Jeffrey Brian Doyon, MD, PhD
Philadelphia, PA 19104
BA (Chemistry and Minor in Physics)
Swarthmore College, 2000.
MS (Chemistry and Chemical Biology)
Harvard University, 2004.
PhD (Chemistry and Chemical Biology)
Harvard University, 2006.
University of California, San Francisco, 2014.
Description of Clinical ExpertiseInfectious diseases in immunocompromised patients
Selected PublicationsDoyon JB, Zeitler B, Cheng J, Cheng AT, Cherone JM, Santiago Y, Lee AH, Vo TD, Doyon Y, Miller JC, Paschon DE, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Drubin DG: Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells. Nat Cell Biol 13(3): 331-7, Mar 2011.
Doyon JB, Liu DR: Identification of eukaryotic promoter regulatory elements using nonhomologous random recombination. Nucleic Acids Res 35(17): 5851-60, Aug 2007.
Doyon JB, Pattanayak V, Meyer CB, Liu DR: Directed evolution and substrate specificity profile of homing endonuclease I-SceI. J Am Chem Soc 128(7): 2477-84, Feb 2006.
Gartner ZJ, Tse BN, Grubina R, Doyon JB, Snyder TM, Liu DR: DNA-templated organic synthesis and selection of a library of macrocycles. Science 305(5690): 1601-5, Sep 2004.
Doyon JB, Snyder TM, Liu DR: Highly sensitive in vitro selections for DNA-linked synthetic small molecules with protein binding affinity and specificity. J Am Chem Soc 125(41): 12372-3, Oct 2003.
Madder RD, Kim C-Y, Chandra PP, Doyon JB, Baird TA, Fierke CA, Christianson DW, Voet JG, Jain A: Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase. J Org Chem 67(2): 582-4, Jan 2002.
Mattoon D, Gupta K, Doyon J, Loll PJ, DiMaio D: Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein. Oncogene 20(29): 3824-34, Jun 2001.
Kim CY, Chang JS, Doyon JB, Baird TT, Fierke CA, Jain A, Christianson DW: Contribution of Fluorine to Protein−Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II. J Am Chem Soc 122(49): 12125-12134, Nov 2000.
Doyon JB, Hansen EA, Kim CY, Chang JS, Christianson DW, Madder RD, Voet JG, Baird TA, Fierke CA, Jain A: Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II. Org Lett 2(16): 2557-8, Aug 10 2000.
Doyon JB, Hansen EA, Kim CY, Chang JS, Christianson DW, Madder RD, Voet JG, Baird TA, Fierke CA, Jain A: Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II. Org Lett 2(9): 1189-92, May 4 2000.