Shampa Chatterjee, Ph.D.

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Research Associate Professor of Physiology
Department: Physiology

Contact information
Institute for Environmental Medicine,
1 John Morgan
Philadelphia, PA 19104
Office: 215 898 9101 (Office)
Fax: 215 898 0868
Lab: 215 898 9093 (Lab)
Education:
PhD (Chemistry)
Indian Institute of Technology, Bombay, India, 1997.
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Description of Research Expertise

Endothelial cells that line blood vessels. are continuously exposed to mechanical forces from blood flow and chemical stimuli from our environment. Irrespective of whether these are externally applied or arising from physiological “events”, these stimuli trigger changes in intracellular biochemical signaling and gene expression, eventually leading to cell differentiation, migration and apoptosis.

A major focus of my research is toward understanding endothelial responses that initiate and amplify inflammation. To achieve this, we employ in vitro, in situ an din vivo models of inflammation. Inflammation is simulated in my lab by 1) an in vitro flow adapted pulmonary endothelial cell network model 2) an in vivo mouse model of intratracheal endotoxin instillation 3) an in situ mouse lung ischemia reperfusion model and 4) clinical studies on e-cig smokers. For periodontal inflammation studies, we have developed an endotoxin exposed 3 D in vitro gum model. Our overall plan is employ these models to interrogate the role of inflammation signaling pathways in injury, so as to enable the design of interventional strategies to mitigate tissue damage.

Selected Publications

Elizabeth Browning, Hui Wang, Nankang Hong, Kevin Yu, Donald G. Buerk, Kristine DeBolt, Daniel Gonder, Elena M. Sorokina, Puja Patel, Diva D. De Leon, Sheldon I. Feinstein, Aron B. Fisher and Shampa Chatterjee : Mechanotransduction drives post ischemic revascularization through KATP channel closure and production of reactive oxygen species. Antioxidants and Redox Signaling 20(6): 872-886, February 2014.

Rebecca L. Orndorff, Nankang Hong, Kevin Yu, Sheldon I. Feinstein, Blaine J. Zern, Aron B. Fisher, Vladimir R. Muzykantov, Shampa Chatterjee: NOX2 in lung inflammation: Quantum dot based in situ imaging of NOX2 mediated expression of vascular cell adhesion molecule-1 (VCAM) American Journal of Physiol. Lung Cell and Mol Physiol. 306: L260-268, January 2014.

John Noel, Hui Wang, Nankang Hong, Jian-Qin Tao, Kevin Yu, Elena M. Sorokina, Kristine DeBolt, Michelle Heayn, Victor Rizzo, Horace Delisser, Aron B. Fisher and Shampa Chatterjee: PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium Am J Physiology : Lung Cell Mol Physiol 305: L805-818, October 2013.

Noel, J and S. Chatterjee : Shear Stress and Vascular Inflammation; A study in the Lung. In Inflammation, Molecular Pathophysiology, Nutritional and Therapeutic Interventions. Eds, Roy, S, Sen C. K. and Roychowdhury, S. (eds.). Taylor and Francis, Florence, KY, Page: 229, 2012.

Lee I, Dodia C, Chatterjee S, Feinstein SI, Fisher AB. : Protection against LPS-induced acute lung injury by a mechanism based inhibitor of NADPH-oxidase (Type 2). Am J Physiol Lung Cell Mol Physiol. 306(7): L635-644, April 2014.

Shampa Chatterjee and Aron Fisher: Mechanotransduction: Forces, Sensors and Redox Signaling. Antioxidants and Redox Signaling 20(6): 868-871, February 2014.

Shampa Chatterjee and Aron Fisher: Mechanotransduction in the Endothelium: Role of membrane proteins and reactive oxygen species in sensing, transduction and transmission of the signal with altered blood flow Antioxidants and Redox Signaling 20(6): 899-913, February 2014.

Lee I, Dodia C, Chatterjee S, Zagorski J, Mesaros C, Blair IA, Feinstein SI, Jain M, Fisher AB.: A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung. J Pharmacol Exp Ther. 345(2): 284-296, March 2013.

Chatterjee, S, Browning, E.A., Hong, N., DeBolt, K., Sorokina, E., Liu, W. and Aron B. Fisher: Membrane depolarization is the trigger for PI3Kinase/Akt activation and leads to the generation of reactive oxygen species. American Journal of Physiology: Heart and Circ Physiology 302(1): H105-14, January 2012.

Chatterjee S, Feinstein SI, Dodia C, Sorokina E, Lien YC, Nguyen S, Debolt K, Speicher D, Fisher AB. : Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages. J Biol Chem. Am Society for Biochemistry and Molecular Biology, 286: 11696-706, 2011.

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Last updated: 04/04/2020
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