Richard S. Spielman, Ph.D.

faculty photo
Department: Genetics

Contact information
464 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
Office: 215-898-5763
Fax: 215-573-9598
A.B. (Biology (cum laude))
Harvard College, 1967.
M.S. (Human Genetics)
University of Michigan, 1968.
Ph.D. (Human Genetics)
University of Michigan, 1971.
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Description of Research Expertise

Biometrical genetics, linkage analysis
Genetics of "Complex" Diseases
Genetics of variation in gene expression

Selected Publications

Spielman RS., McGinnis RE., Ewens WJ.: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). American Journal of Human Genetics 52(3): 506-16, Mar 1993.

Cheung, V. G., Conlin, L. K., Weber, T. M., Arcaro, M., Jen, K. Y., Morley, M., Spielman, R. S.: Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet 33(3): 422-5, 2003.

Morley, M., Molony, C. M., Weber, T. M., Devlin, J. L., Ewens, K. G., Spielman, R. S., Cheung, V. G.: Genetic analysis of genome-wide variation in human gene expression. Nature 430(7001): 743-7, 2004.

Cheung, V. G., Spielman, R. S., Ewens, K. G., Weber, T. M., Morley, M., Burdick, J. T.: Mapping determinants of human gene expression by regional and genome-wide association. Nature 437(7063): 1365-9, 2005.

Stewart, D. R., Dombroski, B., Urbanek, M., Ankener, W., Ewens, K. G., Wood, J. R., Legro, R. S., Strauss, J. F., 3rd, Dunaif, A., Spielman, R. S.: Fine Mapping of Genetic Susceptibility to Polycystic Ovary Syndrome on Chromosome 19p13.2 and Tests for Regulatory Activity. J Clin Endocrinol Metab 2006.

Spielman, R. S., Bastone, L. A., Burdick, J. T., Morley, M., Ewens, W. J., Cheung, V. G.: Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet 39(2): 226-31, 2007.

Cheung, V. G., Bruzel, A., Burdick, J. T., Morley, M., Devlin, J.L., Spielman, R.S.: Monozygotic twins reveal germline contribution to allelic expression differences. Am J Hum Genet 82: 1-4, 2008.

Price, A. L., Patterson, N., Hancks, D. C., Myers, S., Reich, D., Cheung, V. G., Spielman, R. S.: Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans. PLoS Genet 4(12): e1000294. doi:10.1371/journal.pgen.1000294, 2008.

Smirnov, D.A., Morley, M., Shin, E., Spielman, R., Cheung, V. G.: Genetic analysis of radiation-induced changes in human gene expression. Nature 2009.

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Last updated: 03/08/2007
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