Casey H. Halpern, MD

faculty photo
Associate Professor of Neurosurgery
Division Head, Stereotactic and Functional Neurosurgery, University of Pennsylvania
Department: Neurosurgery
Graduate Group Affiliations

Contact information
801 Spruce St
Philadelphia, PA 19106
Education:
BA (Classical Studies)
University of Pennsylvania, 2003.
MD (Medicine)
University of Pennsylvania, 2007.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Dr. Halpern is Chief of Stereotactic and Functional Neurosurgery at the University of Pennsylvania. Dr. Halpern's clinical focus is in the treatment of movement disorders such as Parkinson's, tremor, dystonia, and Tourette, as well as epilepsy, and psychiatric disease. He has a particular interest in preclinical studies and developing clinical trials to expand indications for deep brain stimulation and other novel brain surgical therapies

Description of Research Expertise

Dr. Halpern researches human brain circuit mechanisms of mental health disease such as addiction, eating disorders and OCD as well as obesity, and uses his lab's innovations to develop targeted neuromodulatory interventions ranging from transcranial magnetic stimulation and deep bran stimulation to MR-guided focused ultrasound.

Selected Publications

Qiu L, Chang A, Ma R, Strong TV, Okun MS, Foote KD, Wexler A, Gunduz A, Miller JL, Halpern CH: Neuromodulation for the treatment of Prader-Willi syndrome - A systematic review. Neurotherapeutics 21(3): e00339, April 2024.

Saluja S, Qiu L, Wang AR, Campos G, Selheimer R, McNab JA, Haber SN, Barbosa DAN, Halpern CH: Diffusion MRI tractography guides investigation of the zona incerta: a novel target for deep brain stimulation. Biol Psychiatry 3223(24): 01105-3, Feb 2024 Notes: [Online ahead of Print]

Nho YH, Rolle CE, Topalovic U, Shivacharan RS, Cunningham TN, Hiller S, Batista D, Feng A, Espil FM, Kratter IH, Bhati MT, Kellogg M, Raslan AM, Williams NR, Garnett J, Pesaran B, Oathes DJ, Suthana N, Barbosa DAN, Halpern CH: Responsive deep brain stimulation guided by ventral striatal electrophysiology of obsession durably ameliorates compulsion. Neuron 113(1): 73-83, Jan 2024.

Youngerman BE, Banu MA, Khan F, McKhann GM, Schevon CA, Jagid JR, Cajigas I, Theodotou CB, Ko A, Buckley R, Ojemann JG, Miller JW, Laxton AW, Couture DE, Popli GS, Buch VP, Halpern CH, Le S, Sharan AD, Sperling MR, Mehta AD, Englot DJ, Neimat JS, Konrad PE, Sheth SA, Neal EG, Vale FL, Holloway KL, Air EL, Schwalb JM, D'Haese PF, Wu C.: Long-term outcomes of mesial temporal laser interstitial thermal therapy for drug-resistant epilepsy and subsequent surgery for seizure recurrence: a multi-centre cohort study. J Neurol Neurosurg Psychiatry 94(11): 879-886, Nov 2023.

Jiang B, Ozkara BB, Creeden S, Zhu G, Ding VY, Chen H, Lanzman B, Wolman D, Shams S, Trinh A, Li Y, Khalaf A, Parker JJ, Halpern CH, Wintermark M.: Validation of a deep learning model for traumatic brain injury detection and NIRIS grading on non-contrast CT: a multi-reader study with promising results and opportunities for improvement. Neuroradiology 65(11): 1605-1617, Nov 2023.

Rijsketic DR, Casey AB, Barbosa DAN, Zhang X, Hietamies TM, Ramirez-Ovalle G, Pomrenze MB, Halpern CH, Williams LM, Malenka RC, Heifets BD.: UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice. Neuropsychopharmacology 48(12): 1798-1807, Nov 2023.

Eisinger RS, Okun MS, Cernera S, Cagle J, Beke M, Ramirez-Zamora A, Kim BH, Barbosa DAN, Qiu L, Vaswani P, Aamodt WW, Halpern CH, Foote KD, Gunduz A, Almeida L: Weight and survival after deep brain stimulation for Parkinson's disease. Parkinsonism Relat Disord 115: 105810, Oct 2023.

Xu E, Stone SL, Zhong Y, Golenberg N, Qiu L, Abdullaev Z, Aldape K, Bagley L, Halpern CH, Amankulor N, Nasrallah MP.: A novel ARIH1::BRAF fusion in a glioma. J Neuropathol Exp Neurol 82(11): 966-969, Oct 2023.

Modi P, Qiu L, Fallah T, Courtwright A, Halpern CH: Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Treatment of Severe Essential Tremor in a Lung Transplant Recipient-A Case Report. Transplant Proc 55(8): 1988-1990, Oct 2023.

Barbosa DAN, Gattas S, Salgado JS, Kuijper FM, Wang AR, Huang Y, Kakusa B, Leuze C, Luczak A, Rapp P, Malenka RC, Hermes D, Miller KJ, Heifets BD, Bohon C, McNab JA, Halpern CH.: An orexigenic subnetwork within the human hippocampus. Nature 621(7978): 381-388, Sep 2023.

back to top
Last updated: 06/17/2024
The Trustees of the University of Pennsylvania