Karl Degenhardt, MD, PhD

faculty photo
Clinical Associate Professor of Pediatrics (Cardiology)
Penn Medicine Clinician, Division of Cardiology, Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Cardiology, Abramson RM 416E
34th & Civic Center Boulevard
Philadelphia, PA 19104-4399
Office: 215-590-1791
Fax: 215-590-5454
BA (Biology, magna cum laude)
Washington University, St. Louis, MO, 1990.
Mount Sinai School of Medicine, New York, NY, 2000.
Mount Sinai School of Medicine, New York, NY, 2001.
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Selected Publications

Barrera CA, Johnson AM, Rychik J, Biko DM, Degenhardt K, Moldenhauer J, Victoria T: Prognostic value of the nutmeg lung pattern/lymphangiectasia on fetal magnetic resonance imaging. Pediatric Radiology 51(4): doi: 10.1007, April 2021.

McPherson E, Korlesky C, Hebbring S: Congenital heart disease in monochorionic twins with and without twin-to-twin transfusion syndrome. Clin Med Res 18(2-3): 58-67, August 2020.

Aghajanian H, Cho YK, Rizen NW, Wang Q, Li L, Degenhardt K, Jain R: Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and development of the great arteries. Dis Model Mech 10(9): 1101-1108, Jul 2017.

Degenhardt K, Rychik J: Fetal Situs, Isomerism, Heterotaxy Syndrome: Diagnostic Evaluation and Implication for Postnatal Management. Curr Treat Options Cardiovasc Med 18(12): 77, Dec 2016.

Aghajanian H, Cho YK, Manderfield LJ, Herling MR, Gupta M, Ho VC, Li L, Degenhardt K, Aharonov A, Tzahor E, Epstein JA: Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor. Nat Commun 30(7): 12038, Jun 2016.

Saul D, Degenhardt K, Iyoob S, Johnson A, Surrey L, Johnson M, Rychik J, Victoria T: Hypoplastic Left Heart Syndrome and the Nutmeg Lung Pattern in Utero: A Cause and Effect Relationship or Prognostic Indicator? Pediatr Radiol 46(4): 483-9, Apr 2016 Notes: Accepted. Notes: *Co-first author with equal contribution

Huang Y, Degenhardt K, Astrof S, Zhou C: Imaging of Murine Embryonic Cardiovascular Development using Optical Coherence Tomography. SPIE Photonics West 2016 San Francisco, CA Jan 2016.

Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S: Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Dev Biol 407(2): 195-210, Nov 2015.

Saul D, Degenhardt K, Iyoob S, Johnson A, Johnson M, Rychik J, Victoria T: Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: A cause and effect relationship or prognostic indicator? Society for Pediatric Radiology Annual Meeting & Postgraduate Course 2015, Bellevue, WA Nov 2015.

Jay PY, Degenhardt K, Anderson, RH, Atrial Septal Defects – Molecular Pathways and Animal Models (Chapter 21) in Rickert-Sperling S, Kelly R, Driscoll D (Eds.) : Congenital Heart Diseases: The Broken Heart. Springer 2015 Notes: ISBN 978-3-7091-1882-5.

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Last updated: 07/20/2021
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