In Memoriam
Helen M. Korchak
Department: Pediatrics
Contact information
1208 C Abramson Building
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: (215) 590-2136
Fax: (610) 525-1190
Fax: (610) 525-1190
Email:
KORCHAK@EMAIL.CHOP.EDU
KORCHAK@EMAIL.CHOP.EDU
Publications
Education:
Ph.D. (Physiology)
Tufts University, 1962.
Permanent linkPh.D. (Physiology)
Tufts University, 1962.
Description of Research Expertise
Research in the laboratory is elucidating the positive and negative signalling mechanisms for phagocytic cell functions such as degranulation, release of toxic oxygen species, and apoptosis. We are investigating a family of structurally related, lipid-dependent protein kinases, protein kinase C, and their role(s) in signal transduction for oxygen radical generation and degranulation. We are defining how unique structural features of particular isotypes relates to their interaction with other signalling elements and to their specific roles in cell function(s). Antisense strategies are used to selectively deplete discrete PKC isotypes in order to evaluate their roles in signal transduction.Selected Publications
Kilpatrick, L. E., Y.-H Song, M.W. Rossi and H.M. Korchak: Serine phosphorylation of p60 tumor necrosis factor receptor by protein kinase Cd in TNF-activated neutrophils. Amer. J. Physiol. 279: C2011-C2018, 2000.Yaney, G. C., H.M. Korchak and B.E. Corkey: Long chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated secretion in pancreatic b-cells (HIT). Endocrinology 141: 1989-99, 2000.
Korchak, M.M., M.W. Rossi and L.E. Kilpatrick: Selective role for b-PKC in signaling for O2 generation but not degranulation or adherence in differentiated HL cells. J. Biol. Chem. 273: 27292-299, 1998.
Deeney, J., B.A. Cunningham, S. Chheda, S., K. Bokvist, L. Juntti-Berggren, K. Lam, H.M. Korchak, B.E. Corkey and P.O. Berggren: Reversible Ca dependent translocation of protein kinase C and glucose-induced insulin release. J. Biol. Chem. 271: 18154-18160, 1996.
Kilpatrick, L.E., E. Jacabovics, L.J. McCawley, L.H. Kane and H.M. Korchak: Cromolyn inhibits assembly of the NADPH oxidase and superoxide anion generation by human neutrophils. J. Immunol 154: 3429-3436, 1995.