1e
19
1
49
2
2
18
1b
1d
18
33
77
1d
2 29
1d
25
Joel M Stein, MD, PhD
78
77
Associate Professor of Radiology at the Hospital of the University of Pennsylvania
28
70
3
60
Active Neuroradiologist, Penn Presbyterian Medical Center
7d
Attending Neuroradiologist, Hospital of the University of Pennsylvania
65
Active Neuroradiologist, Pennsylvania Hospital
67
Active Neuroradiologist, Chester County Hospital
8f
Faculty Member, Center for Neuroengineering and Therapeutics, University of Pennsylvania
ab
Senior Fellow, Center for Practice Transformation, Department of Radiology, University of Pennsylvania Health System
11
Department: Radiology
4
1
b
1d
46
Contact information
58
4
3
3
3
2
4
b
1f
58
Hospital of the University of Pennsylvania
1f Department of Radiology
1e 1 Silverstein Pavilion
35 3400 Spruce Street
Philadelphia, PA 19104
26
1f Department of Radiology
1e 1 Silverstein Pavilion
35 3400 Spruce Street
Philadelphia, PA 19104
35
93
Email:
joel.stein@uphs.upenn.edu
12
joel.stein@uphs.upenn.edu
13
Education:
21 7 BS 14 (Biology) c
44 University of North Carolina at Chapel Hill, 1998.
21 8 PhD 27 (Cell and Molecular Biology) c
33 University of Pennsylvania, 2005.
21 7 MD 15 (Medicine) c
33 University of Pennsylvania, 2007.
c
3
3
3
3
8b
Permanent link21 7 BS 14 (Biology) c
44 University of North Carolina at Chapel Hill, 1998.
21 8 PhD 27 (Cell and Molecular Biology) c
33 University of Pennsylvania, 2005.
21 7 MD 15 (Medicine) c
33 University of Pennsylvania, 2007.
c
2 29
21
1e
1d
24
5e
62
65
e 29
27
Description of Clinical Expertise
54 Neuroradiology, epilepsy and brain tumor imaging, functional imaging62
Description of Other Expertise
54 Mobile web and iOS applications in education and quality improvement65
Description of Research Expertise
80 Epilepsy imaging, low field MRI, molecular imaging, small animal imaging and disease models, learning and memorye 29
23
159 Arnold TC, Tu D, Okar SV, Nair G, By S, Kawatra KD, Robert-Fitzgerald TE, Desiderio LM, Schindler MK, Shinohara RT, Reich DS, Stein JM: Sensitivity of portable low-field magnetic resonance imaging for multiple sclerosis lesions. NeuroImage: Clinical 35: 103101, June 2022.
ee Arnold TC, Freeman CW, Litt B, Stein JM: Low-field MRI: Clinical promise and challenges. J Magn Reson Imaging 57(1): 25-44, Sept 2022 Notes: DOI: 10.1002/jmri.28408.
1aa Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin J-J, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs J: Functionally distinct high and low theta oscillations in the human hippocampus. Nature Communications 11(1): 2469, May 2020 Notes: doi: 10.1038/s41467-020-15670-6.
2e0 Opheim G, van der Kolk A, Markenroth Bloch K, Colon AJ, Davis KA, Henry TR, Jansen JFA, Jones SE, Pan JW, Rössler K, Stein JM, Strandberg MC, Trattnig S, Van de Moortele PF, Vargas MI, Wang I, Bartolomei F, Bernasconi N, Bernasconi A, Bernhardt B, Björkman-Burtscher I, Cosottini M, Das SR, Hertz-Pannier L, Inati S, Jurkiewicz MT, Khan AR, Liang S, Ma RE, Mukundan S, Pardoe H, Pinborg LH, Polimeni JR, Ranjeva JP, Steijvers E, Stufflebeam S, Veersema TJ, Vignaud A, Voets N, Vulliemoz S, Wiggins CJ, Xue R, Guerrini R, Guye M: 7T epilepsy task force consensus recommendations on the use of 7T MRI in clinical practice. Neurology 96(7): 327-341, February 2021.
15f Shah P, Bassett DS, Wisse LEM, Detre JA, Stein JM, Yushkevich PA, Shinohara RT, Elliott MA, Das SR, Davis KA: Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study. Human Brain Mapping 40(8): 2390-2398, June 2019.
191 Keiser MS, Ranum PT, Yrigollen CM, Carrell EM, Smith GR, Muehlmatt AL, Chen YH, Stein JM, Wolf RL, Radaelli E, Lucas TH, Gonzalez-Alegre P, and Davidson BL : Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain. Nature Medicine 27(11): 1982-1989, Nov 2021 Notes: DOI: 10.1038/s41591-021-01522-3.
1ae Salman E. Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin J-J, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs J.: Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nature Neuroscience 22(12): 2078-2086, November 2019 Notes: doi: 10.1038/s41593-019-0523-z.
1a9 Shah P, Bernabei JM, Kini L, Ashourvan A, Boccanfuso J, Archer R, Oechsel K, Das SR, Stein JM, Lucas TH, Bassett DS, Davis KA, Litt B: High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients. NeuroImage: Clinical 23: 101908, June 2019 Notes: DOI: 10.1016/j.nicl.2019.101908.
163 Amirshaghaghi A, Yan L, Miller J, Daniel Y, Stein JM, Busch TM, Cheng Z, Tsourkas A: Chlorin e6-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters as a theranostic agent for dual-mode imaging and photodynamic therapy. Scientific Reports 9(1): 2613, February 2019.
150 Shah P, Ashourvan A, Mikhail F, Pines A, Kini L, Oechsel K, Das SR, Stein JM, Shinohara RT, Bassett DS, Litt B, Davis KA: Characterizing the role of the structural connectome in seizure dynamics. Brain 142(7): 1955-1972, May 2019 Notes: doi: 10.1093/brain/awz125.
1bb Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ: Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. Nature Communications 9(1): 365, February 2018.
194 Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS.: Direct electrical stimulation of the human entorhinal region and hippocampus impairs memory. Neuron 92(5): 983-90, December 2016.
10d Schmitt JE and Stein JM: Radiographic Detection and Advanced Imaging of Glioblastoma. Glioblastoma, 1st Edition. Brem S and Abdullah KG (eds.). Elsevier, September 2016 Notes: ISBN: 9780323476607.
f0 Stein, JM (Moderator): AJNR Fellows' Journal Club Podcast. American Journal of Neuroradiology January 2015 Notes: http://www.ajnr.org/site/Podcasts/January2015FJC.mp3.
2c
7
1d
1f
Selected Publications
16a Lucas A, Arnold TC, Okar SV, Vadali C, Kawatra KD, Ren Z, Cao Q, Shinohara RT, Schindler MK, Davis KA, Litt B, Reich DS, Stein JM: Multisequence 3-T image synthesis from 64-mT low-field-strength MRI using generative adversarial networks in multiple sclerosis. Radiology 315(1), April 2025.159 Arnold TC, Tu D, Okar SV, Nair G, By S, Kawatra KD, Robert-Fitzgerald TE, Desiderio LM, Schindler MK, Shinohara RT, Reich DS, Stein JM: Sensitivity of portable low-field magnetic resonance imaging for multiple sclerosis lesions. NeuroImage: Clinical 35: 103101, June 2022.
ee Arnold TC, Freeman CW, Litt B, Stein JM: Low-field MRI: Clinical promise and challenges. J Magn Reson Imaging 57(1): 25-44, Sept 2022 Notes: DOI: 10.1002/jmri.28408.
1aa Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin J-J, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs J: Functionally distinct high and low theta oscillations in the human hippocampus. Nature Communications 11(1): 2469, May 2020 Notes: doi: 10.1038/s41467-020-15670-6.
2e0 Opheim G, van der Kolk A, Markenroth Bloch K, Colon AJ, Davis KA, Henry TR, Jansen JFA, Jones SE, Pan JW, Rössler K, Stein JM, Strandberg MC, Trattnig S, Van de Moortele PF, Vargas MI, Wang I, Bartolomei F, Bernasconi N, Bernasconi A, Bernhardt B, Björkman-Burtscher I, Cosottini M, Das SR, Hertz-Pannier L, Inati S, Jurkiewicz MT, Khan AR, Liang S, Ma RE, Mukundan S, Pardoe H, Pinborg LH, Polimeni JR, Ranjeva JP, Steijvers E, Stufflebeam S, Veersema TJ, Vignaud A, Voets N, Vulliemoz S, Wiggins CJ, Xue R, Guerrini R, Guye M: 7T epilepsy task force consensus recommendations on the use of 7T MRI in clinical practice. Neurology 96(7): 327-341, February 2021.
15f Shah P, Bassett DS, Wisse LEM, Detre JA, Stein JM, Yushkevich PA, Shinohara RT, Elliott MA, Das SR, Davis KA: Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study. Human Brain Mapping 40(8): 2390-2398, June 2019.
191 Keiser MS, Ranum PT, Yrigollen CM, Carrell EM, Smith GR, Muehlmatt AL, Chen YH, Stein JM, Wolf RL, Radaelli E, Lucas TH, Gonzalez-Alegre P, and Davidson BL : Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain. Nature Medicine 27(11): 1982-1989, Nov 2021 Notes: DOI: 10.1038/s41591-021-01522-3.
1ae Salman E. Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin J-J, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs J.: Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nature Neuroscience 22(12): 2078-2086, November 2019 Notes: doi: 10.1038/s41593-019-0523-z.
1a9 Shah P, Bernabei JM, Kini L, Ashourvan A, Boccanfuso J, Archer R, Oechsel K, Das SR, Stein JM, Lucas TH, Bassett DS, Davis KA, Litt B: High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients. NeuroImage: Clinical 23: 101908, June 2019 Notes: DOI: 10.1016/j.nicl.2019.101908.
163 Amirshaghaghi A, Yan L, Miller J, Daniel Y, Stein JM, Busch TM, Cheng Z, Tsourkas A: Chlorin e6-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters as a theranostic agent for dual-mode imaging and photodynamic therapy. Scientific Reports 9(1): 2613, February 2019.
150 Shah P, Ashourvan A, Mikhail F, Pines A, Kini L, Oechsel K, Das SR, Stein JM, Shinohara RT, Bassett DS, Litt B, Davis KA: Characterizing the role of the structural connectome in seizure dynamics. Brain 142(7): 1955-1972, May 2019 Notes: doi: 10.1093/brain/awz125.
1bb Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ: Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. Nature Communications 9(1): 365, February 2018.
194 Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS.: Direct electrical stimulation of the human entorhinal region and hippocampus impairs memory. Neuron 92(5): 983-90, December 2016.
10d Schmitt JE and Stein JM: Radiographic Detection and Advanced Imaging of Glioblastoma. Glioblastoma, 1st Edition. Brem S and Abdullah KG (eds.). Elsevier, September 2016 Notes: ISBN: 9780323476607.
f0 Stein, JM (Moderator): AJNR Fellows' Journal Club Podcast. American Journal of Neuroradiology January 2015 Notes: http://www.ajnr.org/site/Podcasts/January2015FJC.mp3.
2c