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Rong Zhou, PhD
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Research Professor of Radiology
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Member, Institute of Regenerative Medicine, University of Pennsylvania
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Member, Institute of Translational Medicine and Therapeutics (ITMAT) , University of Pennsylvania
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Full Member of the Abramson Cancer Center, Abramson Cancer Center of the University of Pennsylvania
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Member of Department Committee on Appointments and Promotions (DCOAP) , University of Pennsylvania
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Department: Radiology
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Graduate Group Affiliations
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- Bioengineering e
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Contact information
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198 John Morgan Building
35 3620 Hamilton Walk
Philadelphia, PA 19104
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35 3620 Hamilton Walk
Philadelphia, PA 19104
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Office: (215)-746-8747
32 Fax: 215-573-2113
34 Lab: (215)-746-8752
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32 Fax: 215-573-2113
34 Lab: (215)-746-8752
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Email:
rongzhou@upenn.edu
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rongzhou@upenn.edu
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Publications
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Links
df Search PubMed for articles
f9 Rong Zhou is leading a NIH/NCI funded resource program "Penn Quantitative Imaging Resource for Pancreatic Cancer" and the link is the resource website.
fc Rong Zhou Laboratory website
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df Search PubMed for articles
f9 Rong Zhou is leading a NIH/NCI funded resource program "Penn Quantitative Imaging Resource for Pancreatic Cancer" and the link is the resource website.
fc Rong Zhou Laboratory website
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Education:
21 7 BS 23 (Biomedical Engineering) c
36 Shanghai Jiao Tong University, 1987.
21 8 PhD 2b (Biophysics /Magnetic Resonance) c
40 State University of New York at Buffalo, 1998.
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Permanent link21 7 BS 23 (Biomedical Engineering) c
36 Shanghai Jiao Tong University, 1987.
21 8 PhD 2b (Biophysics /Magnetic Resonance) c
40 State University of New York at Buffalo, 1998.
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68 Developing imaging markers (MRI/S and PET) of metabolic signatures of cancer and heart failure.
4f Developing in vivo imaging markers for assessing therapeutic responses.
24 Stem cells and cardiac repair
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Description of Research Expertise
48 Magnetic resonance imaging (MRI) and spectroscopy (MRS)68 Developing imaging markers (MRI/S and PET) of metabolic signatures of cancer and heart failure.
4f Developing in vivo imaging markers for assessing therapeutic responses.
24 Stem cells and cardiac repair
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144 Zhou R*, Pantel AR, Li S, Lieberman BP, Ploessl K, Choi H, Blankemeyer E, Lee H, Kung HF, Mach RH, Mankoff DA*: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Research 2 4f 77(6): 1476-1484, March 2017 Notes: *Corresponding author.
3f Vishwanath, Krithik c Choi, Hoon e Gupta, Mamta c Zhou, Rong 11 Sorace, Anna G. 16 Yankeelov, Thomas E. e1 Lima, Ernesto A. B. F.: Modeling tumor dynamics and predicting response to therapies in a murine pancreatic cancer model. npj Systems Biology and Applications. Nature, 11(1): 123, November 2025.
16b Choi H, Gupta M, Sengupta A, Furth EE, Hensley C, Weljie AM, Lee H, Lu Y-T, Pantel A, Mankoff D, Zhou R*.: Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export. Neoplasia 61: 101136, 2025 Notes: *Corresponding author.
83 Cao J, Pickup S, Clendenin C, Blouw B, Choi H, Kang D, Rosen MA, O'Dwyer PJ and Zhou R* f5 : Dynamic contrast-enhanced MRI detects responses to stroma-directed therapy in mouse models of pancreatic ductal adenocarcinoma. Clinical Cancer Research 25(7): 2314-2322, April 2019 Notes: * corresponding author.
187 Zhou R*, Bagga P, Nath K, Hariharan H, Mankoff DA and Reddy R*: Glutamate-weighted Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple Negative Breast Cancer. Cancer Research 78(19): 5521-5526, August 2018 Notes: * corresponding author.
149 Zhou R*, Bansal N, Leeper DB, Glickson JD : Intracellular acidification of human melanoma xenografts by respiratory inhibitor meta-iodobenzylguanidine plus hyperglycemia: a 31P magnetic resonance spectroscopy study. Cancer Research 60(13): 3532-3536, 2000.
12d Choi H, Liu T, Nath K, Zhou R* and Chen IW*: Peptide nanoparticle with pH-sensing cargo solubility enhances cancer drug efficiency. Nano Today 13: 15-22, March 2017 Notes: * Corresponding authors. Nano Today Impact Factor = 17.
113 Liu T, Choi H, Zhou R* and Chen I*: RES Blockade: A Strategy for Boosting Efficiency of Nanoparticle Drug. Nano Today 10(1): 11-21, Feb 2015 Notes: *Corresponding author. Nano Today Impact Factor = 17.
e0 Zhou R*, Acton PD, Ferrari VA: Imaging Stem Cells Implanted in Infarcted Myocardium. Journal of American College of Cardiology 48(10): 2094-2106, 2006.
174 Zhang H, Qiao H, Frank RS, Huang B, Propert KJ, Margulies S, Ferrari VA, Epstein JA, Zhou R*. : Spin-Labeling Magnetic Resonance Imaging Detects Increased Myocardial Blood Flow After Endothelial Cell Transplantation in the Infarcted Heart. Circulation: Cardiovascular Imaging. 5(2): 210-217, 2012.
182 Qiao H, Zhang H, Yamanaka S, Patel VV, Petrenko NB, Huang B, Muenz LR, Ferrari VA, Boheler KR and Zhou R*: Long-term Improvement in Post-Infarct Left Ventricular Global and Regional Contractile Function Mediated by Embryonic Stem Cell-Derived Cardiomyocytes. Circulation: Cardiovascular Imaging 4(1): 33-41, 2011.
14e Qiao H, Zhang H, Zheng Y, Ponde DE, Shen D, Gao F, Bakken A, Schmitz A, Kung HF, Ferrari VA, and Zhou R*: Embryonic Stem Cell Grafting in Normal and Infarcted Myocardium: Serial Assessment with MR Imaging and PET Dual Detection. Radiology 250(3): 821-829, 2009.
116 Zhou R, Idiyatullin D, Moeller S, Corum C, Zhang H, Qiao H, Zhong J, Garwood M : SWIFT Detection of SPIO Labeled Stem Cells Grafted in the Myocardium. Magnetic Resonance in Medicine 63(5): 1154-1161, 2010.
11a Zhou R, Thomas DT, Qiao H, Bal H, Choi SR, Alavi A, Ferrari VA, Kung HF and Acton PD.: In vivo Detection of Stem Cells Grafted in the Infarcted Rat Myocardium. Journal of Nuclear Medicine 46(5): 816-822, 2005.
150 Zhou R*, Pickup S, Yankeelov T, Springer Jr. CS, Glickson JD : Simultaneous measurement of AIF and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange. Magnetic Resonance in Medicine 52(2): 248-257, 2004.
120 Zhou R*, Steve Pickup, Jerry Glickson, Craig Scott and Victor Ferrari : Assessment of Global and Regional Myocardial Function in the Mouse Using Cine and Tagged MRI. Magnetic Resonance in Medicine 49: 760-764, 2003.
18d Lowell AN, Qiao H, Liu T, Ishikawa T, Zhang H, Oriana S, Wang M, Ricciotti E, FitzGerald GA, Zhou R* and Yamakoshi Y* : Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images. Bioconjugate Chemistry 23(11): 2313-2319, 2012 Notes: *Corresponding author.
16e Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, and Epstein JA: Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. Journal of Clinical Investigation 112: 863-871, 2003.
15d Abtahian F, Guerriero A, Lu M, Zhou R, Mocsai A, Myers E, Huang B, Jackson D, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, and Kahn M: Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299(5604): 247-251, 2003.
144 Auricchio A, Zhou R, Wilson J, Glickson J: In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene. Proceeding of National Academy of Science (USA) 98(9): 5205-5210, 2001.
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Selected Publications
1ae Mamta Gupta, Hoon Choi, Samantha B Kemp, Emma E Furth, Stephen Pickup, Cynthia Clendenin, Margo Orlen, Mark Rosen, Fang Liu, Quy Cao, Ben Z Stanger, Rong Zhou*: Multimetric MRI Captures Early Response and Acquired Resistance of Pancreatic Cancer to KRAS Inhibitor Therapy. Clinical Cancer Research 31(13): 2663-2674, April 2025 Notes: *Corresponding author.144 Zhou R*, Pantel AR, Li S, Lieberman BP, Ploessl K, Choi H, Blankemeyer E, Lee H, Kung HF, Mach RH, Mankoff DA*: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Research 2 4f 77(6): 1476-1484, March 2017 Notes: *Corresponding author.
3f Vishwanath, Krithik c Choi, Hoon e Gupta, Mamta c Zhou, Rong 11 Sorace, Anna G. 16 Yankeelov, Thomas E. e1 Lima, Ernesto A. B. F.: Modeling tumor dynamics and predicting response to therapies in a murine pancreatic cancer model. npj Systems Biology and Applications. Nature, 11(1): 123, November 2025.
16b Choi H, Gupta M, Sengupta A, Furth EE, Hensley C, Weljie AM, Lee H, Lu Y-T, Pantel A, Mankoff D, Zhou R*.: Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export. Neoplasia 61: 101136, 2025 Notes: *Corresponding author.
83 Cao J, Pickup S, Clendenin C, Blouw B, Choi H, Kang D, Rosen MA, O'Dwyer PJ and Zhou R* f5 : Dynamic contrast-enhanced MRI detects responses to stroma-directed therapy in mouse models of pancreatic ductal adenocarcinoma. Clinical Cancer Research 25(7): 2314-2322, April 2019 Notes: * corresponding author.
187 Zhou R*, Bagga P, Nath K, Hariharan H, Mankoff DA and Reddy R*: Glutamate-weighted Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple Negative Breast Cancer. Cancer Research 78(19): 5521-5526, August 2018 Notes: * corresponding author.
149 Zhou R*, Bansal N, Leeper DB, Glickson JD : Intracellular acidification of human melanoma xenografts by respiratory inhibitor meta-iodobenzylguanidine plus hyperglycemia: a 31P magnetic resonance spectroscopy study. Cancer Research 60(13): 3532-3536, 2000.
12d Choi H, Liu T, Nath K, Zhou R* and Chen IW*: Peptide nanoparticle with pH-sensing cargo solubility enhances cancer drug efficiency. Nano Today 13: 15-22, March 2017 Notes: * Corresponding authors. Nano Today Impact Factor = 17.
113 Liu T, Choi H, Zhou R* and Chen I*: RES Blockade: A Strategy for Boosting Efficiency of Nanoparticle Drug. Nano Today 10(1): 11-21, Feb 2015 Notes: *Corresponding author. Nano Today Impact Factor = 17.
e0 Zhou R*, Acton PD, Ferrari VA: Imaging Stem Cells Implanted in Infarcted Myocardium. Journal of American College of Cardiology 48(10): 2094-2106, 2006.
174 Zhang H, Qiao H, Frank RS, Huang B, Propert KJ, Margulies S, Ferrari VA, Epstein JA, Zhou R*. : Spin-Labeling Magnetic Resonance Imaging Detects Increased Myocardial Blood Flow After Endothelial Cell Transplantation in the Infarcted Heart. Circulation: Cardiovascular Imaging. 5(2): 210-217, 2012.
182 Qiao H, Zhang H, Yamanaka S, Patel VV, Petrenko NB, Huang B, Muenz LR, Ferrari VA, Boheler KR and Zhou R*: Long-term Improvement in Post-Infarct Left Ventricular Global and Regional Contractile Function Mediated by Embryonic Stem Cell-Derived Cardiomyocytes. Circulation: Cardiovascular Imaging 4(1): 33-41, 2011.
14e Qiao H, Zhang H, Zheng Y, Ponde DE, Shen D, Gao F, Bakken A, Schmitz A, Kung HF, Ferrari VA, and Zhou R*: Embryonic Stem Cell Grafting in Normal and Infarcted Myocardium: Serial Assessment with MR Imaging and PET Dual Detection. Radiology 250(3): 821-829, 2009.
116 Zhou R, Idiyatullin D, Moeller S, Corum C, Zhang H, Qiao H, Zhong J, Garwood M : SWIFT Detection of SPIO Labeled Stem Cells Grafted in the Myocardium. Magnetic Resonance in Medicine 63(5): 1154-1161, 2010.
11a Zhou R, Thomas DT, Qiao H, Bal H, Choi SR, Alavi A, Ferrari VA, Kung HF and Acton PD.: In vivo Detection of Stem Cells Grafted in the Infarcted Rat Myocardium. Journal of Nuclear Medicine 46(5): 816-822, 2005.
150 Zhou R*, Pickup S, Yankeelov T, Springer Jr. CS, Glickson JD : Simultaneous measurement of AIF and tumor pharmacokinetics in mice by dynamic contrast enhanced imaging: effects of transcytolemmal water exchange. Magnetic Resonance in Medicine 52(2): 248-257, 2004.
120 Zhou R*, Steve Pickup, Jerry Glickson, Craig Scott and Victor Ferrari : Assessment of Global and Regional Myocardial Function in the Mouse Using Cine and Tagged MRI. Magnetic Resonance in Medicine 49: 760-764, 2003.
18d Lowell AN, Qiao H, Liu T, Ishikawa T, Zhang H, Oriana S, Wang M, Ricciotti E, FitzGerald GA, Zhou R* and Yamakoshi Y* : Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images. Bioconjugate Chemistry 23(11): 2313-2319, 2012 Notes: *Corresponding author.
16e Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, and Epstein JA: Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. Journal of Clinical Investigation 112: 863-871, 2003.
15d Abtahian F, Guerriero A, Lu M, Zhou R, Mocsai A, Myers E, Huang B, Jackson D, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, and Kahn M: Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299(5604): 247-251, 2003.
144 Auricchio A, Zhou R, Wilson J, Glickson J: In vivo detection of gene expression in liver by 31P nuclear magnetic resonance spectroscopy employing creatine kinase as a marker gene. Proceeding of National Academy of Science (USA) 98(9): 5205-5210, 2001.
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