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Charles C. Clark, Ph.D.
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Emeritus Associate Professor of Orthopaedic Surgery
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Department: Orthopaedic Surgery
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Contact information
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McKay Orthopaedic Research Laboratory
1a 376A Stemmler Hall
3a 3450 Hamilton Walk
Philadelphia, PA 19104-6081
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1a 376A Stemmler Hall
3a 3450 Hamilton Walk
Philadelphia, PA 19104-6081
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Office: 215-898-8653
32 Fax: 215-573-2133
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32 Fax: 215-573-2133
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Education:
21 9 B.A. 16 (Chemistry) c
34 Gannon University, Erie, PA, 1965.
21 a Ph.D. 19 (Biochemistry) c
3d Northwestern University, Chicago, IL, 1970.
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Permanent link21 9 B.A. 16 (Chemistry) c
34 Gannon University, Erie, PA, 1965.
21 a Ph.D. 19 (Biochemistry) c
3d Northwestern University, Chicago, IL, 1970.
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110 Myers JC., Li D., Rubinstein NA., Clark CC.: Up-regulation of type XIX collagen in rhabdomyosarcoma cells accompanies myogenic differentiation. Experimental Cell Research 253(2): 587-98, Dec 15 1999.
d9 Jones AR., Brighton CT., Clark CC.: Collagen production by microvascular pericytes in long term culture. Trans. Orthop. Res. Soc. 16: 401, 1997.
151 Chesmel KD., Clark CC., Brighton CT., Black J.: Cellular responses to chemical and morphologic aspects of biomaterial surfaces. II. The biosynthetic and migratory response of bone cell populations. Journal of Biomedical Materials Research 29(9): 1101-10, Sep 1995.
137 Jones AR., Clark CC., Brighton CT.: Microvessel endothelial cells and pericytes increase proliferation and repress osteoblast phenotypic markers in rat calvarial bone cell cultures. Journal of Orthopaedic Research 13(4): 553-61, Jul 1995.
12b Bulman WA., Iannotti JP., Glowacki K., Bleuit J., Clark CC.: Serum fractions and related agonists with calcium-mobilizing activity in the bovine growth plate chondrocyte. Journal of Orthopaedic Research 13(2): 220-9, Mar 1995.
ce Nelson CL., Knight KZ., Clark CC.: The role of type I collagen in osteoblast differentiation. Trans. Orthop. Res. Soc. 20: 460, 1995.
139 Clark CC., Iannotti JP., Misra S., Richards CF.: Effects of thapsigargin, an intracellular calcium-mobilizing agent, on synthesis and secretion of cartilage collagen and proteoglycan. Journal of Orthopaedic Research 12(5): 601-11, Sep 1994.
133 Clark CC., Cohen I., Eichstetter I., Cannizzaro LA., McPherson JD., Wasmuth JJ., Iozzo RV.: Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Genomics 18(2): 249-60, Nov 1993.
ed Richardson DW., Clark CC.: Effects of short-term cast immobilization on equine articular cartilage. American Journal of Veterinary Research 54(3): 449-53, Mar 1993.
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Selected Publications
129 Li D., Clark CC., Myers JC.: Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells. Journal of Biological Chemistry 275(29): 22339-47, Jul 21 2000.110 Myers JC., Li D., Rubinstein NA., Clark CC.: Up-regulation of type XIX collagen in rhabdomyosarcoma cells accompanies myogenic differentiation. Experimental Cell Research 253(2): 587-98, Dec 15 1999.
d9 Jones AR., Brighton CT., Clark CC.: Collagen production by microvascular pericytes in long term culture. Trans. Orthop. Res. Soc. 16: 401, 1997.
151 Chesmel KD., Clark CC., Brighton CT., Black J.: Cellular responses to chemical and morphologic aspects of biomaterial surfaces. II. The biosynthetic and migratory response of bone cell populations. Journal of Biomedical Materials Research 29(9): 1101-10, Sep 1995.
137 Jones AR., Clark CC., Brighton CT.: Microvessel endothelial cells and pericytes increase proliferation and repress osteoblast phenotypic markers in rat calvarial bone cell cultures. Journal of Orthopaedic Research 13(4): 553-61, Jul 1995.
12b Bulman WA., Iannotti JP., Glowacki K., Bleuit J., Clark CC.: Serum fractions and related agonists with calcium-mobilizing activity in the bovine growth plate chondrocyte. Journal of Orthopaedic Research 13(2): 220-9, Mar 1995.
ce Nelson CL., Knight KZ., Clark CC.: The role of type I collagen in osteoblast differentiation. Trans. Orthop. Res. Soc. 20: 460, 1995.
139 Clark CC., Iannotti JP., Misra S., Richards CF.: Effects of thapsigargin, an intracellular calcium-mobilizing agent, on synthesis and secretion of cartilage collagen and proteoglycan. Journal of Orthopaedic Research 12(5): 601-11, Sep 1994.
133 Clark CC., Cohen I., Eichstetter I., Cannizzaro LA., McPherson JD., Wasmuth JJ., Iozzo RV.: Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Genomics 18(2): 249-60, Nov 1993.
ed Richardson DW., Clark CC.: Effects of short-term cast immobilization on equine articular cartilage. American Journal of Veterinary Research 54(3): 449-53, Mar 1993.
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