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Ravinder Reddy, PhD
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Professor of Radiology
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Department: Radiology
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Graduate Group Affiliations
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Contact information
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B1 Stellar-Chance Laboratories
37 422 Curie Blvd.
Philadelphia, PA 19104-6100
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37 422 Curie Blvd.
Philadelphia, PA 19104-6100
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Office: (215) 898-5708
34 Fax: (215) 573-2113
34 Lab: (215) 898-9357
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34 Fax: (215) 573-2113
34 Lab: (215) 898-9357
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Email:
krr@pennmedicine.upenn.edu
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krr@pennmedicine.upenn.edu
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Publications
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Links
1c3 Search PubMed for articles
5a Primary Work Website
79 Ravinder Reddy weblink
76 Center for Magnetic Resonance and Optical Imaging
87 BMB graduate group faculty webpage.
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1c3 Search PubMed for articles
5a Primary Work Website
79 Ravinder Reddy weblink
76 Center for Magnetic Resonance and Optical Imaging
87 BMB graduate group faculty webpage.
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Education:
21 a B.Sc. 29 (Math, Physics, and Chemistry) c
2c Osmania University , 1979.
21 a M.Sc. 16 (Chemistry) c
2d Kakatiya University , 1982.
21 a Ph.D. 16 (Chemistry) c
3f Indian Institute of Technology, Kanpur, 1989.
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Permanent link21 a B.Sc. 29 (Math, Physics, and Chemistry) c
2c Osmania University , 1979.
21 a M.Sc. 16 (Chemistry) c
2d Kakatiya University , 1982.
21 a Ph.D. 16 (Chemistry) c
3f Indian Institute of Technology, Kanpur, 1989.
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18a Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.
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19e Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.
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Description of Research Expertise
244 My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.8
18a Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.
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19e Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.
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1cc Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C, Mohanty I, Miyake MM, Adusumalli S, Margulies KB, Prenner SB, Poole DC, Wilson N, Reddy R, Townsend RR, Ischiropoulos H, Cappola TP, Chirinos JA.: Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA Cardiol. 10((3)): 284, Mar 2025.
1db Tamaroff J, Nguyen S, Wilson NE, Stefanovski D, Xiao R, Scattergood T, Capiola C, Schur GM, Dunn J, Dedio A, Wade K, Shah H, Sharma R, Mootha VK, Kelly A, Lin KY, Lynch DR, Reddy R, Rickels MR, McCormack SE.: Insulin sensitivity and insulin secretion in adults with Friedreich's Ataxia: the role of skeletal muscle. J Clin Endocrinol Metab. 110((2)): 317, Jan 2025 Notes: doi: 10.1210/clinem/dgae545.
15c Nanga RPR, Wiers CE, Elliott MA, Wilson NE, Liu F, Cao Q, Swago S, Jacobs PS, Armbruster R, Reddy D, Baur JA, Witschey WR, Detre JA, Reddy R.: Acute nicotinamide riboside supplementation increases human cerebral NAD+ levels in vivo. Magn Reson Med. 92((6)): 2284, Dec 2024.
15f Soni ND, Swain A, Juul H, Cao Q, Haris M, Wolk DA, Lee VM, Detre JA, Nanga RPR, Reddy R.: Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI. Alzheimers Dement. 20((10)): 7124, Oct 2024.
113 Armbruster R, Wilson N, Elliott MA, Liu F, Benyard B, Jacobs P, Swain A, Nanga RPR, Reddy R. : Repeatability of Lac+ measurements in healthy human brain at 3 T. NMR Biomed. 37((9)): e5158, Sep 2024.
13d Jacobs PS, Wilson N, Brink W, Swain A, Armbruster R, Hanumapur A, Tisdall MD, Detre J, Nanga RPR, Elliott MA, Reddy R.: In vivo B+1 enhancement of calf MRI at 7 T via optimized flexible metasurfaces. Magn Reson Med. 92((3)): 1277, Sep 2024.
15e Jacobs PS, Wilson N, Brink W, Swain A, Armbruster R, Hanumapur A, Tisdall MD, Detre J, Nanga RPR, Elliott MA, Reddy R. : In vivo B 1 + enhancement of calf MRI at 7 T via optimized flexible metasurfaces. Magn Reson Med. 92((3)): 1277, Sep 2024 Notes: doi: 10.1002/mrm.30060.
16c Nanga RPR, Wiers CE, Elliott MA, Wilson NE, Liu F, Cao Q, Swago S, Jacobs PS, Armbruster R, Reddy D, Baur JA, Witschey WR, Detre JA, Reddy R. : Acute nicotinamide riboside supplementation increases human cerebral NAD+ levels in vivo. Magn Reson Med. Page: doi: 10.1002/mrm.30227. Jul 2024.
156 Armbruster RR, Kumar D, Benyard B, Jacobs P, Khandavilli A, Liu F, Nanga RPR, McCormack S, Cappola AR, Wilson N, Reddy R.: Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy. Nat Commun. 15((1)): 5387, Jun 2024.
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Selected Publications
1b8 Chakraborty K, Burman R, Nisar S, Miller S, Loschinskey Z, Wu S, Li Y, Bag AK, Khan A, Goodenough C, Wilson N, Haris M, McCormack SE, Reddy R, Ness K, Finkel R, Bagga P.: Reliability of In Vivo Creatine-Weighted Chemical Exchange Saturation Transfer (CrCEST) MRI in Calf Skeletal Muscle of Healthy Volunteers at 3 T. J Magn Reson Imaging. 61((4)): 1681, Apr 2025.1cc Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C, Mohanty I, Miyake MM, Adusumalli S, Margulies KB, Prenner SB, Poole DC, Wilson N, Reddy R, Townsend RR, Ischiropoulos H, Cappola TP, Chirinos JA.: Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. JAMA Cardiol. 10((3)): 284, Mar 2025.
1db Tamaroff J, Nguyen S, Wilson NE, Stefanovski D, Xiao R, Scattergood T, Capiola C, Schur GM, Dunn J, Dedio A, Wade K, Shah H, Sharma R, Mootha VK, Kelly A, Lin KY, Lynch DR, Reddy R, Rickels MR, McCormack SE.: Insulin sensitivity and insulin secretion in adults with Friedreich's Ataxia: the role of skeletal muscle. J Clin Endocrinol Metab. 110((2)): 317, Jan 2025 Notes: doi: 10.1210/clinem/dgae545.
15c Nanga RPR, Wiers CE, Elliott MA, Wilson NE, Liu F, Cao Q, Swago S, Jacobs PS, Armbruster R, Reddy D, Baur JA, Witschey WR, Detre JA, Reddy R.: Acute nicotinamide riboside supplementation increases human cerebral NAD+ levels in vivo. Magn Reson Med. 92((6)): 2284, Dec 2024.
15f Soni ND, Swain A, Juul H, Cao Q, Haris M, Wolk DA, Lee VM, Detre JA, Nanga RPR, Reddy R.: Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI. Alzheimers Dement. 20((10)): 7124, Oct 2024.
113 Armbruster R, Wilson N, Elliott MA, Liu F, Benyard B, Jacobs P, Swain A, Nanga RPR, Reddy R. : Repeatability of Lac+ measurements in healthy human brain at 3 T. NMR Biomed. 37((9)): e5158, Sep 2024.
13d Jacobs PS, Wilson N, Brink W, Swain A, Armbruster R, Hanumapur A, Tisdall MD, Detre J, Nanga RPR, Elliott MA, Reddy R.: In vivo B+1 enhancement of calf MRI at 7 T via optimized flexible metasurfaces. Magn Reson Med. 92((3)): 1277, Sep 2024.
15e Jacobs PS, Wilson N, Brink W, Swain A, Armbruster R, Hanumapur A, Tisdall MD, Detre J, Nanga RPR, Elliott MA, Reddy R. : In vivo B 1 + enhancement of calf MRI at 7 T via optimized flexible metasurfaces. Magn Reson Med. 92((3)): 1277, Sep 2024 Notes: doi: 10.1002/mrm.30060.
16c Nanga RPR, Wiers CE, Elliott MA, Wilson NE, Liu F, Cao Q, Swago S, Jacobs PS, Armbruster R, Reddy D, Baur JA, Witschey WR, Detre JA, Reddy R. : Acute nicotinamide riboside supplementation increases human cerebral NAD+ levels in vivo. Magn Reson Med. Page: doi: 10.1002/mrm.30227. Jul 2024.
156 Armbruster RR, Kumar D, Benyard B, Jacobs P, Khandavilli A, Liu F, Nanga RPR, McCormack S, Cappola AR, Wilson N, Reddy R.: Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy. Nat Commun. 15((1)): 5387, Jun 2024.
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