faculty photo
Associate Professor of Medicine at the Veteran's Administration Medical Center
Department: Medicine

Contact information
3400 Civic Center Drive, PCAM 7S GI
Philadelphia, PA 19104
Office: 215-349-8222
Fax: 215-349-5915
Lab: 215-823-5800 x 6729
B.A. (Political Science)
University of California, San Diego, 1992.
University of Texas Southwestern Medical School, 1997.
M.Sc. (Patient-Oriented Research)
University of Pennsylvania, 2007.
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Description of Research Expertise

Hepatitis C and hepatocellular carcinoma immunopathogenesis

Description of Clinical Expertise

Hepatology, viral and non-viral chronic liver disease and cirrhosis, hepatocellular carcinoma, end-stage liver disease

Selected Publications

Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH; VOCAL Study Group.: Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 156(6): 1693-1706, Jan 2019.

Ioannou George N, Beste Lauren A, Green Pamela K, Singal Amit G, Tapper Elliot B, Waljee Akbar K, Sterling Richard K, Feld Jordan J, Kaplan David E, Taddei Tamar H, Berry Kristin: Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients with Baseline Cirrhosis or High FIB-4 Scores. Gastroenterology 157(5): 1264-1278.e4, Jul 2019.

Serper Marina, Weinberg Ethan M, Cohen Jordana B, Reese Peter P, Taddei Tamar H, Kaplan David E: Mortality and hepatic decompensation in patients with cirrhosis and atrial fibrillation treated with anticoagulation. Hepatology (Baltimore, Md.) epatology, Apr 2020.

Emdin Connor A, Haas Mary E, Khera Amit V, Aragam Krishna, Chaffin Mark, Klarin Derek, Hindy George, Jiang Lan, Wei Wei-Qi, Feng Qiping, Karjalainen Juha, Havulinna Aki, Kiiskinen Tuomo, Bick Alexander, Ardissino Diego, Wilson James G, Schunkert Heribert, McPherson Ruth, Watkins Hugh, Elosua Roberto, Bown Matthew J, Samani Nilesh J, Baber Usman, Erdmann Jeanette, Gupta Namrata, Danesh John, Saleheen Danish, Chang Kyong-Mi, Vujkovic Marijana, Voight Ben, Damrauer Scott, Lynch Julie, Kaplan David, Serper Marina, Tsao Philip, Mercader Josep, Hanis Craig, Daly Mark, Denny Joshua, Gabriel Stacey, Kathiresan Sekar: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS genetics 16(4): e1008629, Apr 2020.

Serper Marina, Kaplan David E, Shults Justine, Reese Peter P, Beste Lauren A, Taddei Tamar H, Werner Rachel M: Quality measures, all-cause mortality, and healthcare utilization in a national cohort of Veterans with cirrhosis. Hepatology (Baltimore, Md.) 70(6): 2062-2074, May 2019.

Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M : Background Progenitor Activation is Associated with Recurrence after Hepatectomy of Combined Hepatocellular Cholangiocarcinoma. Hepatology 56(5): 1804-16, Jun 2012 Notes: DOI: 10.1002/hep.25874.

Mahmud N, Fricker Z, Serper M, Kaplan DE, Rothstein KD, Goldberg DS.: In-Hospital mortality varies by procedure type among cirrhosis surgery admissions. Liver Int 39(8): 1394-1399, Aug 2019.

Serper M, Choi G, Forde-McLean K, Kaplan DE: Care Delivery and Outcomes among U.S. Veterans with Hepatitis B: A National Cohort Study. Hepatology 63(6): 1774-82, Jun 2016.

Kaplan DE, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Knott A, Pedrosa M, Pocha C, Mehta R, Duggal M, Skanderson M, Valderrama A, Taddei T: Development and performance of an algorithm to estimate the Child-Turcotte-Pugh Score from a national electronic healthcare database. Clin Gastro Hepatol 13(13): 2333-41 e1-6, Dec 2015.

Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM. : Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132(2): 654-666, February 2007.

Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, Reddy KR, Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41(6): 1365-75, June 2005.

Sugimoto K, Kaplan DE, Ikeda F, Ding J, Schwartz J, Nunes FA, Alter HJ, Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection. Journal of Virology 79(11): 6976-83, June 2005.

Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48(6): 903-913, June 2008.

Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134(7): 1927-37, 1937.e1-2, June 2008.

Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. Clinical Immunology 139(3): 302-313, June 2011 Notes: doi:10.1016/j.clim.2011.02.014.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study. Annals of Internal Medicine 155(6): 353-360, September 2011.

Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology 55(3): 709-719, March 2012.

Li Y, Siegel DL, Scholler N, Kaplan DE.: Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library. BMC Biotechnology 12(1): 23, May 2012.

Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C. Clin Trials 9(1): 102-112, Feb 2012.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R : Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients. AIDS Behav 17(1): 94-103, Jan 2013 Notes: doi: 10.1007/s10461-012-0288-9.

Darpolor MM, Kaplan DE, Pedersen PL, Glickson JD. : Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy. J Liver: Dis Transplant 1(1), August 2012 Notes: doi:http://dx.doi.org/10.4172/jldt.1000101.

Adeyemo O, Doi H, Reddy KR, Kaplan DE: Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection. Journal of Viral Hepatitis 20(7): 453-62, July 2013.

Kluck J, O'Flynn RM, Kaplan DE, Chang KM: Evaluation of the Significance of Pretreatment Liver Biopsy and Baseline Mental Health Disorder Diagnosis on Hepatitis C Treatment Completion Rates at a Veterans Affairs Medical Center. Hepatitis Research and Treatment 2013: 653976, May 2013 Notes: doi:10.1155/2013/653976.

Doi H, Tanoue S, Kaplan DE: Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis. Clinical Immunology 150(2): 184-191, February 2014.

Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA: Aspartate Metabolism Pathway is Differentiable in Human Hepatocellular Carcinoma: Transcriptomics and 13C-Isotope based Metabolomics. NMR Biomed 27(4): 381-9, Apr 2014.

Goldberg DS, French B, Forde KA, Groeneveld PW, Bitterman T, Backus L, Halpern SD, Kaplan DE: Association of distance from a transplant center with access to waitlist placement, receipt of liver transplantation, and survival. JAMA 311(12): 1234-43, Mar 2014.

Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, Chang KM: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J Clin Gastroenterol 49(4): e31-e40, Apr 2015.

Chang LY, Kaplan DE: Hepatitis C viremia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B-cells. The 67th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2016, Boston MA, Abstract #62 (Parallel Session 9, Oral presentation) Nov 2016.

Goldberg DS, Taddei TH, Serper M, Mehta R, Dieperink E, Aytaman A, Baytarian M, Fox R, Hunt K, Pedrosa M, Pocha C, Valderrama A, Kaplan DE: Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis. Hepatology 65(3): 864-874, Mar 2017 Notes: doi: 10.1002/hep.28765.

Chang LY, Li Y, Kaplan DE: Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis. Scientific Reports 6: 36862, Nov 2016 Notes: DOI: 10.1038/srep36862.

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Last updated: 02/12/2021
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