Casey H. Halpern, MD
Associate Professor of Neurosurgery
Division Head, Stereotactic and Functional Neurosurgery, University of Pennsylvania
Attending, Cpl Michael J. Crescenz VA Medical Center, University of Pennsylvania
Department: Neurosurgery
Graduate Group Affiliations
Contact information
Pennsylvania Hospital
Department of Neurosurgery
801 Spruce Street
Philadelphia, PA 19106
Department of Neurosurgery
801 Spruce Street
Philadelphia, PA 19106
Education:
BA (Classical Studies)
University of Pennsylvania, 2003.
MD (Medicine)
University of Pennsylvania, 2007.
Permanent linkBA (Classical Studies)
University of Pennsylvania, 2003.
MD (Medicine)
University of Pennsylvania, 2007.
Description of Clinical Expertise
Dr. Halpern is Chief of Stereotactic and Functional Neurosurgery at the University of Pennsylvania. Dr. Halpern's clinical focus is in the treatment of movement disorders such as Parkinson's, tremor, dystonia, and Tourette, as well as epilepsy, and psychiatric disease. He has a particular interest in preclinical studies and developing clinical trials to expand indications for deep brain stimulation and other novel brain surgical therapiesDescription of Research Expertise
Dr. Halpern researches human brain circuit mechanisms of mental health disease such as addiction, eating disorders and OCD as well as obesity, and uses his lab's innovations to develop targeted neuromodulatory interventions ranging from transcranial magnetic stimulation and deep bran stimulation to MR-guided focused ultrasound.Selected Publications
Saluja S, Qiu L, Wang AR, Campos G, Selheimer R, McNab JA, Haber SN, Barbosa DAN, Halpern CH: Diffusion MRI tractography guides investigation of the zona incerta: a novel target for deep brain stimulation. Biol Psychiatry 96(6): 445-454, Sep 2024.Kellogg MA, Ernst LD, Spencer DC, Datta P, Klein E, Bhati MT, Shivacharan RS, Nho YH, Barbosa DAN, Halpern CH, Raslan A: Dual Treatment of Refractory Focal Epilepsy and Obsessive-Compulsive Disorder With Intracranial Responsive Neurostimulation. Neurol Clin Pract 14(4): e200318, Aug 2024.
Qiu L, Chang A, Ma R, Strong TV, Okun MS, Foote KD, Wexler A, Gunduz A, Miller JL, Halpern CH: Neuromodulation for the treatment of Prader-Willi syndrome - A systematic review. Neurotherapeutics 21(3): e00339, April 2024.
Nho YH, Rolle CE, Topalovic U, Shivacharan RS, Cunningham TN, Hiller S, Batista D, Feng A, Espil FM, Kratter IH, Bhati MT, Kellogg M, Raslan AM, Williams NR, Garnett J, Pesaran B, Oathes DJ, Suthana N, Barbosa DAN, Halpern CH: Responsive deep brain stimulation guided by ventral striatal electrophysiology of obsession durably ameliorates compulsion. Neuron 113(1): 73-83, Jan 2024.
Younghoon Nho, Liming Qiu, Robert S. Seilheimer, Altona Tufanoglu, Bryan Wilent, David W. Oslin, Katherine W. Scangos, Anna-Rose Childress, Casey H. Halpern: Deep brain stimulation of the nucleus accumbens reduces cue-hyperreactivity electrophysiological marker associated with opioid craving. SfN2024 Poster Presented by Younghoon Nho 2024.
Min Jae Kim, Liming Qiu1, Gustavo Campos1, Maya Alexis1, Daniel A.N. Barbosa,1,2,Iahn Cajigas,1 Casey H. Halpern1,3: Characterizing Differential Tremor “Sweetspots” and Side Effect “Sourspots” following Thalamic High-Intensity Focused Ultrasound through Probabilistic Lesion Mapping. ASSFN poster presented by Min Jae Kim 2024.
Younghoon Nho, Liming Qiu1, Gustavo Campos1, Rob Seilheimer2, Camarin Rolle3, Lily Brown2, Desmond Oathes2, Bijan Pesaran1, Katherine Scangos1, Daniel Barbosa1, Casey H. Halpern 1: An intracranial EEG biomarker derived from provocation tasks is modulated by stimulation of the ventral striatum to alleviate OCD-related distress. BRAIN Poster presented by Younghoon Nho 2024.
Liming Qiu, Y Nho1, R Seilheimer2, A Tufanoglu2, DW Oslin2,3, KW Scangos1, AR Childress2, CH Halpern1,4: Personalized Evocation of Cue-hyperreactivity May Optimize Deep Brain Stimulation for Opioid Use Disorder. ASSFN Poster presented by Liming Qiu 2024.
Andrew Chang, Jakob Michiels2, Daniel A.N. Barbosa1,3, Gustavo Campos1, Ashley Koluda2, Younghoon Nho1, Liming Qiu1, Robert L. Seilheimer4, Wonkyung Choi2, Romain Duprat4, Aaron D. Boes5,6,7, Nicholas T. Trapp7, Hiroyuki Oya8, Desmond J. Oathes4, Roy H. Hamilton9, Flavia Vitale2,9,10,11,12, Casey H. Halpern1,13: Safety of Transcranial Magnetic Stimulation in Patients with Deep Brain Electrodes: Gel Phantom Brain Testing. ASSFN Poster presented by Andrew Chang 2024.
Wonkyung Choi, Younghoon Nho2, W. Bryan Wilent2, Nida Firdous2, Andrew Chang2, Gustavo Campos2, David Bakalov1, Liming Qiu2, Robert Seilheimer3, Isaac Jonathan Pomeraniec2, Marie Kerr2, Disha Joshi2, Anastassia Amaro5, Matthew R. Hayes3,7, Iahn Cajigas2, Bijan Pesaran2, Kelly C. Allison3, Joshua I Gold6, Thomas A. Wadden3, Casey H. Halpern2,4: Action of Glucagon-like Peptide-1 (GLP-1)/Gastric Inhibitory Polypeptide (GIP)-Receptor Dual-Agonism on Food Preoccupations Involves Low Frequency Oscillations within the Human Nucleus Accumbens. ASSFN poster presented by Wonkyung Choi 2024.