John Nicholas Lukens, M.D.

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-662-6567
BA ((Distinction in History))
Yale University, 1999.
University of Pennsylvania School of Medicine, 2008.
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Description of Clinical Expertise

My clinical expertise is in the treatment of head and neck cancers and gastrointestinal cancers. Additionally, I have specialized training in brachytherapy, which consists of placing radioactive sources within, or directly adjacent to a tumor, as a means of delivering highly targeted radiation. I have experience in head and neck, prostate, and gastrointestinal brachytherapy, as well as intra-operative radiotherapy. I have a particular clinical interest in the re-treatment of patients who have undergone a prior course of radiation, through the integration of highly targeted techniques such as proton therapy and brachytherapy. I believe strongly in the importance of an interdisciplinary approach, and work closely with my surgical and medical oncology colleagues to optimize patient outcomes.

Description of Research Expertise

My research focuses on the multidisciplinary management of head and neck cancers, in particular novel strategies to understand and mitigate the toxicities associated with head and neck radiotherapy. Additionally, I am interested in identifying subsets of patients with HPV+ cancer who may benefit from treatment de-intensification, and conversely, those with high-risk disease who may benefit from novel targeted therapy and/or immunotherapy.

Selected Publications

Butala AA, Jain V, Reddy VK, Sebro RA, Song Y, Karakousis G, Mitchell TC, Lukens JN, Shabason JE: Impact of Tumor-Infiltrating Lymphocytes on Overall Survival in Merkel Cell Carcinoma. Oncologist September 2020.

Michael T. Werner, Ryan M. Carey, W. Greer Albergotti, John N. Lukens, Robert M. Brody: Impact of the COVID-19 Pandemic on the Management of Head and Neck Malignancies. Otolaryngology-Head and Neck Surgery April 2020 Notes: Epub ahead of print.

Alyssa M. Civantos, Ryan M. Carey, Gary R. Lichtenstein, John N. Lukens, Roger B. Cohen, Christopher H. Rassekh: Care of Immunocompromised Patients with Head and Neck Cancer During the COVID-19 Pandemic: Two Challenging and Informative Clinical Cases. Head & Neck April 2020 Notes: Epub ahead of print.

Jahan J. Mohiuddin1, Brian Chu, Andrea Facciabene, Kendra Poirier, Xingmei Wang, Abigail Doucette, Cathy Zheng, Wei Xu, Emily J. Anstadt, Ravi K. Amaravadi, Giorgos C. Karakousis, Tara C. Mitchell, Alexander C. Huang, Jacob E. Shabason, Alexander Lin, Samuel Swisher-McClure, Amit Maity, Lynn M. Schuchter, John N. Lukens: Association of antibiotic exposure with survival and toxicity in patients with melanoma receiving immunotherapy. Journal of the National Cancer Institute April 2020 Notes: Epub ahead of print.

Hague Christina, Aznar Marianne, Dong Lei, Fotouhi-Ghiam Alireza, Lee Lip Wai, Li Taoran, Lin Alexander, Lowe Matthew, Lukens John N, McPartlin Andrew, O'Reilly Shannon, Slevin Nick, Swisher-Mcclure Samuel, Thomson David, Van Herk Marcel, West Catharine, Zou Wei, Teo Boon-Keng Kevin: Inter-fraction robustness of intensity-modulated proton therapy in the post-operative treatment of oropharyngeal and oral cavity squamous cell carcinomas. The British journal of radiology 93(1107): 20190638, Mar 2020.

Yun Song, James Sun, Richard J. Straker, Adrienne B. Shannon, Leah S. Cohen, Elnara Muradova, Hala Daou, Vernon K. Sondak, Evan J. Wuthrick, Jonathan S. Zager, Alexander Lin, J. Nicholas Lukens*, Giorgos C. Karakousis* *Contributed equally to this study as senior authors. : Adjuvant radiation therapy for clinical stage III melanoma in the modern therapeutic era. Society of Surgical Oncology International Conference March 2020.

Grewal Amardeep S, Rajasekaran Karthik, Cannady Steven B, Chalian Ara A, Ghiam Alireza F, Lin Alexander, LiVolsi Virginia, Lukens John N, Mitra Nandita, Montone Kathleen T, Newman Jason G, O'Malley Bert W, Rassekh Christopher H, Weinstein Gregory S, Swisher-McClure Samuel: Pharyngeal-sparing radiation for head and neck carcinoma of unknown primary following TORS assisted work-up. The Laryngoscope 130(3): 691-697, Mar 2020.

Swisher-McClure Samuel, Lukens John N, Aggarwal Charu, Ahn Peter, Basu Devraj, Bauml Joshua M, Brody Robert, Chalian Ara, Cohen Roger B, Fotouhi-Ghiam Alireza, Geiger Geoffrey, Gershowitz Jared, Livolsi Virginia, Mitra Nandita, Montone Kathleen, Newman Jason, Ojerholm Eric, O'Malley Bert, Rajasekaran Karthik, Tan Erik, Weinstein Gregory, Lin Alexander: A Phase 2 Trial of Alternative Volumes of Oropharyngeal Irradiation for De-intensification (AVOID): Omission of the Resected Primary Tumor Bed After Transoral Robotic Surgery for Human Papilloma Virus-Related Squamous Cell Carcinoma of the Oropharynx. International journal of radiation oncology, biology, physics 106(4): 725-732, Mar 2020.

Jain Varsha, Hwang Wei-Ting, Venigalla Sriram, Nead Kevin T, Lukens John N, Mitchell Tara C, Shabason Jacob E: Association of Age with Efficacy of Immunotherapy in Metastatic Melanoma. The oncologist 25(2): e381-e385, Feb 2020.

Jain Varsha, Venigalla Sriram, Reddy Vishruth K, Lukens John N, Mitchell Tara C, Shabason Jacob E: Association of Insurance Status With Presentation, Treatment, and Survival in Melanoma in the Era of Immune Checkpoint Inhibitors. Journal of immunotherapy (Hagerstown, Md. : 1997) 43(1): 8-15, Jan 2020.

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Last updated: 11/11/2020
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