MacLean Nasrallah, MD PhD

faculty photo
Assistant Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Hospital of the University of Pennsylvania
FO6.089
3400 Spruce St.
Philadelphia, PA 19104
Education:
AB (Mathematics)
Harvard University, 1997.
PhD (Neuroscience)
University of Pennsylvania, 2010.
MD
University of Pennsylvania, 2012.
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Description of Clinical Expertise

neuropathology
molecular pathology of neuropathology

Description of Research Expertise

brain development
mouse models
in utero electroporation in mouse models
molecular biology

Selected Publications

Viaene AN, Santi M, Rosenbaum J, Li MM, Surrey LF, Nasrallah MP.: SETD2 mutations in primary central nervous system tumors. Acta Neuropathologica Communications November 2018.

Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder ZA, Lustig RA, O'Rourke DM, Brem S, Desai AS, Nasrallah MP.: Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma. Journal of Neurooncology November 2018.

Binder ZA, Thorne AH, Bakas S, Wileyto EP, Bilello M, Akbari H, Rathore S, Ha SM, Zhang L, Ferguson CJ, Dahiya S, Bi WL, Reardon DA, Idbaih A, Felsberg J, Hentschel B, Weller M, Bagley SJ, Morrissette JJD, Nasrallah MP, Ma J, Zanca C, Scott AM, Orellana L, Davatzikos C, Furnari FB, O'Rourke DM: Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer Cell July 2018.

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O'Rourke DM, Davatzikos C.: In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature. Neuro Oncol July 2018.

Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C: Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1. Scientific Reports March 2018.

O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV: A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med 9: 399, Jul 2017.

Zeh R, Sheikh S, Xia L, Pierce J, Newton A, Predina J, Cho S, Nasrallah M, Singhal S, Dorsey J, Lee JYK: The second window ICG technique demonstrates a broad plateau period for near infrared fluorescence tumor contrast in glioblastoma. PLoS One 12(7): e0182034, Jul 2017 Notes: doi: 10.1371/journal.pone.0182034. eCollection 2017.

Pierce JT, Cho SS, Nag S, Zeh R, Jeon J, Holt D, Durham A, Nasrallah MP, Singhal S, Lee JYK.: Folate Receptor Overexpression in Human and Canine Meningiomas-Immunohistochemistry and Case Report of Intraoperative Molecular Imaging. Neurosurgery August 2018.

Cho SS, Zeh R, Pierce JT, Jeon J, Nasrallah M, Adappa ND, Palmer JN, Newman JG, White C, Kharlip J, Snyder P, Low P, Singhal S, Grady MS, Lee JYK.: Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas. Oper Neurosurg April 2018.

Nabavizadeh SA, Pechersky D, Schmitt JE, Nasrallah M, Wolf R, Loevner L, Mamourian AC: Perilesional hyperintensity on T1-weighted images in intra-axial brain masses other than cavernous malformations. J Neuroimaging 5: 531-538, Sep 2017 Notes: First published: 18 January 2017. DOI: 10.1111/jon.12424.

Verma G, Mohan S, Nasrallah MP, Brem S, Lee JY, Chawla S, Wang S, Nagarajan R, Thomas MA, Poptani H: Non-invasive detection of 2-hydroxyglutarate in IDH-mutated gliomas using two-dimensional localized correlation spectroscopy (2D L-COSY) at 7 Tesla. J Transl Med 14(1): 274, Sep 2016.

Marsh ED, Nasrallah MP, Walsh C, Murray KA, Nicole Sunnen C, McCoy A, Golden JA: Developmental interneuron subtype deficits after targeted loss of Arx. BMC Neurosci 17(1): 35, Jun 2016.

Piazza MA, Ramayya AG, Geiger GA, Alonso-Basanta M, Nasrallah MP, Welch WC, Ozturk AK: Intramedullary recurrence of a thoracic meningioma-presentation of an unusual case and review of the literature. World Neurosurg 92: 588, Aug 2016 Notes: Case report and review.

Cho G, Nasrallah MP, Lim Y, Golden JA: Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations. Neurogenetics 13(1): 23-9, Feb 2012.

Nasrallah MP, Cho G, Simonet JC, Putt ME, Kitamura K, Golden JA: Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression. Hum Mol Genet 21(5): 1090-8, Mar 2012.

Nasrallah IM, McManus MF, Pancoast MM, Wynshaw-Boris A, Golden JA: Analysis of non-radial interneuron migration dynamics and its disruption in Lis1+/- mice. J Comp Neurol 496(6): 847-58, Jun 2006.

Pancoast M, Dobyns W, Golden JA: Interneuron deficits in patients with the Miller-Dieker syndrome. Acta Neuropathol 109(4): 400-4, Apr 2005 Notes: Comparative study; Published under Dr. MacLean Nasrallah's maiden name.

McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden JA: Lis1 is necessary for normal non-radial migration of inhibitory interneurons. Am J Pathol 165(3): 775-84, Sep 2004 Notes: Published under Dr. MacLean Nasrallah's maiden name.

Nasrallah MP, Nasrallah IM, Prelack MS, Johnson MO, Lewis TB, Rubenstein M, Minturn JE, Desai A, Marcotte P, Santi M, Martinez-Lage M: 19-year-old male with headaches and a possible seizure. Brain Pathol 27(4): 557-558, Jul 2017.

Wu J, Zou T, Bai HX, Li X, Zhang Z, Xiao B, Nasrallah M, Karakousis G, Cao Y, Zhang PJ, Yang L: Comparison of chemoradiotherapy with radiotherapy alone for "biopsy only" anaplastic astrocytoma Oncotarget 8(40): 69038-69046, Apr 2017 Notes: doi: 10.18632/oncotarget.17441. eCollection 2017 Sep 15.

Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, Ujhazi B, Csomos K, Bosticardo M, Dobbs K, Nasrallah M, Notarangelo LD, Holland SM, Fadugba O.: Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. Journal of Clinical Immunology August 2018.

Chawla S, Wang S, Mohan S, Nasrallah M, Verma G, Brem S, O'Rourke DM, Wolf RL, Poptani H, Nabavizadeh SA.: Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI. J Magn Reson Imaging April 2018.

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Last updated: 07/18/2019
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