Charles E. Leonard, PharmD, MSCE

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Research Assistant Professor of Epidemiology in Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology

Contact information
Perelman School of Medicine at the University of Pennsylvania
807 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-573-2663
Fax: 215-573-5315
PharmD (Clinical Pharmacy)
Duquesne University, 2001.
MSCE (Clinical Epidemiology (Concentration: Pharmacoepidemiology))
University of Pennsylvania, 2011.
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Description of Clinical Expertise

clinical pharmacy

Description of Research Expertise

epidemiology, pharmacoepidemiology, comparative effectiveness research, pharmacovigilance, Medicaid, Medicare, drug-drug interactions, sudden cardiac death, ventricular arrhythmia, diabetes, hypoglycemia, ischemic stroke, propensity scores, high-dimensional propensity scores

Selected Publications

Leonard CE, Brensinger CM, Aquilante CL, Bilker WB, Boudreau DM, Deo R, Flory JH, Gagne JJ, Mangaali MJ, Hennessy S: Comparative safety of sulfonylureas and the risk of sudden cardiac arrest and ventricular arrhythmia. Diabetes Care [in press] 2018.

Leonard CE, Brensinger CM, Bilker WB, Kimmel SE, Whitaker HJ, Hennessy S: Thromboembolic and neurologic sequelae of discontinuation of an antihyperlipidemic drug during ongoing warfarin therapy. Scientific Reports [in press] 2018.

Leonard CE, Han X, Brensinger CM, Bilker WB, Cardillo S, Flory JH, Hennessy S: Comparative risk of serious hypoglycemia with oral antidiabetic monotherapy: a retrospective cohort study. Pharmacoepidemiol Drug Saf [Epub ahead of print] 2017.

Leonard CE, Hennessy S, Han X, Siscovick DS, Flory JH, Deo R: Pro- and antiarrhythmic actions of sulfonylureas: mechanistic and clinical evidence. Trends Endocrinol Metab 28(8): 561-586, Aug 2017.

Leonard CE, Brensinger CM, Nam Y, Bilker WB, Barosso GM, Mangaali MJ, Hennessy S: The quality of Medicaid and Medicare data obtained from CMS and its contractors: implications for pharmacoepidemiology. BMC Health Serv Res 17(1): 304, Apr 2017.

Leonard CE, Brensinger CM, Bilker WB, Kimmel SE, Han X, Nam Y, Gagne JJ, Mangaali MJ, Hennessy S. : Gastrointestinal bleeding and intracranial hemorrhage in concomitant users of warfarin and antihyperlipidemics. Int J Cardiol 228: 761-770, Feb 2017.

Ji X, Small DS, Leonard CE, Hennessy S: The trend-in-trend research design for causal inference. Epidemiology 28(4), Apr 2017.

Leonard CE, Han X, Bilker WB, Flory JH, Brensinger CM, Flockhart DA, Gagne JJ, Cardillo S, Hennessy S: Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics. Diabetes Res Clin Pract 115: 60-7, May 2016.

Leonard CE, Bilker WB, Brensinger CM, Han X, Flory JH, Flockhart DA, Gagne JJ, Cardillo S, Hennessy S. : Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics. Clin Pharmacol Ther 99(5): 538-47, May 2016.

Leonard CE, Bilker WB, Brensinger CM, Flockhart DA, Freeman CP, Kasner SE, Kimmel SE, Hennessy S: Comparative risk of ischemic stroke among users of clopidogrel together with individual proton pump inhibitors. Stroke 46(3): 722-731, Mar 2015.

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Last updated: 12/20/2017
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