1e
19
1
49
2
2
18
1b
1d
18
4a
9c
1d
2 29
1d
25
Charles E. Leonard, PharmD, MSCE, MPH, FISPE
78
9c
Associate Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
28
ba
3
75
Investigator, Center for Real-World Effectiveness and Safety of Therapeutics (CREST, formerly CPeRT), DBEI, PSOM (Philadelphia, PA)
9d
Faculty Member, Institute for Translational Medicine and Therapeutics (ITMAT), PSOM (Philadelphia, PA)
a6
Senior Fellow, Leonard Davis Institute of Health Economics (LDI), University of Pennsylvania (Philadelphia, PA)
80
Fellow, Institute on Aging, University of Pennsylvania (Philadelphia, PA)
64
Senior Scholar, CCEB, PSOM (Philadelphia, PA)
7e
Co-Chair, Training Program Working Group, CCEB, PSOM (Philadelphia, PA)
95
Investigator, Center of Excellence in Environmental Toxicology (CEET), PSOM (Philadelphia, PA)
11
Department: Biostatistics and Epidemiology
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
6b
4
3
3
3
2
29
6b
Perelman School of Medicine at the University of Pennsylvania
19 807 Blockley Hall
35 423 Guardian Drive
Philadelphia, PA 19104
26
19 807 Blockley Hall
35 423 Guardian Drive
Philadelphia, PA 19104
2e
Office: 215-573-2663
32 Fax: 215-573-5315
32 Lab: 215-573-2663
18
9f
12
32 Fax: 215-573-5315
32 Lab: 215-573-2663
18
Links
90 UPenn CCEB Senior Scholar Page
73 ResearchGate Profile
7f UPenn PSOM Faculty Page
88 UPenn DBEI Faculty Page
66 LinkedIn Profile
81 Google Scholar Profile
7b UPenn LDI Faculty Page
c
4
b
1f
90 UPenn CCEB Senior Scholar Page
73 ResearchGate Profile
7f UPenn PSOM Faculty Page
88 UPenn DBEI Faculty Page
66 LinkedIn Profile
81 Google Scholar Profile
7b UPenn LDI Faculty Page
c
13
Education:
21 b PharmD 1e (Clinical Pharmacy) c
2c Duquesne University, 2001.
21 9 MSCE 22 (Clinical Epidemiology) c
33 University of Pennsylvania, 2011.
21 8 MPH 1a (Public Health) c
28 Yale University, 2025.
c
3
3
3
3
8c
Permanent link21 b PharmD 1e (Clinical Pharmacy) c
2c Duquesne University, 2001.
21 9 MSCE 22 (Clinical Epidemiology) c
33 University of Pennsylvania, 2011.
21 8 MPH 1a (Public Health) c
28 Yale University, 2025.
c
2 29
21
1e
1d
24
5e
71
e 29
27
Description of Clinical Expertise
18 pharmacy71
Description of Research Expertise
1c2 epidemiology, pharmacoepidemiology, real-world evidence, comparative effectiveness, comparative safety, observational studies, cohort, case-control, self-controlled case series, case-crossover, pharmacovigilance, Medicaid, Medicare, drug interactions, sudden cardiac arrest, ventricular arrhythmia, diabetes, hypoglycemia, diabetic ketoacidosis, ischemic stroke, propensity scores, high-dimensional propensity scores, causal inferencee 29
23
11a Dhopeshwarkar N, Yang W, Hennessy S, Rhodes JM, Cuker A, Leonard CE.: Bleeding with concomitant ibrutinib and oral anticoagulant therapy: A population-based cohort study. Am J Hematol 98(3): E49-E52, Mar 2023.
155 Chen C, Hennessy S, Brensinger CM, Bilker WB, Dublin S, Chung S, Horn J, Bogar K, Leonard CE: Antidepressant drug-drug-drug interactions associated with unintentional traumatic injury: Screening for signals in real-world data. Clin Transl Sci 16(2): 326-337, Feb 2023.
18a Bogar K, Brensinger CM, Hennessy S, Flory JH, Bell ML, Shi C, Bilker WB, Leonard CE.: Climate change and ambient temperature extremes: Association with serious hypoglycemia, diabetic ketoacidosis, and sudden cardiac arrest/ventricular arrhythmia in persons with type 2 diabetes. Diabetes Care 45(11): e171-e173, Nov 2022.
195 Dawwas GK, Hennessy S, Brensinger CM, Acton EK, Bilker WB, Chung S, Dublin S, Horn JR, Manis MM, Miano TA, Oslin DW, Pham Nguyen TP, Soprano SE, Wiebe DJ, Leonard CE.: Signals of Muscle Relaxant Drug Interactions Associated with Unintentional Traumatic Injury: A Population-Based Screening Study. CNS Drugs 36(4): 389-400, Apr 2022.
d7 Medaglio D, Stephens-Shields AJ, Leonard CE.: Research and scholarly methods: Propensity scores. J Am Coll Clin Pharm 5(4): 467-475, Apr 2022.
11b Dawwas GK, Leonard CE, Lewis JD, Cuker A.: Risk for Recurrent Venous Thromboembolism and Bleeding With Apixaban Compared With Rivaroxaban: An Analysis of Real-World Data. Ann Intern Med 175(1): 20-28, Jan 2022.
149 Dawwas GK, Flory JH, Hennessy S, Leonard CE, Lewis JD.: Comparative Safety of Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis. Diabetes Care 45(4): 919-927, Apr 2022.
14c Dawwas GK, Dietrich E, Cuker A, Barnes GD, Leonard CE, Lewis JD.: Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation : A Population-Based Cohort Study. Ann Intern Med 174(4): 910-919, Jul 2021.
12b Leonard CE, Flory JH, Likić R, Ogunleye OO, Wei L, Wong I.: Spotlight commentary: A role for real-world evidence to inform the clinical care of patients with diabetes mellitus. Br J Clin Pharmacol 87(12): 4549-4551, Dec 2021.
2c
7
1d
1f
Selected Publications
151 Dhopeshwarkar N, Yang W, Hennessy S, Rhodes JM, Cuker A, Leonard CE: SuperLearner with high-dimensional propensity score to improve confounding adjustment: A real-world application in chronic lymphocytic leukemia. Pharmacoepidemiol Drug Saf 33(1): e5678, Jan 2024.11a Dhopeshwarkar N, Yang W, Hennessy S, Rhodes JM, Cuker A, Leonard CE.: Bleeding with concomitant ibrutinib and oral anticoagulant therapy: A population-based cohort study. Am J Hematol 98(3): E49-E52, Mar 2023.
155 Chen C, Hennessy S, Brensinger CM, Bilker WB, Dublin S, Chung S, Horn J, Bogar K, Leonard CE: Antidepressant drug-drug-drug interactions associated with unintentional traumatic injury: Screening for signals in real-world data. Clin Transl Sci 16(2): 326-337, Feb 2023.
18a Bogar K, Brensinger CM, Hennessy S, Flory JH, Bell ML, Shi C, Bilker WB, Leonard CE.: Climate change and ambient temperature extremes: Association with serious hypoglycemia, diabetic ketoacidosis, and sudden cardiac arrest/ventricular arrhythmia in persons with type 2 diabetes. Diabetes Care 45(11): e171-e173, Nov 2022.
195 Dawwas GK, Hennessy S, Brensinger CM, Acton EK, Bilker WB, Chung S, Dublin S, Horn JR, Manis MM, Miano TA, Oslin DW, Pham Nguyen TP, Soprano SE, Wiebe DJ, Leonard CE.: Signals of Muscle Relaxant Drug Interactions Associated with Unintentional Traumatic Injury: A Population-Based Screening Study. CNS Drugs 36(4): 389-400, Apr 2022.
d7 Medaglio D, Stephens-Shields AJ, Leonard CE.: Research and scholarly methods: Propensity scores. J Am Coll Clin Pharm 5(4): 467-475, Apr 2022.
11b Dawwas GK, Leonard CE, Lewis JD, Cuker A.: Risk for Recurrent Venous Thromboembolism and Bleeding With Apixaban Compared With Rivaroxaban: An Analysis of Real-World Data. Ann Intern Med 175(1): 20-28, Jan 2022.
149 Dawwas GK, Flory JH, Hennessy S, Leonard CE, Lewis JD.: Comparative Safety of Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis. Diabetes Care 45(4): 919-927, Apr 2022.
14c Dawwas GK, Dietrich E, Cuker A, Barnes GD, Leonard CE, Lewis JD.: Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation : A Population-Based Cohort Study. Ann Intern Med 174(4): 910-919, Jul 2021.
12b Leonard CE, Flory JH, Likić R, Ogunleye OO, Wei L, Wong I.: Spotlight commentary: A role for real-world evidence to inform the clinical care of patients with diabetes mellitus. Br J Clin Pharmacol 87(12): 4549-4551, Dec 2021.
2c