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Casey H. Halpern, MD
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Professor of Neurosurgery
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Division Head, Stereotactic and Functional Neurosurgery, University of Pennsylvania
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Attending, Cpl Michael J. Crescenz VA Medical Center, University of Pennsylvania
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Department: Neurosurgery
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- Neuroscience e
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Contact information
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Pennsylvania Hospital
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34 801 Spruce Street
Philadelphia, PA 19106
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22 Department of Neurosurgery
34 801 Spruce Street
Philadelphia, PA 19106
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Education:
21 7 BA 1e (Classical Studies) c
33 University of Pennsylvania, 2003.
21 7 MD 15 (Medicine) c
33 University of Pennsylvania, 2007.
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Permanent link21 7 BA 1e (Classical Studies) c
33 University of Pennsylvania, 2003.
21 7 MD 15 (Medicine) c
33 University of Pennsylvania, 2007.
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Description of Clinical Expertise
1ca Dr. Halpern is Chief of Stereotactic and Functional Neurosurgery at the University of Pennsylvania. Dr. Halpern's clinical focus is in the treatment of movement disorders such as Parkinson's, tremor, dystonia, and Tourette, as well as epilepsy, and psychiatric disease. He has a particular interest in preclinical studies and developing clinical trials to expand indications for deep brain stimulation and other novel brain surgical therapies71
Description of Research Expertise
159 Dr. Halpern researches human brain circuit mechanisms of mental health disease such as addiction, eating disorders and OCD as well as obesity, and uses his lab's innovations to develop targeted neuromodulatory interventions ranging from transcranial magnetic stimulation and deep bran stimulation to MR-guided focused ultrasound.e 29
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1a6 Nho Y†, Qiu L†, Seilheimer RL, Campos G, Chang A, Wang Z, Magnotti JF, Beauchamp MS, Barbosa DAN, Horn A, Williams NR, Brown LA, Ganguly TM, Cristancho M, Pesaran B, Oathes DJ, Miller KJ, Scangos KW*, Halpern CH*. : Human orbitobfrontal neural activity is linked to obsessive-compulsive behavioral dynamics.[accepted for publication] Cell 2025.
8c Choi, W.;† Nho, Y.;† Qiu, L.; Chang, A.; Campos, G.; Seilheimer, R.L.; Wilent, W.B; Bakalov, 61 D.; Firdous, N.; Kerr, M.; Joshi, D.; Maze, G.; Topalovic, U.; Batista, D.; Suthana, N.; Amaro, 60 A.; Hayes, M.R.; Cajigas, I.; Cristancho, M.; Allison, K.C.; Pesaran, B.; Scangos, K.W.; Gold, 6a J.I.; Wadden, T.A.; Halpern, C.H.: Brain activity associated with breakthrough food preoccupation 5e in an individual on tirzepatide. Nature Medicine 2025 Notes: accepted.
183 Buch VP, Purger D, Datta A, Wang A, Barbosa D, Chodakiewitz Y, Lev-Tov L, Li C, Halpern C, Henderson J, McNab JA, Bitton RR, Ghanouni P.: "Quality over quantity:" smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor. Front Neruol Nov 2024.
165 Qiu L, Pomeraniec IJ, Howard SD, Ajmera S, Bagley LJ, Cajigas I, Kennedy BC, Halpern CH.: Intraprocedural Three-Dimensional Imaging Registration Optimizes Magnetic Resonance Imaging-Guided Focused Ultrasound and Facilitates Novel Applications. Oper Neurosurg 29(2): 281-287, Nov 2024.
c1 Kaplitt MG, Krishna V, Eisenberg HM, Elias WJ, Ghanouni P, Baltuch GH, Rezai A, Halpern CH, Dalm B, Fishman PS, Buch VP, Moosa S, Sarva H, Murray AM. c1 : Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor: An Open-Label Clinical Trial. JAMA Neurol 81(9): 939-946, Sep 2024.
100 Saluja S, Qiu L, Wang AR, Campos G, Selheimer R, McNab JA, Haber SN, Barbosa DAN, Halpern CH: Diffusion MRI tractography guides investigation of the zona incerta: a novel target for deep brain stimulation. 42 Biol Psychiatry 96(6): 445-454, Sep 2024.
16b Kellogg MA, Ernst LD, Spencer DC, Datta P, Klein E, Bhati MT, Shivacharan RS, Nho YH, Barbosa DAN, Halpern CH, Raslan A: Dual Treatment of Refractory Focal Epilepsy and Obsessive-Compulsive Disorder With Intracranial Responsive Neurostimulation. Neurol Clin Pract 14(4): e200318, Aug 2024.
126 Qiu L, Chang A, Ma R, Strong TV, Okun MS, Foote KD, Wexler A, Gunduz A, Miller JL, Halpern CH: Neuromodulation for the treatment of Prader-Willi syndrome - A systematic review. Neurotherapeutics 21(3): e00339, April 2024.
1c7 Nho YH, Rolle CE, Topalovic U, Shivacharan RS, Cunningham TN, Hiller S, Batista D, Feng A, Espil FM, Kratter IH, Bhati MT, Kellogg M, Raslan AM, Williams NR, Garnett J, Pesaran B, Oathes DJ, Suthana N, Barbosa DAN, Halpern CH: Responsive deep brain stimulation guided by ventral striatal electrophysiology of obsession durably ameliorates compulsion. Neuron 113(1): 73-83, Jan 2024.
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Selected Publications
aa Seeber M, Stangl M, Vallejo Martelo M, Topalovic U, Hiller S, Halpern CH, Langevin JP, Rao VR, Fried I, Eliashiv D, Suthana N. 47 : Human neural dynamics of real-world and imagined navigation. 43 Nat Hum Behav. 9(4): 781-793. April 2025.1a6 Nho Y†, Qiu L†, Seilheimer RL, Campos G, Chang A, Wang Z, Magnotti JF, Beauchamp MS, Barbosa DAN, Horn A, Williams NR, Brown LA, Ganguly TM, Cristancho M, Pesaran B, Oathes DJ, Miller KJ, Scangos KW*, Halpern CH*. : Human orbitobfrontal neural activity is linked to obsessive-compulsive behavioral dynamics.[accepted for publication] Cell 2025.
8c Choi, W.;† Nho, Y.;† Qiu, L.; Chang, A.; Campos, G.; Seilheimer, R.L.; Wilent, W.B; Bakalov, 61 D.; Firdous, N.; Kerr, M.; Joshi, D.; Maze, G.; Topalovic, U.; Batista, D.; Suthana, N.; Amaro, 60 A.; Hayes, M.R.; Cajigas, I.; Cristancho, M.; Allison, K.C.; Pesaran, B.; Scangos, K.W.; Gold, 6a J.I.; Wadden, T.A.; Halpern, C.H.: Brain activity associated with breakthrough food preoccupation 5e in an individual on tirzepatide. Nature Medicine 2025 Notes: accepted.
183 Buch VP, Purger D, Datta A, Wang A, Barbosa D, Chodakiewitz Y, Lev-Tov L, Li C, Halpern C, Henderson J, McNab JA, Bitton RR, Ghanouni P.: "Quality over quantity:" smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor. Front Neruol Nov 2024.
165 Qiu L, Pomeraniec IJ, Howard SD, Ajmera S, Bagley LJ, Cajigas I, Kennedy BC, Halpern CH.: Intraprocedural Three-Dimensional Imaging Registration Optimizes Magnetic Resonance Imaging-Guided Focused Ultrasound and Facilitates Novel Applications. Oper Neurosurg 29(2): 281-287, Nov 2024.
c1 Kaplitt MG, Krishna V, Eisenberg HM, Elias WJ, Ghanouni P, Baltuch GH, Rezai A, Halpern CH, Dalm B, Fishman PS, Buch VP, Moosa S, Sarva H, Murray AM. c1 : Safety and Efficacy of Staged, Bilateral Focused Ultrasound Thalamotomy in Essential Tremor: An Open-Label Clinical Trial. JAMA Neurol 81(9): 939-946, Sep 2024.
100 Saluja S, Qiu L, Wang AR, Campos G, Selheimer R, McNab JA, Haber SN, Barbosa DAN, Halpern CH: Diffusion MRI tractography guides investigation of the zona incerta: a novel target for deep brain stimulation. 42 Biol Psychiatry 96(6): 445-454, Sep 2024.
16b Kellogg MA, Ernst LD, Spencer DC, Datta P, Klein E, Bhati MT, Shivacharan RS, Nho YH, Barbosa DAN, Halpern CH, Raslan A: Dual Treatment of Refractory Focal Epilepsy and Obsessive-Compulsive Disorder With Intracranial Responsive Neurostimulation. Neurol Clin Pract 14(4): e200318, Aug 2024.
126 Qiu L, Chang A, Ma R, Strong TV, Okun MS, Foote KD, Wexler A, Gunduz A, Miller JL, Halpern CH: Neuromodulation for the treatment of Prader-Willi syndrome - A systematic review. Neurotherapeutics 21(3): e00339, April 2024.
1c7 Nho YH, Rolle CE, Topalovic U, Shivacharan RS, Cunningham TN, Hiller S, Batista D, Feng A, Espil FM, Kratter IH, Bhati MT, Kellogg M, Raslan AM, Williams NR, Garnett J, Pesaran B, Oathes DJ, Suthana N, Barbosa DAN, Halpern CH: Responsive deep brain stimulation guided by ventral striatal electrophysiology of obsession durably ameliorates compulsion. Neuron 113(1): 73-83, Jan 2024.
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