Karla Leavens, M.D., Ph.D.
Assistant Professor of Pediatrics (Endocrinology and Diabetes)
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
The Hub for Clinical Collaboration
Division of Endocrinology, 7th Floor
3500 Civic Center Blvd
Philadelphia, PA 19104
The Hub for Clinical Collaboration
Division of Endocrinology, 7th Floor
3500 Civic Center Blvd
Philadelphia, PA 19104
Office: 267-455-3727
Education:
BA (Biological Sciences)
Dartmouth College, 2003.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, 2010.
MD
University of Pennsylvania School of Medicine, 2012.
Permanent linkBA (Biological Sciences)
Dartmouth College, 2003.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, 2010.
MD
University of Pennsylvania School of Medicine, 2012.
Selected Publications
M. Craven, K. Lord, K. F. Leavens and D. D. De Leon: Insulin Immunoassay Interference Due to Human Antimouse Antibodies in a Patient With Ketotic Hypoglycemia. JCEM Case Reports 1(2), March 2023.Karla F Leavens, Juan R Alvarez-Dominguez, Linda T Vo, Holger A Russ, Audrey V Parent: Stem cell-based multi-tissue platforms to model human autoimmune diabetes. Molecular Metabolism 66: doi: 10.1016, Dec 2022 Notes: epub.
Tamaroff J, DeDio A, Wade K, Wells M, Park C, Leavens K, Rummey C, Kelly A, Lynch DR, McCormack SE: Friedreich's Ataxia related Diabetes: Epidemiology and management practices. Diabetes Res Clin Pract. 186: doi: 10.1016, March 2022 Notes: epub.
George MN, Leavens KF, Gadue P: Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers Front Endocrinol (Lausanne). 2: doi: 10.3389, June 2021 Notes: epub.
Wild KT, Nomakuchi TT, Sheppard SE, Leavens KF, De León DD, Zackai EH: Hyperinsulinism in an individual with an EP300 variant of Rubinstein-Taybi syndrome Am J Med Genet A 185(4): 1251-1255, April 2021.
Leavens KF and Wood A: Absent Thirst and Diabetes Insipidus. Diabetes Insipidus in Children, A Pocket Guide. Alter CA (eds.). Springer, 2021 Notes: Chapter.
Leavens KF, Liao CM, Gagne AL, Kishore S, Cardenas-Diaz FL, French DL, Gadue P: Generation of a double insulin and somatostatin reporter line, SCSe001-A-3, for the advancement of stem cell-derived pancreatic islets. Stem Cell Research 50(4): 102112, December 2020.
Cardenas-Diaz FL, Leavens KF, Kishore S, Osorio-Quintero C, Chen YJ, Stanger BZ, Wang P, French D, Gadue P: A Dual Reporter EndoC-βH1 Human β-Cell Line for Efficient Quantification of Calcium Flux and Insulin Secretion. Endocrinology 161(2): bqaa005, Feb 1 2020.
Chen YJ, Yamazoe T, Leavens KF, Cardenas-Diaz FL, Georgescu A, Huh D, Gadue P, Stanger BZ: iPreP is a three-dimensional nanofibrillar cellulose hydrogel platform for long-term ex vivo preservation of human islets. JCI Insight 4(21): e124644, Nov 1 2019.
Leavens KF, Stanley C: Hyperinsulinism. Decision Support in Medicine, Pediatrics 2019 Notes: Chapter.