Pablo Tebas, MD

faculty photo
Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Academic Address: 502 Johnson Pavilion
Clinical Office: 4 Perelman Center for Advanced Medicine, 3600 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-349-8092
Fax: 215-349-8011
Education:
MD
Universidad Autónoma de Madrid, Spain, 1985.
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Description of Research Expertise

My research interests center around the study of the complications of HIV and its treatment, and currently in the evaluation of strategies for the cure of HIV infection.
I am the director and the PI of the AIDS clinical trial unit of the University of Pennsylvania.
I am one of the founding members of the HIV Reservoirs and Viral Eradication (Cure) Transformative Science Group (TSG) of the AIDS clinical trial group. In addition to my ACTG work, I am involved (as PI of the clinical project) in several early phase trials of new compounds developed in conjunction with the NIH in several IPCP grants, including a Phase I study evaluating the antiviral activity of aprepitant (an NK-1R antagonist that down-regulates the expression of CCR5), a phase I study evaluating the immunogenicity of a therapeutic DNA vaccine administered by intramuscular electroporation in collaboration with David Weiner and several gene therapy studies evaluating the therapeutic use of lentiviral vectors in the management of HIV infection (including the use of VIRxSYS 496 –antisense approach-, the first in humans Sangamo’s zinc finger nuclease for CCR5 edition, in collaboration with Dr. Carl June.

Description of Clinical Expertise

My clinical interest focus on the treatment of HIV infection and associated infections like hepatitis C. I have also a particular interest in the clinical manifestations and treatment of atypical mycobacterial infections. I also attend every year in the general infectious disease service of the hospital of University of Pennsylvania

Selected Publications

Papasavvas, E., Azzoni, L., Pagliuzza, A., Abdel-Mohsen, M., Ross, B. N., Fair, M., Howell, B., Hazuda, D., Chomont, N., Li, Q., Mounzer, K., Kostman, J. R., Tebas, P., Montaner, L. J.: Safety, immune and anti-viral effects of pegylated interferon alpha 2b administration in ART-suppressed individuals: Results of pilot clinical trial. AIDS Res Hum Retroviruses December 2020.

Bertagnolli, L. N., Varriale, J., Sweet, S., Brockhurst, J., Simonetti, F. R., White, J., Beg, S., Lynn, K., Mounzer, K., Frank, I., Tebas, P., Bar, K. J., Montaner, L. J., Siliciano, R. F., Siliciano, J. D.: Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1. Proc Natl Acad Sci U S A 117(50): 32066-32077, December 2020.

Gu, C. H., Zhao, C., Hofstaedter, C., Tebas, P., Glaser, L., Baldassano, R., Bittinger, K., Mattei, L. M., Bushman, F. D.: Investigating hospital Mycobacterium chelonae infection using whole genome sequencing and hybrid assembly. PLoS One 15(11): e0236533, November 2020.

Walker, S. N., Chokkalingam, N., Reuschel, E. L., Purwar, M., Xu, Z., Gary, E. N., Kim, K. Y., Helble, M., Schultheis, K., Walters, J., Ramos, S., Muthumani, K., Smith, T. R. F., Broderick, K. E., Tebas, P., Patel, A., Weiner, D. B., Kulp, D. W.: SARS-CoV-2 Assays To Detect Functional Antibody Responses That Block ACE2 Recognition in Vaccinated Animals and Infected Patients. J Clin Microbiol 58(11), October 2020.

Choi, H., Kudchodkar, S. B., Ho, M., Reuschel, E. L., Reynolds, E., Xu, Z., Bordoloi, D., Ugen, K. E., Tebas, P., Kim, J., Abdel-Mohsen, M., Thangamani, S., Weiner, D. B., Muthumani, K.: A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus. PLoS Negl Trop Dis 14(10): e0008788, October 2020.

Pau, A. K., Aberg, J., Baker, J., Belperio, P. S., Coopersmith, C., Crew, P., Glidden, D. V., Grund, B., Gulick, R. M., Harrison, C., Kim, A., Lane, H. C., Masur, H., Sheikh, V., Singh, K., Yazdany, J., Tebas, P.: Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel. Ann Intern Med September 2020.

Abdel-Mohsen, M., Richman, D., Siliciano, R. F., Nussenzweig, M. C., Howell, B. J., Martinez-Picado, J., Chomont, N., Bar, K. J., Yu, X. G., Lichterfeld, M., Alcami, J., Hazuda, D., Bushman, F., Siliciano, J. D., Betts, M. R., Spivak, A. M., Planelles, V., Hahn, B. H., Smith, D. M., Ho, Y. C., Buzon, M. J., Gaebler, C., Paiardini, M., Li, Q., Estes, J. D., Hope, T. J., Kostman, J., Mounzer, K., Caskey, M., Fox, L., Frank, I., Riley, J. L., Tebas, P., Montaner, L. J., Beat-Hiv Delaney Collaboratory to Cure HIV-1 infection: Recommendations for measuring HIV reservoir size in cure-directed clinical trials. Nat Med 26(9): 1339-1350, September 2020.

Giron, L. B., Colomb, F., Papasavvas, E., Azzoni, L., Yin, X., Fair, M., Anzurez, A., Damra, M., Mounzer, K., Kostman, J. R., Tebas, P., O'Doherty, U., Tateno, H., Liu, Q., Betts, M. R., Montaner, L. J., Abdel-Mohsen, M.: Interferon-alpha alters host glycosylation machinery during treated HIV infection. EBioMedicine 59: 102945, September 2020.

Papasavvas, E., Azzoni, L., Ross, B. N., Fair, M., Yuan, Z., Gyampoh, K., Mackiewicz, A., Sciorillo, A. C., Paggliuzza, A., Lada, S. M., Wu, G., Goh, S. L., Bahnck-Teets, C., Holder, D. J., Zuck, P. D., Damra, M., Lynn, K. M., Tebas, P., Mounzer, K., Kostman, J. R., Abdel-Mohsen, M., Richman, D., Chomont, N., Howell, B. J., Montaner, L. J.: Intact HIV reservoir estimated by the intact proviral DNA assay correlates with levels of total and integrated DNA in the blood during suppressive antiretroviral therapy. Clin Infect Dis June 2020.

Azzoni, L., Ross, B., Fair, M., Pagliuzza, A., Lada, S., Wu, G., Zuck, P., Tebas, P., Mounzer, K., Kostman, J. R., Abdel –Mohsen, M., Richman, D., Chomont, N., Howell, B.J., Montaner, L. J.: Distinct HIV reservoir measures correlate with defective but not intact proviral DNA. 27th Conference on Retrovirus and Opportunistic infections. March 8-11 2020 Boston, Abstract #309 March 2020.

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Last updated: 12/26/2020
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