Payal D. Shah, MD
Assistant Professor of Medicine (Hematology-Oncology) at the Hospital of the University of Pennsylvania
Attending , Hospital of the University of Pennsylvania
Deputy Lead, Breast Cancer Clinical Research Unit, University of Pennsylvania, Abramson Cancer Center
Department: Medicine
Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
10th Floor, South Pavilion
Office #10-152
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
10th Floor, South Pavilion
Office #10-152
Philadelphia, PA 19104
Office: 215-349-5730
Fax: 215-615-3349
Fax: 215-615-3349
Education:
BA (Bachelor of Arts in Biological Sciences, Magna Cum Laude)
Columbia College, Columbia University , 2004.
MD (Doctor of Medicine )
Perelman School of Medicine, University of Pennsylvania , 2009.
Permanent linkBA (Bachelor of Arts in Biological Sciences, Magna Cum Laude)
Columbia College, Columbia University , 2004.
MD (Doctor of Medicine )
Perelman School of Medicine, University of Pennsylvania , 2009.
Description of Other Expertise
Dr. Payal D. Shah is an Assistant Professor of Medicine at the University of Pennsylvania, where she serves as the Deputy Physician Lead of the Breast Cancer Clinical Trials Unit in the Abramson Cancer Center and as a clinical investigator in the Basser Center for BRCA. Dr. Shah completed her medical training in Internal Medicine at the Hospital of the University of Pennsylvania, followed by a Medical Oncology Fellowship at Memorial Sloan Kettering Cancer Center before joining the Penn Medicine faculty. She cares for patients with breast cancer as well as individuals with inherited cancer risk. Her areas of focus include triple-negative breast cancer, metaplastic breast cancer, and breast cancer associated with germline genetic pathogenic variants.Dr. Shah’s research centers on the development of novel therapies and understanding biomarkers of cancer response and resistance to treatment. She is a PI for several investigator-initiated and industry-sponsored clinical trials, with a portfolio that includes targeted therapy and immunotherapy, including novel agents such as PARP inhibitors and CAR T-cells. Her work has been supported by institutional and national funding, including an ASCO Conquer Cancer Foundation Young Investigator Award and a Susan G. Komen Career Catalyst Research Award.
Nationally, Dr. Shah serves on several committees including the National Comprehensive Cancer Network (NCCN) Breast Cancer Risk Reduction Panel, the ASCO Germline Mutation Testing in Breast Cancer Expert Panel, and the ASCO Scientific Program Committee.
Selected Publications
Qian F, Wang S, Mitchell J, McGuffog L, Barrowdale D, Leslie G, Oosterwijk JC, Chung WK, Evans DG, Engel C, Kast K, Aalfs CM, Adank MA, Adlard J, Agnarsson BA, Aittomäki K, Alducci E, Andrulis IL, Arun BK, Ausems MGEM, Azzollini J, Barouk-Simonet E, Barwell J, Belotti M, Benitez J, Berger A, Borg A, Bradbury AR, Brunet J, Buys SS, Caldes T, Caligo MA, Campbell I, Caputo SM, Chiquette J, Claes KBM, Margriet Collée J, Couch FJ, Coupier I, Daly MB, Davidson R, Diez O, Domchek SM, Donaldson A, Dorfling CM, Eeles R, Feliubadaló L, Foretova L, Fowler J, Friedman E, Frost D, Ganz PA, Garber J, Garcia-Barberan V, Glendon G, Godwin AK, Gómez Garcia EB, Gronwald J, Hahnen E, Hamann U, Henderson A, Hendricks CB, Hopper JL, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Izquierdo Á, Jakubowska A, Kaczmarek K, Kang E, Karlan BY, Kets CM, Kim SW, Kim Z, Kwong A, Laitman Y, Lasset C, Hyuk Lee M, Won Lee J, Lee J, Lester J, Lesueur F, Loud JT, Lubinski J, Mebirouk N, Meijers-Heijboer HEJ, Meindl A, Miller A, Montagna M, Mooij TM, Morrison PJ, Mouret-Fourme E, Nathanson KL, Neuhausen SL, Nevanlinna H, Niederacher D, Nielsen FC, Nussbaum RL, Offit K, Olah E, Ong KR, Ottini L, Park SK, Peterlongo P, Pfeiler G, Phelan CM, Poppe B, Pradhan N, Radice P, Ramus SJ, Rantala J, Robson M, Rodriguez GC, Schmutzler RK, Hutten Selkirk CG, Shah PD, Simard J, Singer CF, Sokolowska J, Stoppa-Lyonnet D, Sutter C, Yen Tan Y, Teixeira RM, Teo SH, Terry MB, Thomassen M, Tischkowitz M, Toland AE, Tucker KM, Tung N, van Asperen CJ, van Engelen K, van Rensburg EJ, Wang-Gohrke S, Wappenschmidt B, Weitzel JN, Yannoukakos D; GEMO Study Collaborators; HEBON; EMBRACE, Greene MH, Rookus MA, Easton DF, Chenevix-Trench G, Antoniou AC, Goldgar DE, Olopade OI, Rebbeck TR, Huo D: Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study. Journal of the National Cancer Institute 111(14): 350-364, Apr 2019.Demissei BG, Finkelman BS, Hubbard RA, Smith AM, Narayan HK, Narayan V, Shah P, Waxman AJ, Domchek SM, Ky B.: Cardiovascular Function Phenotypes in Response to Cardiotoxic Breast Cancer Therapy. Journal of the American College of Cardiology 73(2): 248-249, Jan 2019.
Demissei BG, Finkelman B, Hubbard RA, Zhang L, Smith AM, Sheline K, McDonald C, Narayan HK, Narayan V, Waxman AJ, Domchek SM, DeMichele A, Shah P, Clark AS, Bradbury A, Carver JR, Upshaw J, Armenian SH, Liu P, Ky B: Detailed phenotyping reveals distinct trajectories of cardiovascular function and symptoms with exposure to modern breast cancer therapy. Cancer 125(16): 2762-2771, Aug 2019.
McDonald ES, Carlin S, Maxwell KN, Nayak A, Doot RK, Pantel AR, Farewell MD, Pryma DA, Clark AS, Shah P, DeMichele A, Ziober A, Schubert EK, Palmer K, Lee HS, Matro J, Cruz L de la, Tchou J, Anderson DN, Feldman MD, Sheffer RE, Knollman H, Schnall MD, Makvandi M, Domchek S, Hubbard RA, Mach RH, Mankoff DA: Abstract PD4-07: PET imaging of PARP-1 expression in breast cancer. San Antonio Breast Cancer Symposium 2018, Cancer Research 79(4_Supplement): PD4-07, Feb 2019 Notes: Poster Presentation.
McKenna DB, Van Den Akker J, Zhou AY, Ryan L, Leon A, O'Connor R, Shah PD, Rustgi AK, Katona BW.: Identification of a novel GREM1 duplication in a patient with multiple colon polyps. Familial Cancer 18(1): 63-66, Jan 2019.
Rebbeck TR, Friebel TM, Friedman E, Hamann U, Huo D, Kwong A, Olah E, Olopade OI, Solano AR, Teo SH, Thomassen M, Weitzel JN, Chan TL, Couch FJ, Goldgar DE, Kruse TA, Palmero EI, Park SK, Torres D, van Rensburg EJ, McGuffog L, Parsons MT, Leslie G, Aalfs CM, Abugattas J, Adlard J, Agata S, Aittomäki K, Andrews L, Andrulis IL, Arason A, Arnold N, Arun BK, Asseryanis E, Auerbach L, Azzollini J, Balmaña J, Barile M, Barkardottir RB, Barrowdale D, Benitez J, Berger A, Berger R, Blanco AM, Blazer KR, Blok MJ, Bonadona V, Bonanni B, Bradbury AR, Brewer C, Buecher B, Buys SS, Caldes T, Caliebe A, Caligo MA, Campbell I, Caputo SM, Chiquette J, Chung WK, Claes KBM, Collée JM, Cook J, Davidson R, de la Hoya M, De Leeneer K, de Pauw A, Delnatte C, Diez O, Ding YC, Ditsch N, Domchek SM, Dorfling CM, Velazquez C, Dworniczak B, Eason J, Easton DF, Eeles R, Ehrencrona H, Ejlertsen B; EMBRACE, Engel C, Engert S, Evans DG, Faivre L, Feliubadaló L, Ferrer SF, Foretova L, Fowler J, Frost D, Galvão HCR, Ganz PA, Garber J, Gauthier-Villars M, Gehrig A; GEMO Study Collaborators, Gerdes AM, Gesta P, Giannini G, Giraud S, Glendon G, Godwin AK, Greene MH, Gronwald J, Gutierrez-Barrera A, Hahnen E, Hauke J; HEBON, Henderson A, Hentschel J, Hogervorst FBL, Honisch E, Imyanitov EN, Isaacs C, Izatt L, Izquierdo A, Jakubowska A, James P, Janavicius R, Jensen UB, John EM, Vijai J, Kaczmarek K, Karlan BY, Kast K, Investigators K, Kim SW, Konstantopoulou I, Korach J, Laitman Y, Lasa A, Lasset C, Lázaro C, Lee A, Lee MH, Lester J, Lesueur F, Liljegren A, Lindor NM, Longy M, Loud JT, Lu KH, Lubinski J, Machackova E, Manoukian S, Mari V, Martínez-Bouzas C, Matrai Z, Mebirouk N, Meijers-Heijboer HEJ, Meindl A, Mensenkamp AR, Mickys U, Miller A, Montagna M, Moysich KB, Mulligan AM, Musinsky J, Neuhausen SL, Nevanlinna H, Ngeow J, Nguyen HP, Niederacher D, Nielsen HR, Nielsen FC, Nussbaum RL, Offit K, Öfverholm A, Ong KR, Osorio A, Papi L, Papp J, Pasini B, Pedersen IS, Peixoto A, Peruga N, Peterlongo P, Pohl E, Pradhan N, Prajzendanc K, Prieur F, Pujol P, Radice P, Ramus SJ, Rantala J, Rashid MU, Rhiem K, Robson M, Rodriguez GC, Rogers MT, Rudaitis V, Schmidt AY, Schmutzler RK, Senter L, Shah PD, Sharma P, Side LE, Simard J, Singer CF, Skytte AB, Slavin TP, Snape K, Sobol H, Southey M, Steele L, Steinemann D, Sukiennicki G, Sutter C, Szabo CI, Tan YY, Teixeira MR, Terry MB, Teulé A, Thomas A, Thull DL, Tischkowitz M, Tognazzo S, Toland AE, Topka S, Trainer AH, Tung N, van Asperen CJ, van der Hout AH, van der Kolk LE, van der Luijt RB, Van Heetvelde M, Varesco L, Varon-Mateeva R, Vega A, Villarreal-Garza C, von Wachenfeldt A, Walker L, Wang-Gohrke S, Wappenschmidt B, Weber BHF, Yannoukakos D, Yoon SY, Zanzottera C, Zidan J, Zorn KK, Hutten Selkirk CG, Hulick PJ, Chenevix-Trench G, Spurdle AB, Antoniou AC, Nathanson KL.: Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. Human Mutation 39(5): 593-620, May 2018.
Shah PD, Nathanson KL: Application of Panel-Based Tests for Inherited Risk of Cancer. Annual Review of Genomics and Human Genetics. 18: 201-227, August 2017.
D Finkelman BS, Putt M, Wang T, Wang L, Narayan H, Domchek SM, DeMichele A, Fox KR, Matro J, Shah P, Clark AS, Bradbury AR, Narayan V, Carver J, Wilson Tang WH, Ky B.: Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer. Journal of the American College of Cardiology 70(2): 152-162, July 2017.