James M. Metz, M.D.

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Henry K. Pancoast Professor of Radiation Oncology
Department: Radiation Oncology

Contact information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
2 West
Philadelphia, PA 19104
Office: 215-349-5570
Fax: 215-349-5923
BS (Biology)
Juniata College , 1989.
MS (Clinical Immunology/Microbiology)
Hahnemann University , 1991.
MD (Medicine)
UMDNJ-Robert Wood Johnson Med School, 1995.
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Description of Clinical Expertise

Dr. Metz serves as Chair of Radiation Oncology at the Perelman School of Medicine and holds the Henry K. Pancoast Endowed Professorship. He is Associate Director for Clinical Services and Programs at the Abramson Comprehensive Cancer Center of the University of Pennsylvania. Dr. Metz led the development of the Roberts Proton Therapy Center, the largest proton center in the world completely integrated with conventional cancer services. Dr. Metz has become an international leader in the application of proton therapy for the treatment of a variety of malignancies. He continues to work to integrate proton therapy as a new treatment paradigm for cancer and is leading the expansion of proton therapy.

Dr. Metz specializes in the use of radiation for the treatment of gastrointestinal malignancies. His research interests include the treatment of GI malignancies in the multidisciplinary setting, as well as the utilization of complementary and alternative medications by cancer patients, and use of the Internet to provide cancer related information. A major area of interest has been the development of proton therapy at Penn and internationally.

Dr. Metz also serves as Executive Director of OncoLink (www.oncolink.upenn.edu), the award winning Internet resource from the Abramson Comprehensive Cancer Center of the University of Pennsylvania that was founded in 1994. As Executive Director, Dr. Metz leads OncoLink’s mission to help cancer patients, families, health care professionals, and the general public find accurate cancer-related information online. The website has led the way in online education for cancer patients and healthcare providers, receiving numerous awards and recognition from most major authorities as one of the best cancer information websites. Currently OncoLink is developing interactive content and personalized information for individuals while collecting important information to move the field forward, particularly in the area of cancer survivorship. Its reach is international in scope with over 285,000 unique visitors served per month.

Selected Publications

LaRiviere MJ, Santos PM, Hill-Kayser CE, Metz JM.: Proton Therapy. Hematology/Oncology Clinics 33(6): 989-1009, December 2019.

Baumann BC, Mitra N, Harton JG, Xiao Y, Wojcieszynski AP, Gabriel PE, Zhong H, Geng H, Doucette A, Wei J, O'Dwyer PJ, Bekelman JE, Metz JM.: Comparative Effectiveness of Proton vs Photon Therapy as Part of Concurrent Chemoradiotherapy for Locally Advanced Cancer. JAMA Oncology 6(2): 237-246, December 2019.

Kim MM, Bollinger D, Kennedy C, Zou W, Scheuermann R, Teo BK, Metz JM, Dong L, Li T.: Dosimetric Characterization of the Dual Layer MLC System for an O-Ring Linear Accelerator. Technology in Cancer Research & Treatment 18, November 2019.

Barsky AR, O'Grady F, Kennedy C, Taunk NK, Dong L, Metz JM, Li T, Freedman GM.: Initial Clinical Experience Treating Patients with Breast Cancer on a 6-MV Flattening-Filter-Free O-Ring Linear Accelerator. Advances in radiation oncology 4(4): 571-8, October 2019.

Wo JY, Plastaras JP, Metz JM, Jiang W, Yeap BY, Drapek LC, Adams J, Baglini C, Ryan DP, Murphy JE, Parikh AR, Allen JN, Clark JW, Blaszkowsky LS, DeLaney TF, Ben-Josef E, Hong TS.: Pencil Beam Scanning Proton Beam Chemoradiation Therapy With 5-Fluorouracil and Mitomycin-C for Definitive Treatment of Carcinoma of the Anal Canal: A Multi-institutional Pilot Feasibility Study. International Journal of Radiation Oncology Biology Physics 105(1): 90-5, September 2019.

Arscott WT, Gray K, Kuska D, Nagda S, Lustig R, Alonso-Basanta M, Metz JM, Jones J.: Evaluating the Impact of Secure Mobile Messaging on Communication and Cancer Care Team Satisfaction in a Large Radiation Oncology Clinic. Journal of oncology practice 15(8): 733-8, August 2019.

Kim MM, Irmen P, Shoniyozov K, Verginadis II, Cengel KA, Koumenis C, Metz JM, Dong L, Diffenderfer ES.: Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Physics in Medicine & Biology 64(13), July 2019.

Li T, Irmen P, Liu H, Shi W, Alonso-Basanta M, Zou W, Teo BK, Metz JM, Dong L.: Dosimetric Performance and Planning/Delivery Efficiency of a Dual-Layer Stacked and Staggered MLC on Treating Multiple Small Targets: A Planning Study Based on Single-Isocenter Multi-Target Stereotactic Radiosurgery (SRS) to Brain Metastases. 2019 Jan 22;9:7. doi: 10.3389/fonc.2019.00007. eCollection 2019. Front Oncol. Page: 9:7, Jan 2019.

Malajovich I, Teo BK, Petroccia H, Metz JM, Dong L, Li T.: Characterization of the Megavoltage Cone-Beam Computed Tomography (MV-CBCT) System on HalcyonTM for IGRT: Image Quality Benchmark, Clinical Performance, and Organ Doses. Frontiers in Oncology Page: 496, 2019.

Diffenderfer ES1, Verginadis II1, Kim MM1, Shoniyozov K1, Velalopoulou A1, Goia D1, Putt M1, Hagan S1, Avery S1, Teo K1, Zou W1, Lin A1, Swisher-McClure S1, Koch C1, Kennedy AR1, Minn A1, Maity A1, Busch TM1, Dong L1, Koumenis C2, Metz J1, Cengel KA3.: Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System. Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):440-448. doi: 10.1016/j.ijrobp.2019.10.049. 2019.

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Last updated: 07/15/2020
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