Han-Chiao Isaac Chen, MD
Department of Neurosurgery
3rd Floor, Silverstein Pavilion
3400 Spruce Street
Philadelphia, PA 19104
BA (Biochemical Sciences)
Harvard University, 2002.
University of Pennsylvania, 2007.
Description of Clinical ExpertiseDr. Chen's clinical interests include functional neurosurgery (i.e., deep brain stimulation and epilepsy surgery), the resection of tumors in and around eloquent brain tissue, and traumatic brain injury. With respect to clinical research, he works on developing new techniques for mapping brain function and identifying targets for neuro-modulatory and brain circuit reconstruction interventions.
Description of Research ExpertiseDr. Chen is interested in developing novel approaches to brain repair, specifically with respect to the reconstruction of cortical circuitry. His laboratory combines techniques from neural tissue engineering, stem cell biology, and neural interface technologies to generate structured neural and axonal tissue for transplantation. In the in vivo setting, he studies the factors that promote neural tissue survival and integration and the functional effect of this tissue on large-scale neuronal networks.
Selected PublicationsChen HI, Jgamadze D, Lim J, Mensah-Brown K, Wolf JA, Mills JA, Smith DH: Functional cortical axon tracts generated from human stem cell-derived neurons. Tissue Engineering, Part A 25(9-10): 736-45, 2019.
Chen HI, Ming GL, Song H: Applications of cerebral organoids to clinical problems. Developmental Dynamics 248(1): 53-64, 2019.
Piazza M*, Hitti FL*, Sinha S, Kvint S, Hudgins E, Baltuch G, Diaz-Arrastia R, Litt B, Davis KA, Lucas TH, Chen HI: Surgical outcomes in post-traumatic epilepsy: a single institutional experience. Operative Neurosurgery 18(1): 12-18, 2020.
Ulyanova AV, Koch, PF, Cottone C, Grovola MR, Adam CD, Browne KD, Weber M, Russo RJ, Gagnon K, Smith DH, Chen HI, Johnson VE, Cullen DK, Wolf JA: Electrophysiological signature reveals laminar structure of the porcine hippocampus. eNeuro 5(5): ENEURO.0102-18.2018, September 2018.
Liaudanskaya V*, Jgamadze D*, Berk AN, Bischoff D, Gu BJ, Hawks-Mayer H, Whalen M, Chen HI^, Kaplan DL^ (*co-first author, ^co-senior author): Engineering advanced neural tissue to mitigate acute cerebral inflammation after brain transplantation in rats. Biomaterials 192: 510-522, 2018.
Buch V, Yang AI, Lucas TL, Chen HI: Closed-loop stimulation methods: Current practice and future promise (Chapter 7). Deep Brain Stimulation: Techniques and Practice. Anderson W (eds.). 2018.
Struzyna LA, Browne KD, Brodnik ZD, Burrell JC, Harris JP, Chen HI, Wolf JA, Duda JE, Espana RA, Cullen DK: Transplantable dopaminergic micro-tissue engineered neural networks to recapitulate the nigrostriatal pathway in Parkinson’s disease. Journal of Tissue Engineering and Regenerative Medicine 12(7): 1702-1716, July 2018.
Goel NJ, Mallela AN, Agarwal P, Abdullah KG, Choudhri OA, Kung DK, Lucas TH, Chen HI: Complications predicting perioperative mortality in patients undergoing elective craniotomy: an ACS-NSQIP analysis. World Neurosurgery 118: e195-e205, 2018.
Chen HI, Wolf JA, Smith DH: Multichannel activity propagation across an engineered axon network. Journal of Neural Engineering 14(2): 026016, 2017.
Chen HI, Jgamadze D, Serruya, MD, Cullen DK, Wolf JA, Smith DH: Neural substrate expansion for the restoration of brain function. Frontiers in Systems Neuroscience 10: 1, Jan 2016 Notes: eCollection 2016; doi: 10.3389/fnsys.2016.00001.