Julia C. Tchou, M.D., Ph.D.

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Professor of Clinical Surgery
Attending surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Breast Cancer Research Program Steering Committee, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Department: Surgery

Contact information
Division of Endocrine & Oncologic Surgery
3400 Civic Center Boulevard
Perelman Center, 3rd Floor West
Philadelphia, PA 19104-4283
Office: 215-615-7575
College of Mount Saint Vincent, Riverdale, NY, 1987.
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 1993.
State University of New York at Stony Brook School of Medicine, Stony Brook, NY, 1995.
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Description of Research Expertise

My research is focused on 1) developing strategies to mitigate breast cancer risk associated with metabolic syndrome by lifestyle modifications and by re-purposing some of the commonly prescribed medications to prevent breast cancer initiation and progression; 2) elucidating how novel immunotherapy such as CAR T therapy can induce epitope spreading and how combination therapy can unleash the anti-tumor effects of our own immune system; and 3) how we can use large data to enhance our understanding of tumor biology with the common goal of improving breast cancer outcomes.

Description of Clinical Expertise

Dr. Tchou’s practice focuses on the interdisciplinary management of patients with breast cancer: coordinating pre-operative evaluation, surgery and post-operative care of men and women with malignant breast diseases.

Selected Publications

Hoffman DI, Zhang PJ, Tchou J: Breast-conserving surgery for pure non-classic lobular carcinoma in situ: A single institution's experience. Surgical Oncology 28: 190-194, Mar. 2019 Notes: (Epub Jan. 24, 2019).

Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F: Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Nature Communications 10(1): 130, Jan. 10 2019.

Williams AD, Reyes SA, Arlow RL, Tchou J, De La Cruz LM: Is age trumping genetic profiling in clinical practice? Relationship of chemotherapy recommendation and oncotype DX recurrence score in patients aged < 50 years versus ≥ 50 years, and trends over time. Annals of Surgical Oncology 25(10): 2875-2883, Oct. 2018 Notes: (Epub June 29, 2018).

Williams AD, Li YR, So A, Steel L, Carrigan E, Ro V, Nguyen J, Tchou J: The impact of aspirin use on breast cancer subtype and clinical course. Journal of Surgical Research 230: 71-79, Oct. 2018 Notes: (Epub May 25, 2018).

Williams AD, So A, Tchou J: Overall survival is similar between women who seek care at one or more institutions after diagnosis of operable breast cancer in the community. Surgical Oncology 27(3): 387-391, Sept. 2018 Notes: (Epub May 26, 2018).

Modarressi T, Levine MA, Tchou J, Khan AN: Gestational gigantomastia complicated by PTHrP-mediated hypercalcemia. Journal of Clinical Endocrinology & Metabolism 103(9): 3124-3130, Sept. 1 2018 Notes: Epub July 18, 2018.

Yoon-Flannery K, DeStefano LM, De La Cruz LM, Fisher CS, Lin LY, Coffua LS, Mustafa RE, Sataloff DM, Tchou JC, Brooks AD: Quality of life and sexual well-being after nipple sparing mastectomy: A matched comparison of patients using the breast Q. Journal of Surgical Oncology 118(1): 238-242, July 2018 Notes: (Epub Aug. 16, 2018).

So Alycia, De La Cruz Lucy M, Williams Austin D, Bahng Joseph, Liao Geraldine, McDonald Elizabeth S, Fisher Carla S, Czerniecki Brian J, Sataloff Dahlia, Tchou Julia: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. Journal of Surgical Oncology 117(4): 558-566, Mar. 2018 Notes: (Epub Nov. 11, 2017).

Jakub James W, Peled Anne Warren, Gray Richard J, Greenup Rachel A, Kiluk John V, Sacchini Virgilio, McLaughlin Sarah A, Tchou Julia C, Vierkant Robert A, Degnim Amy C, Willey Shawna: Oncologic safety of prophylactic nipple-sparing mastectomy in a population with BRCA mutations: A multi-institutional study. JAMA Surgery 153(2): 123-129, Feb. 1 2018 Notes: (Epub Sept. 2017).

Williams AD, Payne KK, Posey AD Jr, Hill C, Conejo-Garcia J, June CH, Tchou J: Immunotherapy for breast cancer: Current and future strategies. Current Surgical Reports 5: pii: 31, Dec. 2017 Notes: (Epub Oct. 10, 2017).

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Last updated: 06/22/2022
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