Susan M Domchek, MD, FASCO
Basser Professor in Oncology
Director, Cancer Risk Evaluation Program, Abramson Cancer Center, University of Pennsylvania
Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania
Executive Director, Basser Center for BRCA
Department: Medicine
Contact information
Division of Hematology Oncology
10th Floor, South Pavilion
Office #10-157
3400 Civic Center Boulevard
Philadelphia, PA 19104
10th Floor, South Pavilion
Office #10-157
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-7096
Fax: 215-349-5314
Fax: 215-349-5314
Education:
BA (Engineering Sciences)
Dartmouth College, 1990.
MD (Internal Medicine)
Harvard Medical School, 1995.
Permanent linkBA (Engineering Sciences)
Dartmouth College, 1990.
MD (Internal Medicine)
Harvard Medical School, 1995.
Description of Research Expertise
Breast cancer geneticsBreast cancer prevention and screening
Breast cancer immunotherapy clinical trials
Description of Clinical Expertise
Breast cancer prevention, screening and treatmentBreast cancer genetics
Selected Publications
Yadav S, Couch FJ, Domchek SM.: Germline Genetic Testing for Hereditary Breast and Ovarian Cancer: Current Concepts in Risk Evaluation. Cold Spring Harb Perspect Med. 14(8), August 2024.Lau-Min KS, Symecko H, Spielman K, Mann D, Hood R, Rathore S, Wolfe C, Gabriel PE, Rendle KA, Nathanson KL, Reiss KA, Domchek SM.: Integration of Germline Genetic Testing Into Routine Clinical Practice for Patients With Pancreatic Adenocarcinoma JCO Oncol Pract. July 2024 Notes: doi: 10.1200/OP.24.00356.Epub ahead of print
Cheng HH, Shevach JW, Castro E, Couch FJ, Domchek SM, Eeles RA, Giri VN, Hall MJ, King MC, Lin DW, Loeb S, Morgan TM, Offit K, Pritchard CC, Schaeffer EM, Szymaniak BM, Vassy JL, Katona BW, Maxwell KN.: BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review. JAMA Oncol July 2024 Notes: doi: 10.1001/jamaoncol.2024.2185.Epub ahead of print
Niccum BA, Coughlin S, Clay D, Heiman J, Buckley KH, Dungan M, Daniel MG, Ruiz J, Maxwell KN, Domchek SM, Leung G, Ahmad NA, Ginsberg GG, Kochman ML, Katona BW.: Prevalence of H. pylori and Gastric Intestinal Metaplasia in BRCA1 and BRCA2 Carriers. Cancer Prev Res (Phila) 17(7): 305-309, July 2024.
Rowlands CF, Allen S, Balmaña J, Domchek SM, Evans DG, Hanson H, Hoogerbrugge N,James PA, Nathanson KL, Robson M, Tischkowitz M, Foulkes WD, Turnbull C.: Population-based germline breast cancer gene association studies and meta-analysis to inform wider mainstream testing. Ann Oncol. July 2024 Notes: doi: 10.1016/j.annonc.2024.07.244. Epub ahead of print
Maxwell KN, Domchek SM. : Toward Application of Polygenic Risk Scores to Both Enhance and Deintensify Breast Cancer Screening. J Clin Oncol. 42(13): 1462-1465, May 2024.
Ward A, Farengo-Clark D, McKenna DB, Safonov A, Good M, Le A, Kessler L, Shah PD, Bradbury AR, Domchek SM, Nathanson KL, Powers J, Maxwell KN. : Clinical Management of TP53 Mosaic Variants Found on Germline Genetic Testing. Cancer Genet. April 2024 Notes: doi: 10.1016/j.cancergen.2024.04.002. Epub ahead of print.
Domchek SM, Vonderheide RH. : Advancing Cancer Interception. Cancer Discov. 14(4): 600-604, April 2024 Notes: doi: 10.1158/2159-8290.CD-24-0015. P
Ganz PA, Bandos H, Španić T, Friedman S, Müller V, Kuemmel S, Delaloge S, Brain E, Toi M, Yamauchi H, de Dueñas EM, Armstrong A, Im SA, Song CG, Zheng H, Sarosiek T, Sharma P, Geng C, Fu P, Rhiem K, Frauchiger-Heuer H, Wimberger P, t'Kint de Roodenbeke D, Liao N, Goodwin A, Chakiba-Brugère C, Friedlander M, Lee KS, Giacchetti S, Takano T, Henao-Carrasco F, Virani S, Valdes-Albini F, Domchek SM, Bane C, McCarron EC, Mita M, Rossi G, Rastogi P, Fielding A, Gelber RD, Scheepers ED, Cameron D,Garber J, Geyer CE, Tutt ANJ. : Patient-Reported Outcomes in OlympiA: A Phase III, Randomized, Placebo- Controlled Trial of Adjuvant Olaparib in gBRCA1/2 Mutations and High-Risk Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer. J Clin Oncol. 42(11): 1288-1300, April 2024.
Niccum BA, Coughlin S, Clay D, Heiman J, Buckley KH, Dungan M, Daniel MG, Ruiz J, Maxwell KN, Domchek SM, Leung G, Ahmad NA, Ginsberg GG, Kochman ML, Katona BW. : Prevalence of H. Pylori and Gastric Intestinal Metaplasia in BRCA1 and BRCA2 Carriers Cancer Prev Res (Phila) April 2024 Notes: doi:10.1158/1940-6207.CAPR-24-0039. Epub ahead of print.