David S Frankel, MD

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania
Director, Cardiac Electrophysiology Fellowship Program, Hospital of the University of Pennsylvania
Associate Director, Cardiac Electrophysiology Laboratories, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Pavilion at the Hospital of the University of Pennsylvania
1 Convention Ave
2nd Floor, City Side
Philadelphia, PA 19104
Office: 215-662-6801
Fax: 215-615-4350
BA (American History)
University of Pennsylvania, College of Arts and Sciences, Philadelphia, PA, 2000.
University of Pennsylvania, School of Medicine, Philadelphia, PA, 2004.
Permanent link
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Description of Clinical Expertise

ventricular tachycardia
atrial fibrillation
catheter ablation
supraventricular tachycardia
cardiac resynchronization therapy

Description of Research Expertise

ventricular tachycardia
atrial fibrillation
catheter ablation
supraventricular tachycardia
pacing-induced cardiomyopathy
cardiac resynchronization therapy

Selected Publications

Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z.: Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell Metab 34: 1749-1764, Nov 2022.

Walsh KA, Daw JM, Lin A, Guandalini G, Hyman MC, Kumareswaran R, Arkles JS, Schaller RD, Supple GE, Frankel DS, Nazarian S, Riley MP, Garcia F, Lin D, Tschabrunn C, Dixit S, Epstein AE, Callans DJ, Marchlinski FE, Santangeli P.: Characterization of the right ventricular substrate participating in postinfarction ventricular tachycardia. Heart Rhythm Oct 2022.

Griffiths JR, Nussinovitch U, Liang JJ, Sims R, Yoneda ZT, Bernstein HM, Viswanathan MN, Khairy P, Srivatsa UN, Frankel DS, Marchlinski FE, Sandhu A, Shoemaker MB, Mohanty S, Burkhardt JD, Natale A, Lakireddy D, De Groot NMS, Gerstenfeld EP, Moore JP, Ávila P, Ernst S, Nguyen DT.: Catheter Ablation for Atrial Fibrillation in Adult Congenital Heart Disease: An International Multicenter Registry Study. Circ Arrhythm Electrophysiol Sep 2022.

Tschabrunn CM, Frankel DS.: Diving beneath the surface to maximize ablation lesion size. J Interv Card Electrophysiol Aug 2022.

Amankwah NA, Pothineni NVK, Guandalini G, Santangeli P, Schaller R, Supple GE, Deo R, Nazarian S, Lin D, Epstein AE, Dixit S, Callans DJ, Marchlinski FE, Frankel DS.: Impact of atrial fibrillation recurrences during the blanking period following catheter ablation on long-term arrhythmia-free survival: a prospective study with continuous monitoring. J Interv Card Electrophysiol Jul 2022.

Kalluri AG, Sugrue A, Frankel DS.: An Important Cause of Wide Complex Tachycardia. JAMA Intern Med 182: 670-671, Jun 2022.

Markman TM, Folse E, Yang L, Groeneveld PW, Frankel DS.: Trends in Opioid Use After Cardiac Implantable Electronic Device Procedures in the United States Between 2004 and 2020. Circulation 145: 1499-1501, May 2022.

Smietana J, Supple GE, Frankel DS, Schaller RD, Lin D, Marchlinski FE, Santangeli P.: Continuous Pericardial Irrigation-Suction Technique to Manage Hemorrhagic Pericardial Effusion Associated With Loculated Intrapericardial Thrombus. JACC Clin Electrophysiol May 2022.

Markman TM, Pothineni NVK, Zghaib T, Smietana J, McBride D, Amankwah NA, Linn KA, Kumareswaran R, Hyman M, Arkles J, Santangeli P, Schaller RD, Supple GE, Frankel DS, Deo R, Lin D, Riley MP, Epstein AE, Callans DJ, Marchlinski FE, Hamilton R, Nazarian S.: Effect of Transcutaneous Magnetic Stimulation in Patients With Ventricular Tachycardia Storm: A Randomized Clinical Trial. JAMA Cardiol 7: 445-449, Apr 2022.

Pothineni NVK, Cherian T, Patel N, Smietana J, Frankel DS, Deo R, Epstein AE, Marchlinski FE, Schaller RD.: Subcutaneous Implantable Cardioverter-defibrillator Explantation-A Single Tertiary Center Experience. J Innov Card Rhythm Manag 13: 4947-4953, Apr 2022.

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Last updated: 11/17/2022
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