E. Paul Wileyto, Ph.D.

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Adjunct Associate Professor of Biostatistics in Biostatistics and Epidemiology
Director of the Data Management and Biostatistics Core, Center for Interdisciplinary Research on Nicotine Addiction (CIRNA), Department of Psychiatry, University of Pennsylvania School of Medicine
Senior Research Investigator, Department of Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology

Contact information
Department of Biostatistics, Epidemiology, and Informatics
University of Pennsylvania
Perelman School of Medicine
Room 619 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-2319
Fax: 215-573-4865
B.S. (Botany)
University of Wisconsin, Madision, WI, 1977.
M..S. (Botany)
McGill University, Montreal, PQ, Canada, 1979.
Ph.D. (Ecology)
University of Pennsylvania, 1990.
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Description of Research Expertise

Dr. Wileyto is an Assistant Professor of Biostatistics in the Department of Psychiatry at the University of Pennsylvania's Health Systems, and the Biostatistician for the Penn Transdisciplinary Tobacco Use Research Center. His primary responsibilities include collaborative analysis of data, experimental design, grant writing, and development and testing of outcome measures for smoking cessation research. He has a secondary responsibility for education and training of staff in statistical methods, use of statistical software, and data management issues related to analysis. Dr. Wileyto is also engaged in ongoing collaborative statistical work with the Radiation Oncology Department, helping to analyze the spatial relationship of tumor hypoxia with blood supply from images.

Dr. Wileyto's research interests lie in applications of mathematical statistics in biology and medicine. Before joining the TTURC, he worked in the Section of Epidemiology and Public Health for the University of Pennsylvania's School of Veterinary Medicine at the New Bolton Center on population dynamics and epidemiology of Lyme disease. During this time, he conducted the largest case-control study ever done on Lyme disease. Dr. Wileyto also conducted innovative methodological work in the statistical estimation of population size from trap data at the USDA Stored Product Insects Laboratory.

Dr. Wileyto received his Ph.D. in Ecology from the University of Pennsylvania (Department of Biology), and completed a post-doctoral fellowship in Mathematical Epidemiology at Johns Hopkins University's School of Hygiene. He has a secondary appointment in the University of Pennsylvania Medical School's Department of Biostatistics, and is an Associate Scholar in the Center for Clinical Epidemiology and Biostatistics.

Selected Publications

Wileyto EP, Patterson F, Niaura R, Epstein LH, Brown RA, Audrain-McGovern J, Hawk LW Jr, Lerman C: Recurrent Event Analysis of Lapse and Recovery in a Smoking Cessation Clinical Trial Utilizing Bupropion. Nicotine & Tobacco Research 7(2): 257-68, Apr 2005.

Strasser AA, Kaufmann V, Jepson C, Perkins KA, Pickworth WB, Wileyto EP, Rukstalis M, Audrain-McGovern J, Lerman C: Effects of Different Nicotine Replacement Therapies on Post-Cessation Psychological Responses. Addictive Behaviors 30(1): 9-17, Jan 2005.

Audrain-McGovern J., Lerman C., Wileyto EP., Rodriguez D., Shields PG.: Interacting effects of genetic predisposition and depression on adolescent smoking progression. American Journal of Psychiatry 161(7): 1224-30, Jul 2004.

Wileyto P., Patterson F., Niaura R., Epstein L., Brown R., Audrain-McGovern J., Hawk L., Lerman C., Patterson F.: Do small lapses predict relapse to smoking behavior under bupropion treatment? Nicotine & Tobacco Research 6(2): 357-66, Apr 2004.

Wileyto EP., Audrain-McGovern J., Epstein LH., Lerman C.: Using logistic regression to estimate delay-discounting functions. Behavior Research Methods, Instruments, & Computers 36(1): 41-51, Feb 2004.

Collins BN., Wileyto EP., Patterson F., Rukstalis M., Audrain-McGovern J., Kaufmann V., Pinto A., Hawk L., Niaura R., Epstein LH., Lerman C.: Gender differences in smoking cessation in a placebo-controlled trial of bupropion with behavioral counseling. Nicotine & Tobacco Research 6(1): 27-37, Feb 2004.

Audrain-McGovern J., Rodriguez D., Tercyak KP., Epstein LH., Goldman P., Wileyto EP.: Applying a behavioral economic framework to understanding adolescent smoking. Psychology of Addictive Behaviors 18(1): 64-73, Mar 2004.

Evans SM., Judy KD., Dunphy I., Jenkins WT., Nelson PT., Collins R., Wileyto EP., Jenkins K., Hahn SM., Stevens CW., Judkins AR., Phillips P., Geoerger B., Koch CJ.: Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding. Cancer Research 64(5): 1886-92, Mar 1 2004.

Lerman, C., Wileyto, E.P., Patterson, F., Rukstalis, M., Audrain-McGovern, J., Restine, S., Shields, P.G., Kaufmann, V., Redden, D., Benowitz, N., & Berrettini, W.H. : The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. Pharmacogenomics Journal 4: 184-192, 2004.

Lerman, C., Berrettini, W., Pinto, A., Patterson, F., Crystal-Mansour, S., Wileyto, E.P., Restine, S.L., Leonard, D.G., Shields, P.G., & Epstein, L.H. : Changes in food reward following smoking cessation: a pharmacogenetic investigation. Psychopharmacology 174: 571-577, 2004.

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Last updated: 04/26/2023
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