Casey H. Halpern, MD

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Associate Professor of Neurosurgery
Department: Neurosurgery

Contact information
801 Spruce St
Philadelphia, PA 19106
Education:
BA (Classical Studies)
University of Pennsylvania, 2003.
MD (Medicine)
University of Pennsylvania, 2007.
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Description of Clinical Expertise

Dr. Halpern is Chief of Stereotactic and Functional Neurosurgery at the University of Pennsylvania. Dr. Halpern's clinical focus is in the treatment of movement disorders such as Parkinson's, tremor, dystonia, and Tourette, as well as epilepsy, and psychiatric disease. He has a particular interest in preclinical studies and developing clinical trials to expand indications for deep brain stimulation and other novel brain surgical therapies

Description of Research Expertise

Dr. Halpern researches human brain circuit mechanisms of mental health disease such as addiction, eating disorders and OCD as well as obesity, and uses his lab's innovations to develop targeted neuromodulatory interventions ranging from transcranial magnetic stimulation and deep bran stimulation to MR-guided focused ultrasound.

Selected Publications

Parvizi J, Veit MJ, Barbosa DAN, Kucyi A, Perry C, Parker JJ, Shivacharan RS, Chen F, Yih J, Gross JJ, Fisher R, McNab JA, Falco-Walter J, Halpern CH: Complex negative emotions induced by electrical stimulation of the human hypothalamus. Brain Stimul 15(3): 615-623, Apr 2022.

Ojukwu DI, Wang AR, Hornbeck TS, Lim EA, Sharrard J, Dhall R, Buch VP, Halpern CH: Conversion to Hybrid Deep Brain Stimulation System to Enable Multi-Contact Fractionation Can be Therapeutic. Movement Disorders 2022.

Mahajan UV, Ojukwu DI, Azagury DE, Safer DL, Cunningham T, Halpern CH: Can responsive deep brain stimulation be a cost-effective treatment for severe obesity? Obesity 2022.

Daniel A. N. Barbosa 1,2,9, Fiene Marie Kuijper1,9, Jeffrey Duda3, Allan R. Wang1, Samuel C. D. Cartmell1, Sabir Saluja1, Tricia Cunningham2, Rajat S. Shivacharan 2, Mahendra T. Bhati2,4, Debra L. Safer4, James D. Lock4, Robert C. Malenka 4,5, Ricardo de Oliveira-Souza6, Nolan R. Williams4, Murray Grossman7, James C. Gee3, Jennifer A. McNab8, Cara Bohon4 and Casey H. Halpern : Aberrant impulse control circuitry in obesity. Molecular Psychiatry 2022.

Wu H, Kakusa B, Neuner S, Christoffel DJ, Heifets BD, Malenka RC, Halpern CH: Local accumbens in vivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding. Proc Natl Acad Sci U S A 2022.

Kakusa B, Huang Y, Barbosa DAN, Feng A, Gattas S, Shivacharan R, Lee EB, Kuijper FM, Saluja S, Parker JJ, Miller KJ, Keller C, Bohon C, Halpern CH: Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain Neurobiol Dis 154: 105348, Jul 2021.

Pfeifer KJ, Kromer JA, Cook AJ, Hornbeck T, Lim EA, Mortimer BJP, Fogarty AS, Han SS, Dhall R, Halpern CH, Tass PA: Coordinated reset vibrotactile stimulation induces sustained cumulative benefits in Parkinson’s disease Front Physiol 12: 624317, Apr 2021 Notes: eCollection 2021.

Christoffel DJ, Walsh JJ, Heifets BD, Hoerbelt P, Neuner S, Sun G, Ravikumar VK, Wu H, Halpern CH, Malenka RC: Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding Nat Commun 12(1): 2135, Apr 2021.

Ojukwu D, Andruska K, Halpern CH: Lessons from George Floyd: Racial Inequalities in the Treatment of Parkinson's Disease Movement Disorders 36(3): 599-603, Mar 2021.

Wu H, Hariz M, Visser-Vandewalle V, Zrinzo L, Coenen VA, Sheth SA, Bervoets C, Naesström M, Blomstedt P, Coyne T, Hamani C, Slavin K, Krauss JK, Kahl KG, Taira T, Zhang C, Sun B, Toda H, Schlaepfer T, Chang JW, Régis J, Schuurman R, Schulder M, Doshi P, Mosley P, Poologaindran A, Lázaro-Muñoz G, Pepper J, Schechtmann G, Fytagoridis A, Huys D, Gonçalves-Ferreira A, D'Haese PF, Neimat J, Broggi G, Vilela-Filho O, Voges J, Alkhani A, Nakajima T, Richieri R, Djurfeldt D, Fontaine P, Martinez-Alvarez R, Okamura Y, Chandler J, Watanabe K, Barcia JA, Reneses B, Lozano A, Gabriëls L, De Salles A, Halpern CH*, Matthews K, Fins JJ, Nuttin B: Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Mol Psychiatry 26(1): 60-65, Jan 2021.

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Last updated: 06/08/2022
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