Geoffrey Karl Aguirre, MD, PhD

faculty photo
Associate Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
Department of Neurology
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3390
Education:
BA (Politics)
Princeton University, 1992.
PhD (Neuroscience)
University of Pennsylvania, 2000.
MD
University of Pennsylvania, 2001.
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Description of Research Expertise

I study human cortical organization for vision, and how this organization is altered by neurologic and ophthalmologic disease. Human visual cortex is composed of early, “retinotopically” organized visual areas, as well as more specialized, “categorical” areas that process specific visual features (such as facial appearance). My work has varied along two dimensions within this research space: scale and perturbation. I have examined the organization of visual cortex from its large-scale, anatomical arrangement to the precise and subtle form of population neural coding for object features. These studies at different scales of cortical organization have further been conducted both in healthy controls as well as in patients for whom visual function has been perturbed by retinal disease or cerebral dysfunction. I make use of a variety of scientific techniques, although the majority of my research uses BOLD fMRI, which is a non-invasive measure of neural activity in human participants.

Description of Clinical Expertise

My sub-speciality in Behavioral Neurology, and I treat patients with a variety of disturbances of visual perception, thinking and memory.

Description of Other Expertise

Resident Education

I am an Associate Director of the Neurology Residency Program for the University of Pennsylvania. My focus is on the scholarly and research activities of the residents. I direct the "research firm" which is an ongoing educational program covering career development, research methodology, and the responsible conduct of research.

Selected Publications

Patterson Gentile C, Aguirre GK: A neural correlate of visual discomfort from flicker. Journal of Vision 20(7), Jul 2020 Notes: Journal of Vision is an online, open access, peer-reviewed scientific journal

McAdams H, Kaiser EA, Igdalova A, Haggerty EB, Cucchiara B, Brainard DH, Aguirre GK: Selective amplification of ipRGC signals accounts for interictal photophobia in migraine. Proceedings of the National Academy of Sciences of the United States of America 117(29): 1730-17329, July 2020.

Grewal JS, Gloe T, Hegedus J, Bitterman K, Billings BK, Chengetanai S, Bentil S, Wang VX, Ng JC, Tang CY, Geletta S, Wicinski B, Bertelson M, Tendler BC, Mars RB, Aguirre GK, Rusbridge C, Hof PR, Sherwood CC, Manger PR, Spocter MA: Brain gyrification in wild and domestic canids: Has domestication changed the gyrification index in domestic dogs? Journal of Comparative Neurology Jun 2020 Notes: [published online ahead of print, 2020 Jun 27]

C Workman, S Humphries, F Hartung, GK Aguirre, J Kable, A Chatterjee : Morality is in the eye of the beholder: Unpacking the neurocognitive basis of the “anomalous-is-bad” stereotype. (submitted) 2020.

R Cooper, GK Aguirre, J Morgan: Fully-Automated Estimation of Spacing and Density for Retinal Mosaics. Translational Vision Science & Technology 2020.

NF Darwich, JM Phan, B Kim, E Suh, JD Papatriantafyllou, L Changolkar, AT Nguyen, C O’Rourke, Z He, S Porta, GS Gibbons, KC Luk, SG Papageorgiou, M Grossman, L Massimo, DJ Irwin, CT McMillan, IM Nasrallah, C Toro, GK Aguirre, VM Van Deerlin, EB Lee : Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science 2020.

M Chen, J Nofziger, R Datta, JC Gee, J Morgan, GK Aguirre : The influence of axial length upon the retinal ganglion cell layer of the human eye. TVST 2020.

M Cieslak, ..., GK Aguirre, ..., TD Satterthwaite: QSIPrep: Robust workflows for preprocessing and reconstructing diffusion MRI. Nature Methods 2020.

Cooper RF, Aguirre GK, Morgan JIW: Fully Automated Estimation of Spacing and Density for Retinal Mosaics. Translational Vision Science & Technology 8(5), Oct 2019.

Kaiser EA, Igdalova A, Aguirre GK, Cucchiara B: A web-based, branching logic questionnaire for the automated classification of migraine. Cephalalgia 39(10): 1257-1266, Sep 2019.

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Last updated: 01/21/2021
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