Pablo Tebas, M.D.

faculty photo
Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Academic Address: 502 Johnson Pavilion
Clinical Office: 4 Perelman Center for Advanced Medicine, 3600 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-349-8092
Fax: 215-349-8011
Education:
MD
Universidad Autónoma de Madrid, Spain, 1985.
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Description of Research Expertise

My research interests center around the study of the complications of HIV and its treatment, and currently in the evaluation of strategies for the cure of HIV infection.
I am the director and the PI of the AIDS clinical trial unit of the University of Pennsylvania.
I am one of the founding members of the HIV Reservoirs and Viral Eradication (Cure) Transformative Science Group (TSG) of the AIDS clinical trial group. In addition to my ACTG work, I am involved (as PI of the clinical project) in several early phase trials of new compounds developed in conjunction with the NIH in several IPCP grants, including a Phase I study evaluating the antiviral activity of aprepitant (an NK-1R antagonist that down-regulates the expression of CCR5), a phase I study evaluating the immunogenicity of a therapeutic DNA vaccine administered by intramuscular electroporation in collaboration with David Weiner and several gene therapy studies evaluating the therapeutic use of lentiviral vectors in the management of HIV infection (including the use of VIRxSYS 496 –antisense approach-, the first in humans Sangamo’s zinc finger nuclease for CCR5 edition, in collaboration with Dr. Carl June.

Description of Clinical Expertise

My clinical interest focus on the treatment of HIV infection and associated infections like hepatitis C. I have also a particular interest in the clinical manifestations and treatment of atypical mycobacterial infections. I also attend every year in the general infectious disease service of the hospital of University of Pennsylvania

Selected Publications

Bertagnolli, L. N., White, J. A., Simonetti, F. R., Beg, S. A., Lai, J., Tomescu, C., Murray, A. J., Antar, A. A. R., Zhang, H., Margolick, J. B., Hoh, R., Deeks, S. G., Tebas, P., Montaner, L. J., Siliciano, R. F., Laird, G. M., Siliciano, J. D.: The role of CD32 during HIV-1 infection. Nature 561(7723): E17-E19, Sep 2018.

Namazi, G., Fajnzylber, J. M., Aga, E., Bosch, R., Acosta, E. P., Sharaf, R., Hartogensis, W., Jacobson, J. M., Connick, E., Volberding, P., Skiest, D., Margolis, D., Sneller, M. C., Little, S. J., Gianella, S., Smith, D., Kuritzkes, D. R., Gulick, R. M., Mellors, J. W., Mehraj, V., Gandhi, R. T., Mitsuyasu, R., Schooley, R. T., Henry, K., Tebas, P., Deeks, S., Chun, T. W., Collier, A. C., Routy, J. P., Hecht, F. M., Walker, B. D., Li, J. Z.: The Control of HIV after Antiretroviral Medication Pause (CHAMP) study: post-treatment controllers identified from 14 clinical studies. J Infect Dis Page: doi: 10.1093/infdis/jiy479, Aug 2018.

Salantes, D. B., Zheng, Y., Mampe, F., Srivastava, T., Beg, S., Lai, J., Li, J. Z., Tressler, R. L., Koup, R. A., Hoxie, J., Abdel-Mohsen, M., Sherrill-Mix, S., McCormick, K., Overton, E. T., Bushman, F. D., Learn, G. H., Siliciano, R. F., Siliciano, J. M., Tebas, P., Bar, K. J.: HIV-1 latent reservoir size and diversity are stable following brief treatment interruption. J Clin Invest 128(7): 3102-3115, Jul 2018.

LaFleur, J., Bress, A. P., Myers, J., Rosenblatt, L., Crook, J., Knippenberg, K., Bedimo, R., Tebas, P., Nyman, H., Esker, S.: Tenofovir-Associated Bone Adverse Outcomes among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals. Infect Dis Ther 7(2): 293-308, Jun 2018.

Bedimo, R. J., Adams-Huet, B., Poindexter, J., Brown, G., Farukhi, I., Castanon, R., Turner, D., Moore, T., Tebas, P., Maalouf, N. M.: The Differential Effects of Human Immunodeficiency Virus and Hepatitis C Virus on Bone Microarchitecture and Fracture Risk. Clin Infect Dis 66(9): 1442-1447, Apr 2018.

Abdel-Mohsen, M., Kuri-Cervantes, L., Grau-Exposito, J., Spivak, A. M., Nell, R. A., Tomescu, C., Vadrevu, S. K., Giron, L. B., Serra-Peinado, C., Genesca, M., Castellvi, J., Wu, G., Del Rio Estrada, P. M., Gonzalez-Navarro, M., Lynn, K., King, C. T., Vemula, S., Cox, K., Wan, Y., Li, Q., Mounzer, K., Kostman, J., Frank, I., Paiardini, M., Hazuda, D., Reyes-Teran, G., Richman, D., Howell, B., Tebas, P., Martinez-Picado, J., Planelles, V., Buzon, M. J., Betts, M. R., Montaner, L. J.: CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells. Sci Transl Med 10(437), Apr 2018.

Benson, C. A., Andersen, J. W., Macatangay, B. J. C., Mailliard, R. B., Rinaldo, C. R., Jr., Read, S., Bozzolo, D. R., Purdue, L., Jennings, C., Keefer, M. C., Glesby, M., Tebas, P., Russell, A. F., Martin, J., Annunziato, P., Popmihajlov, Z., Lennox, J. L.: Safety and Immunogenicity of Zoster Vaccine Live in HIV-Infected Adults with CD4+ Cell Counts Above 200 Cells/mL Virologically Suppressed on Antiretroviral Therapy. Clin Infect Dis. Page: 10.1093/cid/ciy242, Mar 2018.

Kudchodkar, S. B., Choi, H., Reuschel, E. L., Esquivel, R., Jin-Ah Kwon, J., Jeong, M., Maslow, J. N., Reed, C. C., White, S., Kim, J. J., Kobinger, G. P., Tebas, P., Weiner, D. B., Muthumani, K.: Rapid response to an emerging infectious disease - Lessons learned from development of a synthetic DNA vaccine targeting Zika virus. Microbes Infect Mar 2018.

LaFleur, J., Bress, A. P., Esker, S., Knippenberg, K., Crook, J., Nyman, H., Bedimo, R., Tebas, P., Rosenblatt, L.: Brief Report: Tenofovir-Associated Nephrotoxicity Among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals. J Acquir Immune Defic Syndr 77(3): 325-330, Mar 2018.

Bedimo, R. J., Adams-Huet, B., Poindexter, J., Brown, G., Farukhi, I., Castanon, R., Turner, D., Moore, T., Tebas, P., Maalouf, N. M.: The Differential Effects of HIV and HCV on Bone Micro-Architecture and Fracture risk. Clin Infect Dis November 2017.

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Last updated: 10/25/2018
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