Giorgos C Karakousis, MD
The Emilie and Roland T. deHellenbranth Professor in Surgery II
Attending Staff Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Full Researcher Member, Abramson Cancer Center, University of Pennsylvania Health System, Philadelphia, PA
Chair, Cancer Committee, Abramson Cancer Center, Perelman School of Medicine, Philadelphia, PA
Site Co-Team Leader, Melanoma Disease, Abramson Cancer Center, Penn Medicine, Philadelphia, PA
Chief, Division of Endocrine & Oncologic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Department: Surgery
Contact information
Division of Endocrine & Oncologic Surgery
Hospital of the University of Pennsylvania
3400 Spruce St., 4 Silverstein
Philadelphia, PA 19104
Hospital of the University of Pennsylvania
3400 Spruce St., 4 Silverstein
Philadelphia, PA 19104
Office: 215-662-2083
Fax: 215-662-7476
Fax: 215-662-7476
Education
BS, MS (Molecular Biophysics and Biochemistry)
Yale University, 1996.
MD
University of Pennsylvania School of Medicine, 2001.
Permanent linkBS, MS (Molecular Biophysics and Biochemistry)
Yale University, 1996.
MD
University of Pennsylvania School of Medicine, 2001.
Selected Publications
Acker RC, Sharpe J, Williams S, Landau S, Rowe J, Fraker D, Karakousis GC, Wachtel H, Kelz RR.: ASO Visual Abstract: Comparing Resident Team Performance in Complex Surgical Oncology: A Single-Institution Cohort Study. Ann Surg Oncol Jun 2026.Simons RA, Vargas GM, Farooq MS, Miura JT, Karakousis GC.: 2025 CPT Code Revisions Will Have a Significant Impact on the Classification of Retroperitoneal Sarcoma Resection. J Am Coll Surg 242: 1696-1698, Jun 2026.
Tsingas K, Thomas M, Reale M, Xiao M, Wickramasinghe J, Chen Y, Duong B, Lucas A, Thacker G, Li H, Mou H, Ramirez-Salazar E, Elbasir A, Villanueva J, Xu X, Flowers A, Karakousis GC, Miura JT, Mitchell TC, Amaravadi RK, Schuchter LM, Liu S, Long Q, Hoon DSB, Ramos RI, Catbagan JJ, Bustos MA, Gershenwald JE, Simon JM, Wargo JA, Davies MA, Lu Y, Mills GB, Cohen S, Lawless A, Sharova T, Frederick DT, Flaherty KT, Hacohen N, Boland GM, Auslander N, Herlyn M.: Melanoma-patient-derived xenograft multi-omics resource melPDomiX maps gain- and loss-of-function alterations. Cell Rep 45: 117455, Jun 2026.
Farooq MS, Jona A, Vargas GM, Simons RA, Miura JT, Karakousis GC, Etherington MS.: Patient selection, practice patterns, and perioperative outcomes for robotic splenectomy: a contemporary ACS-NSQIP analysis. Surg Endosc Jun 2026.
Liu S, Rook AH, Huang AC, Maity A, Qin Z, Chen Y, Song D, Deng Y, Huang Z, Karakousis GC, Mitchell TC, Amaravadi RK, Schuchter LM, Binder ZA, O'Rourke DM, Herlyn M, Guo W, Xu X.: Topical resiquimod elicits systemic protection and improves anti-PD1 therapy in melanoma via priming of CD8+ T cells. Cancer Immunol Res Jun 2026.
Acker RC, Sharpe JE, Williams S, Landau SI, Rowe J, Fraker D, Karakousis GC, Wachtel H, Kelz RR.: Comparing Resident Team Performance in Complex Surgical Oncology: A Single-Institution Cohort Study. Ann Surg Oncol Jun 2026.
Karakousis G.: Pre-operative Radiation for Resectable Retroperitoneal Sarcoma: Where are we With Risk-benefit Calculus? Ann Surg May 2026.
Kapoor D, Shaikh U, Valdes-Morales K, Trifoi MD, Lin SK, Deitermann AM, Banala M, Zhang E, Easo N, Lubeck M, Haynes D, Lewis D, Nugent ST, Etzkorn JR, Jariwala NN, Zhang J, Walker JL, Higgins HW 2nd, Sobanko JF, Giordano CN, Daneshpajouhnejad P, Modi M, Lin IC, Chang B, Wink J, Karakousis G, Miura J, Miller CJ.: Response to Xu et al., "Letter to Editor 'Mohs micrographic surgery reduces the risk of reconstruction with positive margins, repeat surgeries, and time to definitive reconstruction compared to conventional excision of hand and foot melanomas: A retrospective cohort study'" J Am Acad Dermatol Apr 2026.
Wei S, Deng Y, Lee J, Lan H, Yang Z, Labrie M, Betts CB, Duan H, Tate B, Pucilowska J, Frederick D, Lawless AR, Sharova T, Yang Y, Hu W, Beasley GM, Schuchter LM, Wang X, Xu W, Yong G, Vandenberg MEG, Torigian DA, Sivagnanam S, Du K, Sugarman E, McGettigan S, Zheng C, Al-Rohil RN, Selim MA, Datto MB, López GY, Nair SK, Ashley DM, Xu X, Amaravadi RK, Karakousis GC, O'Rourke DM, Brem S, O'Malley BW, Demirkan G, Yu S, Lu Y, Camp T, Patterson JA, Wei Z, Corless C, Gabrilovich DI, Mou Y, Flaherty KT, Coussens LM, Boland G, Herlyn M, Mills G, Liu L, Zhang G.: A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma. Cell Rep Med 7: 102716, Apr 2026.
Wang SY, Turner G, Valdes-Morales KL, Hunter ER, Kim M, Tran VA, Polen K, Haynes D, Miller CJ, Etzkorn JR, Sobanko JF, Walker JL, Zhang J, Brody RM, Cannady SB, Rajasekaran K, Farwell DG, Miura JT, Karakousis GC, Lukens JR, Amaravadi RK, Schuchter LM, Mitchell TC, Higgins HW 2nd, Carey RM.: Accuracy of Sentinel Lymph Node Biopsy to Predict Nodal Metastasis in Head and Neck Merkel Cell Carcinoma. JAMA Otolaryngol Head Neck Surg 152: 313-322, Mar 2026.