Description of Research Expertise

RESEARCH INTERESTS: Biomarker studies in neurodegenerative diseases.

KEY WORDS: frontotemporal degeneration, neurolinguistics, social disorders, executive functioning, neuroimaging, cerebrospinal fluid, plasma, genetics

DESCRIPTION OF RESEARCH: We assess behavioral, imaging and biofluid measures in patients with frontotemporal degeneration spectrum disorders, including primary progressive aphasia, behavioral variant FTD, amyotrophic lateral sclerosis, corticobasal degeneration and progressive supranuclear palsy. We also study parkinson spectrum disorders. The goal is to identify the best set of behavioral, neuroimaging and biofluid measures that reflect the underlying proteinopathy in each of these patient groups. We participate in clinical treatment trials.

Description of Clinical Expertise

Young-onset neurodegenerative conditions including frontotemporal degeneration spectrum disorders such as primary progressive aphasia and behavioral variant frontotemporal degeneration, parkinson spectrum disorders such as Parkinson's disease and Lewy body disease, corticobasal degeneration and progressive supranuclear palsy, and amyotrophic lateral sclerosis.

Description of Other Expertise

Director, Penn Frontotemporal Degeneration Center