Geoffrey Karl Aguirre, MD, PhD
3400 Spruce Street
Philadelphia, PA 19104
Princeton University, 1992.
University of Pennsylvania, 2000.
University of Pennsylvania, 2001.
Description of Research ExpertiseI study human cortical organization for vision, and how this organization is altered by neurologic and ophthalmologic disease. Human visual cortex is composed of early, “retinotopically” organized visual areas, as well as more specialized, “categorical” areas that process specific visual features (such as facial appearance). My work has varied along two dimensions within this research space: scale and perturbation. I have examined the organization of visual cortex from its large-scale, anatomical arrangement to the precise and subtle form of population neural coding for object features. These studies at different scales of cortical organization have further been conducted both in healthy controls as well as in patients for whom visual function has been perturbed by retinal disease or cerebral dysfunction. I make use of a variety of scientific techniques, although the majority of my research uses BOLD fMRI, which is a non-invasive measure of neural activity in human participants.
Description of Clinical ExpertiseMy sub-speciality in Behavioral Neurology, and I treat patients with a variety of disturbances of visual perception, thinking and memory.
Description of Other ExpertiseResident Education
I am an Associate Director of the Neurology Residency Program for the University of Pennsylvania. My focus is on the scholarly and research activities of the residents. I direct the "research firm" which is an ongoing educational program covering career development, research methodology, and the responsible conduct of research.
Selected PublicationsMcAdams Harrison, Igdalova Aleksandra, Spitschan Manuel, Brainard David H, Aguirre Geoffrey K: Pulses of Melanopsin-Directed Contrast Produce Highly Reproducible Pupil Responses That Are Insensitive to a Change in Background Radiance. Investigative ophthalmology & visual science 59(13): 5615-5626, Nov 2018.
Mattar Marcelo G, Olkkonen Maria, Epstein Russell A, Aguirre Geoffrey K: Adaptation decorrelates shape representations. Nature communications 9(1): 3812, september 2018.
Mattar Marcelo G, Wymbs Nicholas F, Bock Andrew S, Aguirre Geoffrey K, Grafton Scott T, Bassett Danielle S: Predicting future learning from baseline network architecture. NeuroImage 172: 107-117, May 2018.
Irwin David J, McMillan Corey T, Xie Sharon X, Rascovsky Katya, Van Deerlin Vivianna M, Coslett H Branch, Hamilton Roy, Aguirre Geoffrey K, Lee Edward B, Lee Virginia M Y, Trojanowski John Q, Grossman Murray: Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a journal of neurology 141(1): 288-301, Jan 2018.
Spitschan Manuel, Bock Andrew S, Ryan Jack, Frazzetta Giulia, Brainard David H, Aguirre Geoffrey K: The human visual cortex response to melanopsin-directed stimulation is accompanied by a distinct perceptual experience. Proceedings of the National Academy of Sciences of the United States of America 114(46): 12291-12296, November 2017.
Olkkonen Maria, Aguirre Geoffrey K, Epstein Russell A: Expectation modulates repetition priming under high stimulus variability. Journal of vision 17(6): 10, Jun 2017.
Aguirre Geoffrey K, Butt Omar H, Datta Ritobrato, Roman Alejandro J, Sumaroka Alexander, Schwartz Sharon B, Cideciyan Artur V, Jacobson Samuel G: Postretinal Structure and Function in Severe Congenital Photoreceptor Blindness Caused by Mutations in the GUCY2D Gene. Investigative ophthalmology & visual science 58(2): 959-973, Feb 2017.
Downs Louise M, Scott Erin M, Cideciyan Artur V, Iwabe Simone, Dufour Valerie, Gardiner Kristin L, Genini Sem, Marinho Luis Felipe, Sumaroka Alexander, Kosyk Mychajlo S, Swider Malgorzata, Aguirre Geoffrey K, Jacobson Samuel G, Beltran William A, Aguirre Gustavo D: Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation. Human molecular genetics 25(19): 4211-4226, Oct 2016.
Mattar Marcelo G, Kahn David A, Thompson-Schill Sharon L, Aguirre Geoffrey K: Varying Timescales of Stimulus Integration Unite Neural Adaptation and Prototype Formation. Current biology : CB 26(13): 1669-1676, July 2016.
Spitschan Manuel, Aguirre Geoffrey K, Brainard David H, Sweeney Alison M: Variation of outdoor illumination as a function of solar elevation and light pollution. Scientific reports 6: 26756, Jun 2016.