Michele E. Paessler, D.O.

Professor of Clinical Pathology and Laboratory Medicine
Hematopathologist, Children's Hospital of Philadelphia
Medical Director, Clinical Immunology Lab, Children's Hospital of Philadelphia
Associate Director, Clinical Hematology Laboratory , The Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine
Contact information
3401 Civic Center Boulevard
Department of Laboratory and Pathology
Suite 5199D
Philadelphia, PA 19104
Department of Laboratory and Pathology
Suite 5199D
Philadelphia, PA 19104
Office: 267-426-7309
Fax: 215-590-2130
Fax: 215-590-2130
Email:
paessler@email.chop.edu
paessler@email.chop.edu
Education:
B.S.
Muhlenberg College (with honors), Allentown, PA, 1993.
D.O.
Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 1997.
Permanent linkB.S.
Muhlenberg College (with honors), Allentown, PA, 1993.
D.O.
Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 1997.
Selected Publications
Grant LMC, Bellissimo DC, Katz AJ, Daou AW, Margolskee E, Bernt KM, Piccione J: Hodgkin Lymphoma Diagnosed by Endobronchial Ultrasound Guided Cryobiopsy, a Minimally Invasive Diagnostic Technique. Pediatr Pulmonol 60(1): e27392, January 2025.Kim D, Margolskee E, Goyal A, Siddiqui MT, Heymann JJ, Rao R, Hayden J: Optimal Carcinoembryonic Antigen (CEA) Cutoff Values in the Diagnosis of Neoplastic Mucinous Pancreatic Cysts Differ Among Assays. J Clin Pathol 77(12): 848-852, November 2024.
Gallo PM, Kim J, McNerney KO, Diorio C, Foley C, Kagami L, Wagner K, Petrosa WL, Conlon H, Gollomp KL, Canna SW, Seif AE, Conrad MA, Kelsen JR, Romberg N, Bassiri H, Sullivan KE, Teachey DT, Paessler ME, Behrens EM, Lambert MP: Serum Cytokine Panels in Pediatric Clinical Practice J Allergy Clin Immunol September 2024 Notes: Online ahead of print.
Lin F, Cao K, Chang F, Oved JH, Luo M, Fan Z, Schubert J, Wu J, Zhong Y, Gallo DJ, Denenberg EH, Chen J, Fanning EA, Lambert MP, Paessler ME, Surrey LF, Zelley K, MacFarland S, Kurre P, Olson TS, Li MM: Uncovering the Genetic Etiology of Inherited Bone Marrow Failure Syndromes Using a Custom-Designed Next-Generation Sequencing Panel. J Mol Diagn 26(3): 191-201, March 2024.
Drumheller B, Gebre K, Lockhart B, Margolskee E, Obstfeld A, Paessler M, Pillai V: Haematology laboratory parameters to assess efficacy of CD19-, CD22-, CD33-, and CD123-directed chimeric antigen receptor T-cell therapy in haematological malignancies. International Journal of Laboratory Hematology 44(4): 750-758, August 2022.
Wing A, Xu J, Meng W, Rosenfeld AM, Li EY, Wertheim G, Paessler M, Bagg A, Frank D, Tn K, Teachey DT, Lim MS, Luning Prak E, Fajgenbaum DC, Pillai V: Transcriptome and Unique Cytokine Microenvironment of Castleman Disease. Modern Pathology 35(4): 451-461, April 2022.
Dolan JG, Paessler ME, Rheingold SR, Pillai V: Hematopathologic Correlates of CAR T-Cell Therapy. Clinics in Laboratory Medicine 41(3): 325-339, September 2021.
Si S, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE: Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis. Journal of Clinical Immunology. Springer Nature, 41(6): 1213-1218, August 2021.
Triebwasser MP, Barrett DM, Bassiri H, Bunin N, Elgarten C, Freedman J, Geera AS, Monos D, Lambert MP, Olson T, Seif AE, Paessler M, Petrosa W, Anne F Reilly, Romberg N, Sullivan KE, Quinn GZ, Behrens E, Teachey DT : Combined Use of Emapalumab and Ruxolitinib in a Patient with Refractory Hemophagocytic Lymphohistiocytosis was Safe and Effective. Pediatric Blood and Cancer 68(7), July 2021.
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT: Evidence of Thrombotic Microangiopathy in Children with SARS-CoV-2 Across the Spectrum of Clinical Presentations. Blood Advances 23(4): 6051-6063, December 2020.