In Memoriam
Richard S. Spielman, Ph.D.
Department: Genetics
Contact information
464 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
415 Curie Boulevard
Philadelphia, PA 19104-6145
Office: 215-898-5763
Fax: 215-573-9598
Fax: 215-573-9598
Email:
SPIELMAN@MAIL.MED.UPENN.EDU
SPIELMAN@MAIL.MED.UPENN.EDU
Publications
Education:
A.B. (Biology (cum laude))
Harvard College, 1967.
M.S. (Human Genetics)
University of Michigan, 1968.
Ph.D. (Human Genetics)
University of Michigan, 1971.
Permanent linkA.B. (Biology (cum laude))
Harvard College, 1967.
M.S. (Human Genetics)
University of Michigan, 1968.
Ph.D. (Human Genetics)
University of Michigan, 1971.
Description of Research Expertise
Biometrical genetics, linkage analysisGenetics of "Complex" Diseases
Genetics of variation in gene expression
Selected Publications
Spielman RS., McGinnis RE., Ewens WJ.: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics 52(3): 506-16, Mar 1993.Cheung, V. G., Conlin, L. K., Weber, T. M., Arcaro, M., Jen, K. Y., Morley, M., Spielman, R. S.: Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet 33(3): 422-5, 2003.
Morley, M., Molony, C. M., Weber, T. M., Devlin, J. L., Ewens, K. G., Spielman, R. S., Cheung, V. G.: Genetic analysis of genome-wide variation in human gene expression. Nature 430(7001): 743-7, 2004.
Cheung, V. G., Spielman, R. S., Ewens, K. G., Weber, T. M., Morley, M., Burdick, J. T.: Mapping determinants of human gene expression by regional and genome-wide association. Nature 437(7063): 1365-9, 2005.
Stewart, D. R., Dombroski, B., Urbanek, M., Ankener, W., Ewens, K. G., Wood, J. R., Legro, R. S., Strauss, J. F., 3rd, Dunaif, A., Spielman, R. S.: Fine Mapping of Genetic Susceptibility to Polycystic Ovary Syndrome on Chromosome 19p13.2 and Tests for Regulatory Activity. J Clin Endocrinol Metab 2006.
Spielman, R. S., Bastone, L. A., Burdick, J. T., Morley, M., Ewens, W. J., Cheung, V. G.: Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet 39(2): 226-31, 2007.
Cheung, V. G., Bruzel, A., Burdick, J. T., Morley, M., Devlin, J.L., Spielman, R.S.: Monozygotic twins reveal germline contribution to allelic expression differences. Am J Hum Genet 82: 1-4, 2008.
Price, A. L., Patterson, N., Hancks, D. C., Myers, S., Reich, D., Cheung, V. G., Spielman, R. S.: Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans. PLoS Genet 4(12): e1000294. doi:10.1371/journal.pgen.1000294, 2008.
Smirnov, D.A., Morley, M., Shin, E., Spielman, R., Cheung, V. G.: Genetic analysis of radiation-induced changes in human gene expression. Nature 2009.