Karl Degenhardt, MD, PhD

faculty photo
Penn Medicine Clinician of Pediatrics
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Cardiology, Abramson RM 416E
34th & Civic Center Boulevard
Philadelphia, PA 19104-4399
Office: 215-590-1791
Fax: 215-590-5454
BA (Biology, magna cum laude)
Washington University, St. Louis, MO, 1990.
Mount Sinai School of Medicine, New York, NY, 2000.
Mount Sinai School of Medicine, New York, NY, 2001.
--- (Completed first 2 years of medical school and 1 1/2 yrs of graduate school prior to going to NY)
Boston University School of Medicine, Boston, MA, 2001.
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Selected Publications

Aghajanian H, Cho YK, Rizen NW, Wang Q, Li L, Degenhardt K, Jain R: Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and development of the great arteries. Dis Model Mech Jul 2017.

Degenhardt K, Rychik J: Fetal Situs, Isomerism, Heterotaxy Syndrome: Diagnostic Evaluation and Implication for Postnatal Management. Curr Treat Options Cardiovasc Med 18(12): 77, Dec 2016 Notes: [PubMed - in process]

Aghajanian H, Cho YK, Manderfield LJ, Herling MR, Gupta M, Ho VC, Li L, Degenhardt K, Aharonov A, Tzahor E, Epstein JA: Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor. Nat Commun 30(7): 12038, Jun 2016.

Saul D, Degenhardt K, Iyoob S, Johnson A, Surrey L, Johnson M, Rychik J, Victoria T: Hypoplastic Left Heart Syndrome and the Nutmeg Lung Pattern in Utero: A Cause and Effect Relationship or Prognostic Indicator? Pediatr Radiol 46(4): 483-9, Apr 2016 Notes: Accepted. Notes: *Co-first author with equal contribution

Huang Y, Degenhardt K, Astrof S, Zhou C: Imaging of Murine Embryonic Cardiovascular Development using Optical Coherence Tomography. SPIE Photonics West 2016 San Francisco, CA Jan 2016.

Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S: Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Dev Biol 407(2): 195-210, Nov 2015.

Saul D, Degenhardt K, Iyoob S, Johnson A, Johnson M, Rychik J, Victoria T: Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: A cause and effect relationship or prognostic indicator? Society for Pediatric Radiology Annual Meeting & Postgraduate Course 2015, Bellevue, WA Nov 2015.

Jay PY, Degenhardt K, Anderson, RH, Atrial Septal Defects – Molecular Pathways and Animal Models (Chapter 21) in Rickert-Sperling S, Kelly R, Driscoll D (Eds.) : Congenital Heart Diseases: The Broken Heart. Springer 2015 Notes: ISBN 978-3-7091-1882-5.

Liang D, Wang X, Mittal A, Dhiman S, Hou SY, Degenhardt K, Astrof S: Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis. Dev Biol 395(2): 232-44, Nov 2014.

Channing A, Szwast A, Natarajan S, Degenhardt K, Tian Z, Rychik J: Maternal Hyperoxygenation improves left heart filling in the fetus with atrial septal aneurysm causing impediment to left ventricular inflow. Ultrasound Obstet Gynecol 45(6): 630, Jun 2014.

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Last updated: 11/24/2020
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