1e
In Memoriam
16
19
1
49
2
2
18
1b
1d
18
2e
2b
7
61
1d
2 29
1d
25
Helen M. Korchak
78
2b
7
61
Department: Pediatrics
4
1
b
1d
46
Contact information
61
4
3
3
1d
61
1208 C Abramson Building
Philadelphia, PA 19104
26
Philadelphia, PA 19104
30
Office: (215) 590-2136
34 Fax: (610) 525-1190
24
8d
34 Fax: (610) 525-1190
24
Email:
KORCHAK@EMAIL.CHOP.EDU
12
KORCHAK@EMAIL.CHOP.EDU
18
Publications
23 a
3
2
29
4
b
1f
23 a
13
Education:
21 a Ph.D. 17 (Physiology) c
29 Tufts University, 1962.
c
3
3
3
3
8b
Permanent link21 a Ph.D. 17 (Physiology) c
29 Tufts University, 1962.
c
2 29
21
1e
1d
24
5e
26 29
27
Description of Research Expertise
2ca Research in the laboratory is elucidating the positive and negative signalling mechanisms for phagocytic cell functions such as degranulation, release of toxic oxygen species, and apoptosis. We are investigating a family of structurally related, lipid-dependent protein kinases, protein kinase C, and their role(s) in signal transduction for oxygen radical generation and degranulation. We are defining how unique structural features of particular isotypes relates to their interaction with other signalling elements and to their specific roles in cell function(s). Antisense strategies are used to selectively deplete discrete PKC isotypes in order to evaluate their roles in signal transduction.26 29
23
122 Yaney, G. C., H.M. Korchak and B.E. Corkey: Long chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated secretion in pancreatic b-cells (HIT). Endocrinology 141: 1989-99, 2000.
113 Korchak, M.M., M.W. Rossi and L.E. Kilpatrick: Selective role for b-PKC in signaling for O2 generation but not degranulation or adherence in differentiated HL cells. J. Biol. Chem. 273: 27292-299, 1998.
150 Deeney, J., B.A. Cunningham, S. Chheda, S., K. Bokvist, L. Juntti-Berggren, K. Lam, H.M. Korchak, B.E. Corkey and P.O. Berggren: Reversible Ca dependent translocation of protein kinase C and glucose-induced insulin release. J. Biol. Chem. 271: 18154-18160, 1996.
11d Kilpatrick, L.E., E. Jacabovics, L.J. McCawley, L.H. Kane and H.M. Korchak: Cromolyn inhibits assembly of the NADPH oxidase and superoxide anion generation by human neutrophils. J. Immunol 154: 3429-3436, 1995.
2c
7
1d
1f
Selected Publications
11d Kilpatrick, L. E., Y.-H Song, M.W. Rossi and H.M. Korchak: Serine phosphorylation of p60 tumor necrosis factor receptor by protein kinase Cd in TNF-activated neutrophils. Amer. J. Physiol. 279: C2011-C2018, 2000.122 Yaney, G. C., H.M. Korchak and B.E. Corkey: Long chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated secretion in pancreatic b-cells (HIT). Endocrinology 141: 1989-99, 2000.
113 Korchak, M.M., M.W. Rossi and L.E. Kilpatrick: Selective role for b-PKC in signaling for O2 generation but not degranulation or adherence in differentiated HL cells. J. Biol. Chem. 273: 27292-299, 1998.
150 Deeney, J., B.A. Cunningham, S. Chheda, S., K. Bokvist, L. Juntti-Berggren, K. Lam, H.M. Korchak, B.E. Corkey and P.O. Berggren: Reversible Ca dependent translocation of protein kinase C and glucose-induced insulin release. J. Biol. Chem. 271: 18154-18160, 1996.
11d Kilpatrick, L.E., E. Jacabovics, L.J. McCawley, L.H. Kane and H.M. Korchak: Cromolyn inhibits assembly of the NADPH oxidase and superoxide anion generation by human neutrophils. J. Immunol 154: 3429-3436, 1995.
2c