Casey H. Halpern, MD

faculty photo
Associate Professor of Neurosurgery
Division Head, Stereotactic and Functional Neurosurgery, University of Pennsylvania
Department: Neurosurgery
Graduate Group Affiliations

Contact information
801 Spruce St
Philadelphia, PA 19106
BA (Classical Studies)
University of Pennsylvania, 2003.
MD (Medicine)
University of Pennsylvania, 2007.
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Description of Clinical Expertise

Dr. Halpern is Chief of Stereotactic and Functional Neurosurgery at the University of Pennsylvania. Dr. Halpern's clinical focus is in the treatment of movement disorders such as Parkinson's, tremor, dystonia, and Tourette, as well as epilepsy, and psychiatric disease. He has a particular interest in preclinical studies and developing clinical trials to expand indications for deep brain stimulation and other novel brain surgical therapies

Description of Research Expertise

Dr. Halpern researches human brain circuit mechanisms of mental health disease such as addiction, eating disorders and OCD as well as obesity, and uses his lab's innovations to develop targeted neuromodulatory interventions ranging from transcranial magnetic stimulation and deep bran stimulation to MR-guided focused ultrasound.

Selected Publications

Huang Y, Wang JB, Parker JJ, Shivacharan R, Lal RA, Halpern CH.: Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity. Nat Commun 14(1): 2729, May 2023.

Youngerman BE, Banu MA, Khan F, McKhann GM, Schevon CA, Jagid JR, Cajigas I, Theodotou CB, Ko A, Buckley R, Ojemann JG, Miller JW, Laxton AW, Couture DE, Popli GS, Buch VP, Halpern CH, Le S, Sharan AD, Sperling MR, Mehta AD, Englot DJ, Neimat JS, Konrad PE, Sheth SA, Neal EG, Vale FL, Holloway KL, Air EL, Schwalb JM, D'Haese PF, Wu C.: Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre cohort study. J Neurol Neurosurg Psychiatry 2023.

Qiu L, Halpern CH, Barbosa DAN. : Are we getting closer to offering deep brain stimulation for treatment-resistant depression in clinical practice? Mol Psychiatry 2023.

West LC, Summers M, Tang S, Hirt L, Halpern CH, Maroni D, Das R, Gliske SV, Abosch A, Kushida CA, Thompson JA.: Evaluation of consensus sleep stage scoring of dysregulated sleep in Parkinson's disease. Sleep Med 2023.

Parker JJ, Rolle CE, Shivacharan RS, Barbosa DAN, Feng A, Huang Y, Kakusa BW, Prieto T, Jaffe RA, Williams NR, Halpern CH. : Appetitive Mapping of the Human Nucleus Accumbens. Biol Psychiatry 2023.

Krishna V, Fishman PS, Eisenberg HM, Kaplitt M, Baltuch G, Chang JW, Chang WC, Martinez Fernandez R, Del Alamo M, Halpern CH, Ghanouni P, Eleopra R, Cosgrove R, Guridi J, Gwinn R, Khemani P, Lozano AM, McDannold N, Fasano A, Constantinescu M, Schlesinger I, Dalvi A, Elias WJ. : Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson's Disease. N Engl J Med 2023.

Wong JK, Mayberg HS, Wang DD, Richardson RM, Halpern CH, Krinke L, Arlotti M, Rossi L, Priori A, Marceglia S, Gilron R, Cavanagh JF, Judy JW, Miocinovic S, Devergnas AD, Sillitoe RV, Cernera S, Oehrn CR, Gunduz A, Goodman WK, Petersen EA, Bronte-Stewart H, Raike RS, Malekmohammadi M, Greene D, Heiden P, Tan H, Volkmann J, Voon V, Li L, Sah P, Coyne T, Silburn PA, Kubu CS, Wexler A, Chandler J, Provenza NR, Heilbronner SR, Luciano MS, Rozell CJ, Fox MD, de Hemptinne C, Henderson JM, Sheth SA, Okun MS. : Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation. Front Hum Neurosci 2023.

Wang AR, Kuijper FM, Barbosa DAN, Hagan KE, Lee E, Tong E, Choi EY, McNab JA, Bohon C, Halpern CH. : Human habit neural circuitry may be perturbed in eating disorders. Sci Transl Med 2023.

Hitti FL, Widge AS, Riva-Posse P, Malone DA Jr, Okun MS, Shanechi MM, Foote KD, Lisanby SH, Ankudowich E, Chivukula S, Chang EF, Gunduz A, Hamani C, Feinsinger A, Kubu CS, Chiong W, Chandler JA, Carbunaru R, Cheeran B, Raike RS, Davis RA, Halpern CH, Vanegas-Arroyave N, Markovic D, Bick SK, McIntyre CC, Richardson RM, Dougherty DD, Kopell BH, Sweet JA, Goodman WK, Sheth SA, Pouratian N. : Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders. Brain Stimul. 2023.

Rijsketic DR, Casey AB, Barbosa DAN, Zhang X, Hietamies TM, Ramirez-Ovalle G, Pomrenze MB, Halpern CH, Williams LM, Malenka RC, Heifets BD.: UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice. Neuropsychopharmacology 2023.

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Last updated: 07/20/2023
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