidis, Alexander C Huang, Alexander Muselman, Sasikanth Manne, Oliva Kuthuru, Ryan P Staupe, Sharon A Adamski, Senthil Kannan, Raj K Kurupati, Hildegund CJ Ertl, Jeffrey L Wong, Stylianos Bournazos, Suzanne McGettigan, Lynn M Schuchter, Ritesh R Kotecha, Samuel A Funt, Martin H Voss, Robert J Motzer, Chung-Han Lee, Dean F Bajorin, Tara C Mitchell, Jeffrey V Ravetch, E John Wherry: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine. Nature Immunology August 2022.

Lei Guan, Bin Wu, Ting Li, Lynn A Beer, Gaurav Sharma, Mingyue Li, Chin Nien Lee, Shujing Liu, Changsong Yang, Lili Huang, Dennie T Frederick, Genevieve M Boland, Guangcan Shao, Tatyana M Svitkina, Kathy Q Cai, Fangping Chen, Meng-Qiu Dong, Gordon B Mills, Lynn M Schuchter, Giorgos C Karakousis, Tara C Mitchell, Keith T Flaherty, David W Speicher, Youhai H Chen, Meenhard Herlyn, Ravi K Amaravadi, Xiaowei Xu, Wei Guo: HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors. Nature communications July 2022.

Lingling Ou, Huaishan Wang, Hui Huang, Zhiyan Zhou, Qiang Lin, Yeye Guo, Tara Mitchell, Alexander C Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Wei Guo, Joseph Salvino, Meenhard Herlyn, Xiaowei Xu: Preclinical platforms to study therapeutic efficacy of human γδ T cells. Clinical and translational medicine June 2022.

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Last updated: 12/05/2023
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