Glen N. Gaulton, Ph.D.
Perelman School of Medicine
240 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6055
Fax: (215) 573-7945
B.S. (Biology, with honors)
University of California, Santa Barbara, 1974.
Ph.D. (Biochemistry/Molecular Biology)
University of California, Santa Barbara, 1981.
Description of Research ExpertiseResearch Interest
Global Health, Education Program Building, Lymphocyte development and retroviral pathology
Keywords: Lymphocyte Development, Retrovirus Pathology, HIV-1, Imaging, Diagnostics
Molecular genetics, cell biology, imaging, diagnostics, virology, immunology
The interests of the Gaulton laboratory focus on an increased understanding of the molecular processes that regulate the infection and pathology of retroviruses, such as HIV, the impact of these infections on the immune system, and the detection of these infections using novel imaging and diagnostic approaches.
More specifically, the laboratory has investigated the effects of human and, as experimental models, murine retroviruses during active infection of adult, pediatric and neonatal subjects. Recent results have identified the primary mechanisms whereby retroviruses induce cell destruction through cell-cell fusion, also know as syncytia formation. The laboratory has pioneered the use of magnetic resonance imaging (MRI) techniques to detect HIV infection within cells and is now applying these techniques to in vivo, whole body imaging of active infections. Lastly, using state-of-the-art engineering technology, the laboratory is developing highly sensitive yet mobile, hand-held devices to detect HIV infection in blood. These devices are critical for diagnosing new infections, and to monitor HIV levels in patients undergoing active therapy and/or participating in vaccine trials.
Other functions of Dr. Gaulton relate to the planning and oversight of Penn Medicine's world-wide global health programs.
Tomasz Rosmyslowicz,M.D., Sr. Research Investigator
Selected PublicationsLin, G, Murphy, SL, Gaulton, GN, and Hoxie, JA: Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase. Journal of Virology Methods 128(1-2): 135-142, Sep 2005.
Levinson, Al, Song, D, Gaulton, GN, and Zheng: The intrathymic pathogenesis of myasthenia gravis. Clinical Development Immunology 11: 215-220, 2005.
Murphy, SL, Honczarenko, MJ, Dugger, NV, Hoffman, PM, Gaulton, GN: Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR. Journal of Virology 78: 8392 - 8399, 2004.
Chung Landers, M., Dugger, N., Quadros, M., Hoffman, P. M., and Gaulton, G.N.: Neuropathogenic murine leukemia virus TR1.3 induces selective syncytia formation of primary BALB/c brain capillary endothelium. Virology 321: 57-64, 2004.