Han-Chiao Isaac Chen, MD

faculty photo
Assistant Professor of Neurosurgery at the Presbyterian Medical Center of Philadelphia and the Veteran's Administration Medical Center
Department: Neurosurgery
Graduate Group Affiliations

Contact information
The Hospital of the University of Pennsylvania
Department of Neurosurgery
3rd Floor, Silverstein Pavilion
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.3487
Lab: 215.898.7945
BA (Biochemical Sciences)
Harvard University, 2002.
University of Pennsylvania, 2007.
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Description of Clinical Expertise

Dr. Chen's clinical interests include functional neurosurgery (i.e., deep brain stimulation and epilepsy surgery), the resection of tumors in and around eloquent brain tissue, and traumatic brain injury. With respect to clinical research, he works on developing new techniques for mapping brain function and identifying targets for neuro-modulatory and brain circuit reconstruction interventions.

Description of Research Expertise

Dr. Chen is interested in developing novel approaches to brain repair, specifically with respect to the reconstruction of cortical circuitry. His laboratory combines techniques from neural tissue engineering, stem cell biology, and neural interface technologies to generate structured neural and axonal tissue for transplantation. In the in vivo setting, he studies the factors that promote neural tissue survival and integration and the functional effect of this tissue on large-scale neuronal networks.

Selected Publications

Chen HI, Attiah M, Baltuch G, Smith DH, Hamilton RH, Lucas TH: Harnessing plasticity for the treatment of neurosurgical disorders. World Neurosurgery 82(5): 648-659, 2014.

Chen HI, Bohman L, Loevner L, Lucas TH: Transorbital endoscopic amygdalo-hippocampectomy: a feasibility investigation. Journal of Neurosurgery 120(6): 1428-1436, 2014 Notes: Cover article.

Chen HI, Berman JI, Hudgins ED, Wolf RL, Lucas TH: Correlation of cortical and subcortical motor mapping with DTI- and HARDI-based tractography. Congress of Neurological Surgeons 2014 Notes: Poster Presentation

Chen HI, Wolf JA, Smith DH: Development of biological data cable: optogenetic-based transmission across engineered cortical axonal tracts. Society for Neuroscience 2012 Notes: Poster Presentation

Chen HI, Stiefel MF, Oddo M, Milby AH, Maloney-Wilensky E, Frangos S, Levine JM, Kofke WA, LeRoux PD: Detection of cerebral compromise with multimodality monitoring in patients with subarachnoid hemorrhage. Neurosurgery 69(1): 53-63, July 2011.

Evans SM, Jenkins KT, Chen HI, Jenkins WT, Judy KD, Hwang WT, Lustig RA, Magarelli DR, Judkins A, Grady MS, Hahn SM, Koch CJ: The relationship among hypoxia, proliferation, and outcome in patients with de novo glioblastoma: A pilot study. Translational Oncology 3(3): 160-169, 2010.

Oddo M, Milby A, Chen HI, Frangos S, MacMurtrie E, Maloney-Wilensky E, Stiefel MF, Kofke WA, Levine JM, LeRoux PD: Hemoglobin concentration and cerebral metabolism in patients with aneurysmal subarachnoid hemorrhage. Stroke 40(4): 1275-1281, 2009.

Chen HI, Malhotra NR, Oddo M, Heuer GG, Levine JM, LeRoux PD: Barbiturate infusion for intractable intracranial hypertension and its effects on brain oxygenation. Neurosurgery 63(5): 880-886, 2008.

Chen HI, Bakshi A, Royo NC, Magge SN, Watson DJ: Neural stem cells as biological minipumps: A faster route to cell therapy for the CNS? Current Stem Cell Research and Therapy 2(1): 13-22, 2007.

Royo NC, LeBold D, Magge SN, Chen HI, Hauspurg A, Cohen AS, Watson DJ: Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience 148(2): 359-370, 2007.

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Last updated: 01/16/2019
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