Lillias H. Maguire, MD
Assistant Professor of Surgery
Active Surgeon, Pennsylvania Hospital, Philadelphia, PA
Active Surgeon, Penn Presbyterian Medical Center, Philadelphia, PA
Active Surgeon , Cpl. Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA
Attending Surgeon, Hospital of the University of Pennsylvania, Philadelphia, PA
Associate Program Director, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Department: Surgery
Contact information
Division of Colorectal Surgery
Hospital of the University of Pennsylvania
3400 Spruce Street, 4 Silverstein
Philadelphia, PA 19104
Hospital of the University of Pennsylvania
3400 Spruce Street, 4 Silverstein
Philadelphia, PA 19104
Office: 734-936-5738
Education:
BA (Biology)
Pomona College, Claremont, CA, 2004.
MD
University of Pennsylvania School of Medicine, Philadelphia, PA, 2008.
Permanent linkBA (Biology)
Pomona College, Claremont, CA, 2004.
MD
University of Pennsylvania School of Medicine, Philadelphia, PA, 2008.
Description of Clinical Expertise
Minimally invasive colorectal surgery, rectal cancer surgery, inflammatory bowel disease, robotic surgery, colonoscopy, anorectal surgeryDescription of Research Expertise
Translational genomics research in colorectal diseases, clinical trials, genome-wide association studies, surgical grantsmanship, diverticulitis, pilonidal diseaseSelected Publications
Brendan Moran MD, Lily Maguire MD, Sanjeev Dayal MD: Peritoneal Malignancies and Colorectal Peritoneal Metastases. Advances in Coloproctology - European Manual of Medicine, Third Edition. Springer, 2026 Notes: (accepted, pending).RC Acker, JL Roberson, JC McVey, E Kaufman, RR Kelz, JB Morris, MK Lee, LH Maguire: Grantsmanship Refined: Evaluation and Training of Efficacy in Residents (Greater Study). Journal of Surgical Education 2026.
Neylan CJ, Levin MG, Hartmann K, Beigel K, Khodursky S, DePaolo JS, Abramowitz S, Furth EE, Heuckeroth RO, Damrauer SM, Maguire LH: Genome-wide association meta-analysis identifies 126 novel loci for diverticular disease and implicates connective tissue and colonic motility. medRxiv Mar. 28 2025 (Preprint) Notes: doi: 10.1101/2025.03.27.25324777.
Ueland TE, Shelley JP, Mosley JD, Robinson JR, Gamazon ER, Maguire LH, Peek R, Hawkins AT: Plasma proteomic signatures for diverticulitis risk stratification. Journal of Surgical Research Aug. 23 2025 (Epub) Notes: doi: 10.1016/j.jss.2025.06.093.
Ma W, Ha J, Neylan CJ, Munro H, Skerrett D, Downie JM, Sevilla-González M, Steinwandel M, Mumma M, Zheng W, Maguire LH, Giovannucci EL, Strate LL, Chan AT: Lifestyle factors, genetic susceptibility and risk of incident diverticulitis: An integrated analysis of four prospective cohort studies and electronic health records-linked biobank. Gut July 1 2025 (Epub) Notes: doi: 10.1136/gutjnl-2025-335364.
Neylan CJ, Bercz A, Regenbogen SE, Huang EH, Smith JJ, Maguire LH, Mitchem JB: Appraising a CREATEive surgeon-scientist initiative: Impact and future directions. Diseases of the Colon & Rectum 68(6): 656-657, June 1 2025 Notes: Epub Mar. 4, 2025.
Neylan CJ, Ueland T, Abramowitz SA, DePaolo JS, Tsao NL, Roberson JL, Hawkins AT, Carey DJ, Smelser DT, Levin MG, Hoffman RL, Damrauer SM, Maguire LH.: Novel polygenic risk score associates with diverticulitis in a multi-institutional, ancestrally diverse cohort. Nature Scientific Reports 2025.
Roberson JL, Passman JE, Lee MK 4th, Singhal S, Kelz R, Morris JB, Maguire LH: Resident self-efficacy in grantsmanship lags behind key funding deadlines. Journal of Surgical Education 81(12): 103280, Dec. 2024 Notes: Epub Oct. 7, 2024.
Roberson JL, Neylan CJ, Judy R, Walker V, Tsao PS, Damrauer SM, Maguire LH: Critical genes in genitourinary embryogenesis are related to the development of adult hydrocele. Science Reports 14(1): 30314, Dec. 5 2024.
Ueland TE, Mosley J, Robinson JR, Peek R, Gamazon ER, Maguire LH, Neylan C, Hoffman R, Hawkins AT: Nature, nurture or both? Genetic risk, healthy lifestyle, and severe diverticulitis. Journal of the American College of Surgeons 239(5 Suppl 1): S94-S95, Nov. 2024 Notes: Presented at the Owen H. Wangensteen Scientific Forum of the 2024 American College of Surgeons Clinical Congress, San Francisco, CA, Oct. 2024.