Michele E. Paessler, D.O.

faculty photo
Associate Professor of Clinical Pathology and Laboratory Medicine
Hematopathologist, Children's Hospital of Philadelphia
Medical Director, Clinical Immunology Lab, Children's Hospital of Philadelphia
Associate Director, Clinical Hematology Laboratory , The Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine

Contact information
3401 Civic Center Boulevard
Department of Laboratory and Pathology
Suite 5199D
Philadelphia, PA 19104
Office: 267-426-7309
Fax: 215-590-2130
Education:
B.S.
Muhlenberg College (with honors), Allentown, PA, 1993.
D.O.
Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 1997.
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Selected Publications

Wing A, Xu J, Meng W, Rosenfeld AM, Li EY, Wertheim G, Paessler M, Bagg A, Frank D, Tn K, Teachey DT, Lim MS, Luning Prak E, Fajgenbaum DC, Pillai V: Transcriptome and Unique Cytokine Microenvironment of Castleman Disease. Modern Pathology 35(4): 451-461, April 2022.

Drumheller B, Gebre K, Lockhart B, Margolskee E, Obstfeld A, Paessler M, Pillai V: Haematology laboratory parameters to assess efficacy of CD19-, CD22-, CD33-, and CD123-directed chimeric antigen receptor T-cell therapy in haematological malignancies. International Journal of Laboratory Hematology 44(4): 750-758, August 2022.

Dolan JG, Paessler ME, Rheingold SR, Pillai V: Hematopathologic Correlates of CAR T-Cell Therapy. Clinics in Laboratory Medicine 41(3): 325-339, September 2021.

Si S, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE: Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis. Journal of Clinical Immunology. Springer Nature, 41(6): 1213-1218, August 2021.

Triebwasser MP, Barrett DM, Bassiri H, Bunin N, Elgarten C, Freedman J, Geera AS, Monos D, Lambert MP, Olson T, Seif AE, Paessler M, Petrosa W, Anne F Reilly, Romberg N, Sullivan KE, Quinn GZ, Behrens E, Teachey DT : Combined Use of Emapalumab and Ruxolitinib in a Patient with Refractory Hemophagocytic Lymphohistiocytosis was Safe and Effective. Pediatric Blood and Cancer 68(7), July 2021.

Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT: Evidence of Thrombotic Microangiopathy in Children with SARS-CoV-2 Across the Spectrum of Clinical Presentations. Blood Advances 23(4): 6051-6063, December 2020.

Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John AR, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H : Multisystem Inflammatory Syndrome in Children and COVID-19 are Distinct Presentations of SARS-CoV-2. The Journal of Clinical Investigation 130(11): 5967-5975, November 2020.

Diorio C, Shaw PA, Pequignot E, Orlenko A, Chen F, Aplenc R, Barrett DM, Bassiri H, Behrens E, DiNofia AM, Gonzalez V, Koterba N, Levine BL, Maude SL, Meyer NJ, Moore JH, Paessler M, Porter DL, Bush JL, Siegel DL, Davis MM, Zhang D, June CH, Grupp SA, Melenhorst JJ, Lacey SF, Weiss SL, Teachey DT: Diagnostic Biomarkers to Differentiate Sepsis from Cytokine Release Syndrome in Critically Ill Children Blood Advances 4(20): 5174-5183, October 2020.

Pillai V, Muralidharan K, Meng W, Bagashev A, Oldridge DA, Rosenthal J, Van Arnam J, Melenhorst JJ, Mohan D, DiNofia AM, Luo M, Cherian S, Fromm JR, Wertheim G, Thomas-Tikhonenko A, Paessler M, June CH, Luning Prak ET, Bhoj VG, Grupp SA, Maude SL, Rheingold SR: CAR T-cell Therapy is Effective for CD 19-dim B-lymphoblastic Leukemia but is Impacted by Prior Blinatumomab Therapy. Blood Advances 3(22): 3539-3549, November 2019.

Gerhart J, Behling K, Paessler M, Milton L, Bramblett G, Garcia D, Pitts M, Hurtt R, Crawford M, Lackman R, Nguyen D, Infanti J, FitzGerald P, George-Weinstein M: Rhabdomyosarcoma and Wilms Tumors Contain a Subpopulation of Noggin Producing, Myogenic Cells Immunoreactive for Lens Beaded Filament Proteins. PLoS One 14(4): e0214758, April 2019.

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Last updated: 09/28/2023
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