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In Memoriam
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John S. Leigh
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Department: Radiology
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Contact information
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B1, Stellar-Chance Laboratories
37 422 Curie Blvd.
Philadelphia, PA 19104-6100
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37 422 Curie Blvd.
Philadelphia, PA 19104-6100
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Office: (215) 898-2044
34 Fax: (215) 573-2113
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34 Fax: (215) 573-2113
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Email:
JACK@MAIL.MMRRCC.UPENN.EDU
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JACK@MAIL.MMRRCC.UPENN.EDU
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Publications
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Links
112 Search PubMed for articles
56 BMB graduate group faculty webpage.
5a Primary Work Website
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112 Search PubMed for articles
56 BMB graduate group faculty webpage.
5a Primary Work Website
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Education:
21 9 B.Sc 23 (Electrical Engineering) c
33 University of Pennsylvania, 1961.
21 a Ph.D. 17 (Biophysics) c
33 University of Pennsylvania, 1971.
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Permanent link21 9 B.Sc 23 (Electrical Engineering) c
33 University of Pennsylvania, 1961.
21 a Ph.D. 17 (Biophysics) c
33 University of Pennsylvania, 1971.
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18a To develop innovative magnetic resonance (MR) and optical technologies for biomedical research. Many of these technologies are driven by both basic and clinical research collaborators in the biomedical field to address specific clinical problems and to further fundamental understanding of biophysical, physiological, structural, and functional properties of biological systems in vivo.
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e4 To investigate the use of multinuclear MR techniques to study the structural and metabolic properties of cartilage, brain, and muscle, with direct application to osteoarthritis, cognitive funtion, and muscular dystrophy.
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7a To investigate the use of multinuclear MR to monitor, the efficacy of gene therapy and gene expression in general.
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62 To develop and improve quantitative perfusion and diffusion imaging, in comparison to PET.
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fb To develop innovative techniques for quantitative structural imaging of multiple organ systems. These techniques include MR of hyperpolarized gases, novel contrast generation using zero-quantum coherences, and imaging of tissue microstructure.
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90 To focus on combining optical and MR imaging techniques for the study of neurophysiology, peripheral vascular disease, and breast cancer.
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Description of Research Expertise
29 Current Research Topics:8
18a To develop innovative magnetic resonance (MR) and optical technologies for biomedical research. Many of these technologies are driven by both basic and clinical research collaborators in the biomedical field to address specific clinical problems and to further fundamental understanding of biophysical, physiological, structural, and functional properties of biological systems in vivo.
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e4 To investigate the use of multinuclear MR techniques to study the structural and metabolic properties of cartilage, brain, and muscle, with direct application to osteoarthritis, cognitive funtion, and muscular dystrophy.
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7a To investigate the use of multinuclear MR to monitor, the efficacy of gene therapy and gene expression in general.
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62 To develop and improve quantitative perfusion and diffusion imaging, in comparison to PET.
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fb To develop innovative techniques for quantitative structural imaging of multiple organ systems. These techniques include MR of hyperpolarized gases, novel contrast generation using zero-quantum coherences, and imaging of tissue microstructure.
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90 To focus on combining optical and MR imaging techniques for the study of neurophysiology, peripheral vascular disease, and breast cancer.
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105 Tailor, D.R., Baumgardner, J.E., Regatte, R.R., Leigh, J.S., Reddy, R. : Proton MRI of metabolically produced H2 17O using an efficient 17O2 delivery system. Neuroimage 22(2): 611-8, 2004.
d4 Li, L., Leigh, J.S.: Quantifying Arbitrary Magnetic Susceptibility Distributions with Magnetic Resonance. Magn Reson Med 51: 1077-82, 2004.
160 Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M. : Spatio-Temporal Characteristics of the BOLD Signal: Spin-Echo and Gradient-Echo fMRI at 3 T. Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 1056, 2004.
14e Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M. ‘: A Two Compartment Model for Spin Echo BOLD Contrast: Validation at 3 T. Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 1065, 2004.
f3 Li, L., Leigh, J.S.: A General Methodology for Quantifying Magnetic Susceptibility with MRI. Annul Conference of the American Physical Society, Montreal, Canada 03 2004.
129 Rajaei, S., Baumgardnr, J., Ishii, M., Fischer, M., Emami, K., Yu, J., Lipson, D., Gefter, W., Schnall, M.D., Leigh, J.S., Rizi, R.R.: Comparison of Ventilation/Perfusion Obtained by Polarized Gas MRI with Multiple Inert Gas Elimination Technique 8b Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 847, 2004.
117 Tailor DR, Roy A, Regatte RR, Charagundla SR, McLaughlin AC, Leigh JS, and Reddy R: Indirect 17O-Magnetic Resonance Imaging of Cerebral Blood Flow in Rat. Magnetic Resonance in Medicine 49(3): 479-87, 2003.
135 Tailor DR, Poptani H, Glickson JD, Leigh JS, and Reddy R: High-Resolution Assessment of Blood Flow in Murine RIF-1 Tumors by Monitoring Uptake of H217O with Proton T1p-Dispersion Imaging. Magnetic Resonance in Medicine 49(1): 1-6, 2003.
165 Chen, Y., Intes, X., Tailor, D.R., Regatte, R.R., Ma, H., Ntziachristos, V., Leigh, J.S., Reddy, R., Chance, B. : Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI). Advances in Experimental Medicine & Biology 510: 199-20, 2003.
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Selected Publications
139 Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M.A.: Spatial sensitivity and temporal response of spin echo and gradient echo bold contrast at 3 T using peak hemodynamic activation time’ Neuroimage 24(1): 216-23, 2005.105 Tailor, D.R., Baumgardner, J.E., Regatte, R.R., Leigh, J.S., Reddy, R. : Proton MRI of metabolically produced H2 17O using an efficient 17O2 delivery system. Neuroimage 22(2): 611-8, 2004.
d4 Li, L., Leigh, J.S.: Quantifying Arbitrary Magnetic Susceptibility Distributions with Magnetic Resonance. Magn Reson Med 51: 1077-82, 2004.
160 Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M. : Spatio-Temporal Characteristics of the BOLD Signal: Spin-Echo and Gradient-Echo fMRI at 3 T. Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 1056, 2004.
14e Hulvershorn, J., Bloy, L., Gualtieri, E.E., Leigh, J.S., Elliott, M. ‘: A Two Compartment Model for Spin Echo BOLD Contrast: Validation at 3 T. Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 1065, 2004.
f3 Li, L., Leigh, J.S.: A General Methodology for Quantifying Magnetic Susceptibility with MRI. Annul Conference of the American Physical Society, Montreal, Canada 03 2004.
129 Rajaei, S., Baumgardnr, J., Ishii, M., Fischer, M., Emami, K., Yu, J., Lipson, D., Gefter, W., Schnall, M.D., Leigh, J.S., Rizi, R.R.: Comparison of Ventilation/Perfusion Obtained by Polarized Gas MRI with Multiple Inert Gas Elimination Technique 8b Proceedings of the International Society for Magnetic Resonance in Medicine Meeting, Kyoto, Japan Page: 847, 2004.
117 Tailor DR, Roy A, Regatte RR, Charagundla SR, McLaughlin AC, Leigh JS, and Reddy R: Indirect 17O-Magnetic Resonance Imaging of Cerebral Blood Flow in Rat. Magnetic Resonance in Medicine 49(3): 479-87, 2003.
135 Tailor DR, Poptani H, Glickson JD, Leigh JS, and Reddy R: High-Resolution Assessment of Blood Flow in Murine RIF-1 Tumors by Monitoring Uptake of H217O with Proton T1p-Dispersion Imaging. Magnetic Resonance in Medicine 49(1): 1-6, 2003.
165 Chen, Y., Intes, X., Tailor, D.R., Regatte, R.R., Ma, H., Ntziachristos, V., Leigh, J.S., Reddy, R., Chance, B. : Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI). Advances in Experimental Medicine & Biology 510: 199-20, 2003.
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