Erica L. Carpenter, MBA, PhD

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
#8-104
South Pavilion, 8th Floor
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-746-4427
Education:
BS (Business/Mathematics)
Oregon State University, 1984.
MBA (Business)
Dartmouth College, 1989.
PhD (Immunology)
University of Pennsylvania, 2009.
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Description of Research Expertise

The Circulating Tumor Material (CTM) Center, led by Director Dr. Erica Carpenter, focuses on the identification, capture, and analysis of Circulating Tumor Cells (CTCs) and cell-free DNA (cfDNA) from cancer patients. Blood, bone marrow, pleural effusions, and other non-invasively captured patient samples are used to detect biomarkers which allow: 1) early detection of disease as well as post-therapy monitoring of minimal residual disease, 2) an efficient means of determining clinical and biological response to therapy and, thus, clinical decision making, and, 3) cancer genetic phenotyping to drive personalized medicine that obviates the need for serial biopsies in a population of patients for which these procedures are difficult, risky, and insufficient. The focus of the CTM Center is driven by the needs of clinicians and translational investigators, and realized through collaborative work with investigators in the Penn School of Medicine, the Penn School of Engineering, and the Center for Personalized Diagnostics. Moreover, when it is determined that outsourcing of technology development is preferable, collaborative efforts with industry partners are actively sought, and these efforts have already been initiated in focused areas.

Selected Publications

Kim Anna Reiss, Rosemarie Mick, Mark H. O'Hara, Ursina R. Teitelbaum, Thomas Benjamin Karasic, Charles John Schneider, Peter J. O'Dwyer, Danielle Karlson, Stacy Cowden, Mary Jane Fuhrer, Erica Carpenter, Austin A Pantel, Mehran Makvandi, David A. Mankoff, Katharine Nathanson, Kara Noelle Maxwell, Gregory Lawrence Beatty, Susan M. Domchek: A Randomized Phase II Trial of Niraparib Plus Either Nivolumab or Ipilimumab in Patients With Advanced Pancreatic Cancer Whose Cancer Has Not Progressed on Platinum-Based Therapy American Society of Clinical Oncologists General Meeting May 2019.

Mark H. O’Hara, Eileen O’Reilly, Rosemarie Mick, Gauri Varadhachary, Zev Wainberg, Andrew Ko, George Fisher, Osama Rahma, Jaclyn P. Lyman, Christopher R. Cabanski, Erica L. Carpenter, Travis Hollmann, Pier F. Gherardini, Lacey Kitch, Cheryl Selinsky, Theresa LaVallee, Ovid C. Trifan, Ute Dugan, Vanessa Lucey, Robert H. Vonderheide: A Phase 1b Study of CD40 Agonistic Monoclonal Antibody APX005M Together with Gemcitabine (Gem) and nab-Paclitaxel (NP) with or without Nivolumab (Nivo) in Untreated Metastatic Ductal Pancreatic Adenocarcinoma (PDAC) Patients American Association of Cancer Research General Meeting April 2019.

Bardia Yousefi, Nariman Jahani, Michael J. LaRiviere, Eric Cohen, Meng-Kang Hsieh,José Marcio Luna, Rhea D. Chitalia, Jeffrey C. Thompson, Erica L. Carpenter,Sharyn I. Katz, Despina Kontos: Correlative Hierarchical Clustering-based Low-Rank dimensionality reduction of radiomics-driven phenotype in Non-Small Cell Lung Cancer. SPIE Medical Imaging 2019 February 2019.

Ling Wang, Lynn Godfrey, Maria Krevvata, Keely Dulmage, Cathy Spargo, Liping Yu, Silin Sa, Frances Tong, Erica Carpenter, Alfred Garfall, and Eric Dixon: Applying novel technologies to develop a sensitive liquid biopsy for transcriptomic single-cell profiling of circulating multiple myeloma cells. AGBT General Meeting February 2019.

Vivek Narayan, Whitney Gladney, Gabriela Plesa, Neha Vapiwala, Erica Carpenter, Shannon L. Maude, Priti Lal, Simon F. Lacey, Jan Joseph Melenhorst, Ronnie Sebro, Michael Farwell, Wei-Ting Hwang, Michael Moniak, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, Christina Marie Coughlin, Carl H. June, Naomi B. Haas: A Phase 1 Clinical Trial of PSMA-directed/TGFβ-insensitive CAR-T cells in Metastatic Castration-Resistant Prostate Cancer. American Society of Clinical Oncologists Genitourinary Cancers Symposium February 2019.

Jeffrey C. Thompsona*, Ryan Fanb, Taylor Blackb, Gordon H. Yuc, Samantha L. Savitchb, Austin Chienb, Stephanie S. Yeeb, Moen Senb, Wei-Ting Hwangd,f, Sharyn I. Katze,f, Michael Feldmanc,f, Anil Vachania,f, Erica L. Carpenterb,f,: Measurement and Immunophenotyping of Pleural Fluid EpCAM-Positive Cells and Clusters for the Management of Non-Small Cell Lung Cancer Patients Lung Cancer Lung Cancer January 2019.

Kim Anna Reiss, Edgar Ben-Josef, Nevena Damjanov, Maarouf Hoteit, Thomas Benjamin Karasic, Erica Carpenter, Lisa DiCicco, Luis Anna Garcia-Marcano, Rosemarie Mick, Robert H Vonderheide: A Pilot Study of Galunisertib (LY2157299) Plus Stereotactic Body Radiotherapy (SBRT) in Advanced Hepatocellular Carcinoma (HCC). American Society of Clinical Oncologists Gastrointestinal Cancers Symposium January 2019.

Mark H. O’Hara, Eileen O’Reilly,*, Rosemarie Mick, Gauri Varadhachary, Zev Wainberg, Andrew Ko, George Fisher, Osama Rahma, Erica L. Carpenter,Jaclyn P. Lyman, Christopher R. Cabanski, Ovid C. Trifan, Ute Dugan, Vanessa Lucey, Robert H. Vonderheide: A Phase 1b Study of CD40 Agonistic Monoclonal Antibody APX005M Together with Gemcitabine and nab-Paclitaxel with or without Nivolumab in Untreated Metastatic Ductal Pancreatic Adenocarcinoma (PDAC) Patients American Society for Clinical Oncology Gastrointestinal Cancers Symposium January 2019.

Charu Aggarwal, Christiana W. Davis, Rosemarie Mick, and Jeffrey C. Thompson, Saman Ahmed, Seth Jeffries, Stephen Bagley, Peter Gabriel, Tracey L. Evans, Joshua M. Bauml, Christine Ciunci, Evan Alley, Jennifer J.D. Morrissette, Roger B. Cohen, Erica L. Carpenter, and Corey J. Langer: Influence of TP53 Mutation on Survival in Patients With Advanced EGFR-Mutant Non–Small-Cell Lung Cancer. Journal of Clinical Oncology, Precision Medicine January 2019.

Jae W. Lee, Meredith L. Stone, Paige M. Porrett, Stacy K. Thomas, Chad A. Komar, Joey H. Li, Devora Delman, Kathleen Graham, Whitney L. Gladney, Xia Hua, Taylor A. Black, Austin L. Chien, Krishna S. Majmundar, Jeffrey C. Thompson, Stephanie S. Yee, Mark O’Hara, Charu Aggarwal1, Dong Xin, Abraham Shaked, Mingming Gao, Dexi Liu, Mitesh J. Borad, Ramesh K. Ramanathan, Erica L. Carpenter, Ailing Ji, Maria C. de Beer, Frederick C. de Beer, Nancy R. Webb, & Gregory L. Beatty: Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature in press 2019.

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Last updated: 03/02/2019
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