Charles E. Leonard, PharmD, MSCE, FISPE

faculty photo
Assistant Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Investigator, CPeRT, PSOM (Philadelphia, PA)
Faculty Member, Institute for Translational Medicine and Therapeutics (ITMAT), PSOM (Philadelphia, PA)
Senior Fellow, Leonard Davis Institute of Health Economics (LDI), University of Pennsylvania (Philadelphia, PA)
Core Faculty, Center for Therapeutic Effectiveness Research (CTER), PSOM (Philadelphia, PA)
Fellow, Institute on Aging, University of Pennsylvania (Philadelphia, PA)
Senior Scholar, CCEB, PSOM (Philadelphia, PA)
Co-Chair, Training Program Working Group, CCEB, PSOM (Philadelphia, PA)
Faculty Editor, Division of Epidemiology, DBEI, PSOM (Philadelphia, PA)
Department: Biostatistics and Epidemiology
Graduate Group Affiliations

Contact information
Perelman School of Medicine at the University of Pennsylvania
807 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-573-2663
Fax: 215-573-5315
Lab: 215-573-2663
Education:
PharmD (Clinical Pharmacy)
Duquesne University, 2001.
MSCE (Clinical Epidemiology (Concentration: Pharmacoepidemiology))
University of Pennsylvania, 2011.
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Description of Clinical Expertise

clinical pharmacy

Description of Research Expertise

epidemiology, pharmacoepidemiology, real-world evidence, comparative effectiveness, comparative safety, pharmacovigilance, Medicaid, Medicare, drug interactions, sudden cardiac arrest, ventricular arrhythmia, diabetes, hypoglycemia, ischemic stroke, propensity scores, high-dimensional propensity scores

Selected Publications

Dawwas GK, Hennessy S, Brensinger CM, Acton EK, Bilker WB, Chung S, Dublin S, Horn JR, Manis MM, Miano TA, Oslin DW, Pham Nguyen TP, Soprano SE, Wiebe DJ, Leonard CE.: Signals of Muscle Relaxant Drug Interactions Associated with Unintentional Traumatic Injury: A Population-Based Screening Study. CNS Drugs Mar 2022.

Medaglio D, Stephens-Shields AJ, Leonard CE.: Research and scholarly methods: Propensity scores. Journal of the American College of Clinical Pharmacy Jan 2022 Notes: https://doi.org/10.1002/jac5.1591.

Dawwas GK, Leonard CE, Lewis JD, Cuker A.: Risk for Recurrent Venous Thromboembolism and Bleeding With Apixaban Compared With Rivaroxaban: An Analysis of Real-World Data. Ann Intern Med 2022.

Dawwas GK, Flory JH, Hennessy S, Leonard CE, Lewis JD.: Comparative Safety of Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis. Diabetes Care Feb 2022.

Leonard CE, Brensinger CM, Acton EK, Miano TA, Dawwas GK, Horn JR, Chung S, Bilker WB, Dublin S, Soprano SE, Pham Nguyen TP, Manis MM, Oslin DW, Wiebe DJ, Hennessy S.: Population-Based Signals of Antidepressant Drug Interactions Associated With Unintentional Traumatic Injury. Clin Pharmacol Ther 110(2): 409-423, 2021.

Dawwas GK, Dietrich E, Cuker A, Barnes GD, Leonard CE, Lewis JD.: Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation : A Population-Based Cohort Study. Ann Intern Med 174(4): 910-919, 2021.

Pham Nguyen TP, Brensinger CM, Bilker WB, Hennessy S, Leonard CE.: Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs. Biomed Pharmacother Jul 2021.

Flory JH, Li J, Dawwas GK, Leonard CE.: Compared to commercially insured patients, Medicare advantage patients adopt newer diabetes drugs more slowly and adhere to them less. Endocrinol Diabetes Metab 4(3): e00245, Apr 2021.

Leonard CE, Flory JH, Likić R, Ogunleye OO, Wei L, Wong I.: Spotlight commentary: A role for real-world evidence to inform the clinical care of patients with diabetes mellitus. Br J Clin Pharmacol 2021.

Soprano SE, Hennessy S, Bilker WB, Leonard CE.: Assessment of Physician Prescribing of Muscle Relaxants in the United States, 2005-2016. JAMA Netw Open 3(6): e207664, Jun 2020.

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Last updated: 08/03/2022
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