Steven E. Arnold, M.D.

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Emeritus Professor of Psychiatry
Associate Director, Institute on Aging, University of Pennsylvania, Philadelphia, PA
Associate Director, Alzheimer Disease Core Center, University of Pennsylvania
Director, Geriatric Psychiatry Section, University of Pennsylvania
Director, Penn Memory Center/Alzheimer's Disease Center Clincal Core, University of Pennsylvania, Philadelphia, PA
Department: Psychiatry

Contact information
Penn Memory Center
3615 Chestnut Street
2205 Translational Research Laboratories
123 South 31st Street
Philadelphia, PA 19104
Office: (215) 349-8225
Fax: (215) 349-8540
Lab: (215) 573-2840
M.D. (Medicine)
Boston University, 1983.
B.A. (Medical Science, Philosophy)
Boston University, Summa cum laude , 1983.
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Description of Research Expertise

schizophrenia; neuropsychiatry; cognition in aging and neurodegenerative dementias; clinicopathological correlation studies; postmortem research; cellular and molecular neuropathology; quantitative microscopy.

Description of Clinical Expertise

Evaluation, diagnosis and medical management of complex neuropsychiatric disorders; Alzheimer's disease and other neurodegenerative dementias;traumatic brain injury; cognitive, mood, and behavioral complications of neurological illness and injury.

Selected Publications

DeJesus-Cortes, H.J., Nogueras-Ortiz, C.J., Gearing, M., Arnold, S.E., Vega, I.E.: Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration. Neuroreport 23(16): 942-946, Nov 2012.

Naylor, M.D., Karlawish, J.H., Arnold, S.E., Khachaturian, A.S., Khachaturian, Z.S., Lee, V.M., Baumgart, M., Banerjee, S., Beck, C., Blennow, K., Brookmeyer, R., Brunden, K.R., Buckwalter, K.C., Comer,M., Covinsky, K., Feinberg, L.F., Frisoni, G., Green, C., Guimaraes, R.M., Gwyther, L.P., Hefti, F.F., Hutton, M., Kawas, C., Kent, D.M., Kuller, L., Langa, K.M., Mahley, R.W., Maslow, K., Masters, C.L., Meier, D.E., Neumann, P.J., Paul, S.M., Peterson, R.C., Sager, M.A., Sano, M., Schenk, D., Soares, H., Sperling, R.A., Stahl, S.M., vanDeerlin, V., Stern, Y., Weir, D., Wolk, D.A., Trojanowski, J.Q.: Advancing Alzheimer's disease diagnosis, treatment, and care: Recommendations from the Ware Invitational Summit. Alzheimers Dement 8(5): 445-52, Sep 2012.

Wolk, D.A., Zhang, Z., Boudhar, S., Clark, C.M., Pontecorvo, M.J., Arnold, S.E.: Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography. J Neurol Neurosurg Psychiatry 83(9): 923-6, Sep 2012.

Irwin, D. J., McMillan, C.T., Toledo, J.B., Arnold, S.E., Shaw, L.M., Wang, L.S., VanDeerlin, V., Lee, V.M., Trojanowski, J.Q., Grossman, M.: Comparison of cerebrospinal fluid levels of tau and ab 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms. Arch Neurol 69(8): 1018-25, Aug 2012.

Zhang, Q., Stafford, R.B., Wang, Z., Arnold, S.E., Wolk, D.A., Detre, J.A.: Microvascular Perfusion Based on Arterial Spin Labeled Perfusion MRI as a Measure of Vascular Risk in Alzheimer's Disease. J Alzheimers Dis. Aug 2012.

Hu, W.T., Holtzman, D.M., Fagan, A.M., Shaw, L.M., Perrin, R., Arnold, S.E., Grossman, M., Xiong, C., Craig-Schapiro, R., Clark, C.M., Pickering, E., Kuhn, M., Chen, Y., VanDeerlin, V.M., McClusky, L., Elman, L., Karlawish, J., Chen-Plotkin, A., Hurtig, H.I., Siderowf, A., Swenson, F., Lee, V.M., Morris, J.C., Trojanowski, J.Q., Soares, H.: Plasma multianalyte profiling in mild cognitive impairment and Alzheimer's disease. Neurology 79(9): 897-905, Aug 2012.

Toledo, J.B., Brettschneider, J., Grossman, M., Arnold, S.E., Hu, W.T., Xie, S.X., Lee, V.M., Shaw, L.M., Trojanowski, J.Q.: CSF biomarkers cutoffs: the importance of coincident neuropathological diseases. Acta Neuropathol. 124(1): 23-35, Jul 2012.

Farlow, M., Arnold, S.E., vanDyck, C.H., Aisen, P.S., Snider, B.J., Porsteinsson, A.P., Friedrich, S., Dean, R.A., Gonzales, C., Sethuraman, G., DeMattos, R.B., Mohs, R., Paul, S.M., Siemers, E.R.: Safety and biomarker effects of solanezumab in patients with Alzheimer's disease. Alzheimers Dement 8(4): 261-71, Jul 2012.

Newberg, A.B., Arnold, S.E., Wintering, N., Rovner, B.W., Alavi, A.: Initial clinical comparison of 18F-florbetapir and 18F-FDG PET in patients with Alzheimer disease and controls. J Nucl Med 53(6): 902-7, Jun 2012.

Bomfim, T.R., Forny-Germano, L., Sathler, L.B., Brito-Moreira, J., Houzel, J.C., Decker, H., Silverman, M.A., Kazi, H., Melo, H.M., McClean, P.L., Holscher, C., Arnold, S.E., Talbot, K., Klein, W.L., Munoz, D.P., Ferreira, S.T., DeFelice, F.G.: An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimeer's disease-associated Ab oligomers. J Clin Invest 122(4): 1339-53, April 2012.

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Last updated: 01/24/2013
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