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Irwin Lucki, PhD
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Emeritus Professor of Psychology in Psychiatry
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Director, Behavioral Psychopharmacology Laboratory, University of Pennsylvania
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Department: Psychiatry
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Contact information
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Department of Psychiatry
22 University of Pennsylvania
37 2204 Translational Research Laboratory Building
3d 125 South 31st Street
Philadelphia, PA 19104-3403
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22 University of Pennsylvania
37 2204 Translational Research Laboratory Building
3d 125 South 31st Street
Philadelphia, PA 19104-3403
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Office: 215-573-3305
32 Fax: 215-573-2149
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32 Fax: 215-573-2149
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Email:
lucki@mail.med.upenn.edu
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lucki@mail.med.upenn.edu
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Publications
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Links
96 Search PubMed for articles
41 Pharmacological Sciences graduate group faculty webpage.
7a Neuropsychopharmacology Training Program
3e Neuroscience graduate group faculty webpage.
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96 Search PubMed for articles
41 Pharmacological Sciences graduate group faculty webpage.
7a Neuropsychopharmacology Training Program
3e Neuroscience graduate group faculty webpage.
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Education:
21 9 B.A. 17 (Psychology) c
2f University of Illinois, 1972.
21 9 M.A. 17 (Psychology) c
2b University of Iowa, 1976.
21 a Ph.D. 1a (Biopsychology) c
2b University of Iowa, 1979.
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Permanent link21 9 B.A. 17 (Psychology) c
2f University of Illinois, 1972.
21 9 M.A. 17 (Psychology) c
2b University of Iowa, 1976.
21 a Ph.D. 1a (Biopsychology) c
2b University of Iowa, 1979.
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9e (1) Behavioral pharmacology; (2) Mechanism of action of antidepressant and antianxiety medications; (3) Stress neurobiology and psychiatric disorders
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12 KEY WORDS:
5e Antidepressants; tranquilizers; stress; serotonin; microdialysis; knockouts; behavior
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1b RESEARCH TECHNIQUES
180 Behavioral pharmacology in rats and mice; microdialysis measurement of extracellular concentrations of monoamines in conscious rats and mice; behavioral analysis of knockout mice; stereotaxic surgery; effects of brain lesions and neurotoxins on behavior; central drug administration; in vitro ligand binding; histology; radioimmunoassay; and HPLC analysis of brain monoamines
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18 RESEARCH SUMMARY
50d Current studies focus on the role of specific neurotransmitters, such as serotonin (5-HT), in the behavioral effects of antidepressant and anxiolytic drugs. Animal models for depression and anxiety are used to evaluate the potential efficacy of different neurotransmitter and peptide receptors for clinical therapeutic effects, to identify brain regions associated with behavioral responses to drugs, and to construct and evaluate pharmacological models for improving the efficacy of psychiatric medications. The participation of central 5-HT neurotransmission in depression, anxiety and neuroendocrine regulation associated with behavioral stress is specifically being investigated. Microdialysis procedures are used to measure the release of neurotransmitters in discrete regions of awake freely-moving rats or mice. These studies provide information on the regulation of the release of neurotransmitters in different brain regions, determine environmental and behavioral conditions that alter the release of neurotransmitters, and measure the effects of drugs during behavioral performance. Finally, studies of different inbred mouse strains or knockout mice are examining genetic factors associated with complex behaviors and the behavioral effects of psychotherapeutic medications.
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Description of Research Expertise
23 RESEARCH INTERESTS9e (1) Behavioral pharmacology; (2) Mechanism of action of antidepressant and antianxiety medications; (3) Stress neurobiology and psychiatric disorders
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12 KEY WORDS:
5e Antidepressants; tranquilizers; stress; serotonin; microdialysis; knockouts; behavior
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1b RESEARCH TECHNIQUES
180 Behavioral pharmacology in rats and mice; microdialysis measurement of extracellular concentrations of monoamines in conscious rats and mice; behavioral analysis of knockout mice; stereotaxic surgery; effects of brain lesions and neurotoxins on behavior; central drug administration; in vitro ligand binding; histology; radioimmunoassay; and HPLC analysis of brain monoamines
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18 RESEARCH SUMMARY
50d Current studies focus on the role of specific neurotransmitters, such as serotonin (5-HT), in the behavioral effects of antidepressant and anxiolytic drugs. Animal models for depression and anxiety are used to evaluate the potential efficacy of different neurotransmitter and peptide receptors for clinical therapeutic effects, to identify brain regions associated with behavioral responses to drugs, and to construct and evaluate pharmacological models for improving the efficacy of psychiatric medications. The participation of central 5-HT neurotransmission in depression, anxiety and neuroendocrine regulation associated with behavioral stress is specifically being investigated. Microdialysis procedures are used to measure the release of neurotransmitters in discrete regions of awake freely-moving rats or mice. These studies provide information on the regulation of the release of neurotransmitters in different brain regions, determine environmental and behavioral conditions that alter the release of neurotransmitters, and measure the effects of drugs during behavioral performance. Finally, studies of different inbred mouse strains or knockout mice are examining genetic factors associated with complex behaviors and the behavioral effects of psychotherapeutic medications.
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103 Falcon, E., Maier, K., Robinson, S.A. and Lucki, I. : Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice Psychopharmacology 232: 907-915, 2015.
ee Browne, C.A., van Nest, D. and Lucki, I. : Antidepressant-like effects of buprenorphine in rats are strain dependent Behavioural Brain Research 278: 385-392, 2015.
111 Ho, N., Brookshire, B.R., Clark, J.E. and Lucki, I. : Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice. Metabolic Brain Disease 30: 555-562, 2015.
172 Arnold, S.E., Lucki, I., Brookshire, B.R., Carlson, G.C., Browne, C.A., Kazi, H., Bang, S., Choi, B.-R., Chen, Y., McMullen, M.F. and Kim, S.F. : High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of Disease 67: 79-87, 2014.
153 Santini, M.A., Balu, D.T., Hill-Smith, T.E., Lucki, I., Mikkelsen, J.D. and Coyle, J.T. : D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI Behavioural Brain Research 259: 242-246, 2014.
ed Carlin, J., Hill-Smith, T.E., Lucki, I. and Reyes, T.M. : Reversal of dopamine system dysfunction in response to high fat diet Obesity 21(12): 2513-21, Dec 2013.
120 Featherstone, R., Tatard-Leitman, V., Suh, J., Lin, R., Lucki, I. and Siegel, S: Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression Psychopharmacology 227: 639-649, 2013.
11c Balu, D.T., Turner, J.R., Brookshire, B.R. Hill, T.E., Blendy, J.A. and Lucki, I: Brain monoamines and responses to antidepressant drugs in MRL/MpJ versus C57BL/6J and mice Neuropharmacology 67: 503-510, 2013.
147 Multani, P.K., Hodge, R., Estevez, M., Abel, T., Kung, H., Choi, S., Talbot, K., Brookshire, B., Lucki, I., Nall, A.H., Doyle, G.A. and Lohoff, F.W.: VMAT1 deletion causes hippocampal apoptosis and neurocognitive deficits Neuroscience 232C: 32-44, 2012.
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Selected Publications
146 Snyder, K.P., Hill-Smith, T.E., Lucki, I. and Valentino, R.J. : Corticotropin-releasing factor in the rat dorsal raphe nucleus promotes different forms of behavioral flexibility depending on social stress history. Neuropsychopharmacology 2015, in press.103 Falcon, E., Maier, K., Robinson, S.A. and Lucki, I. : Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice Psychopharmacology 232: 907-915, 2015.
ee Browne, C.A., van Nest, D. and Lucki, I. : Antidepressant-like effects of buprenorphine in rats are strain dependent Behavioural Brain Research 278: 385-392, 2015.
111 Ho, N., Brookshire, B.R., Clark, J.E. and Lucki, I. : Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice. Metabolic Brain Disease 30: 555-562, 2015.
172 Arnold, S.E., Lucki, I., Brookshire, B.R., Carlson, G.C., Browne, C.A., Kazi, H., Bang, S., Choi, B.-R., Chen, Y., McMullen, M.F. and Kim, S.F. : High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of Disease 67: 79-87, 2014.
153 Santini, M.A., Balu, D.T., Hill-Smith, T.E., Lucki, I., Mikkelsen, J.D. and Coyle, J.T. : D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI Behavioural Brain Research 259: 242-246, 2014.
ed Carlin, J., Hill-Smith, T.E., Lucki, I. and Reyes, T.M. : Reversal of dopamine system dysfunction in response to high fat diet Obesity 21(12): 2513-21, Dec 2013.
120 Featherstone, R., Tatard-Leitman, V., Suh, J., Lin, R., Lucki, I. and Siegel, S: Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression Psychopharmacology 227: 639-649, 2013.
11c Balu, D.T., Turner, J.R., Brookshire, B.R. Hill, T.E., Blendy, J.A. and Lucki, I: Brain monoamines and responses to antidepressant drugs in MRL/MpJ versus C57BL/6J and mice Neuropharmacology 67: 503-510, 2013.
147 Multani, P.K., Hodge, R., Estevez, M., Abel, T., Kung, H., Choi, S., Talbot, K., Brookshire, B., Lucki, I., Nall, A.H., Doyle, G.A. and Lohoff, F.W.: VMAT1 deletion causes hippocampal apoptosis and neurocognitive deficits Neuroscience 232C: 32-44, 2012.
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