Erica L. Carpenter, MBA, PhD
South Pavilion, 8th Floor
3400 Civic Center Blvd
Philadelphia, PA 19104
Oregon State University, 1984.
Dartmouth College, 1989.
University of Pennsylvania, 2009.
Description of Research ExpertiseThe Circulating Tumor Material (CTM) Center, led by Director Dr. Erica Carpenter, focuses on the identification, capture, and analysis of Circulating Tumor Cells (CTCs) and cell-free DNA (cfDNA) from cancer patients. Blood, bone marrow, pleural effusions, and other non-invasively captured patient samples are used to detect biomarkers which allow: 1) early detection of disease as well as post-therapy monitoring of minimal residual disease, 2) an efficient means of determining clinical and biological response to therapy and, thus, clinical decision making, and, 3) cancer genetic phenotyping to drive personalized medicine that obviates the need for serial biopsies in a population of patients for which these procedures are difficult, risky, and insufficient. The focus of the CTM Center is driven by the needs of clinicians and translational investigators, and realized through collaborative work with investigators in the Penn School of Medicine, the Penn School of Engineering, and the Center for Personalized Diagnostics. Moreover, when it is determined that outsourcing of technology development is preferable, collaborative efforts with industry partners are actively sought, and these efforts have already been initiated in focused areas.
Selected PublicationsMoen Sen, Keely Dulmage, Sindhushree Raghunandan, Charles H. Pletcher Jr, Ling Wang, William J. Murphy, Tommi Rantapero, Wenping Sun, Stephanie S. Yee, Jeffrey C. Thompson, Jonni S. Moore, Eric P. Dixon, Erica L. Carpenter: Isolation and molecular characterization of rare tumor derived single cells from the pleural effusion of lung cancer patients using a novel flow-cytometry based platform. International Society for Advancement of Cytometry, Cyto 2020 June 2020 Notes: Meeting cancelled due to pandemic.
Shen H, Lin A, Carpenter EL, Stanger B, Issadore DA: Extracellular Vesicle Biomarkers for Non-Small Cell Lung Cancer Early Diagnosis and Immunotherapy Response Prediction. International Society of Extracellular Vesicles Annual Meeting May 2020 Notes: Meeting cancelled due to pandemic.
Vivek Narayan, Whitney Gladney, Gabriela Plesa, Neha Vapiwala, Erica L. Carpenter, Shannon L. Maude, Priti Lal, Simon F. Lacey, Jan J. Melenhorst, Joseph Fraietta, Ronnie Sebro, Michael Farwell, Michael Moniak, Joan Gilmore, Lester Lledo, Karen Dengel, Amy Marshall, Christina Marie Coughlin, Carl H. June, Naomi B. Haas: A Phase 1 Clinical Trial of PSMA-directed/TGFβ-insensitive CAR-T cells in Metastatic Castration-Resistant Prostate Cancer. American Society of Clinical Oncology, Genitourinary Cancers Symposium February 2020.
Zijian Yang, Michael J. LaRiviere, Jina Ko, Jacob E. Till, Theresa E. Christensen, Stephanie S. Yee, Taylor A. Black, Kyle Tien, Andrew Lin, Hanfei Shen, Neha Bhagwat, Daniel Herman, Andrew Adallah, Mark H. O’Hara, Charles M. Vollmer, Bryson W. Katona, Ben Z. Stanger, David Issadore, and Erica L. Carpenter: A multi-analyte, liquid biopsy approach for diagnosing and staging of pancreatic adenocarcinoma Clinical Cancer Research in press 2020.
Jeffrey H. Lin, Austin P. Huffman, Max M. Wattenberg, David M. Walter, Erica L. Carpenter, David M. Feldser, Gregory L. Beatty, Emma E. Furth, Robert H. Vonderheide: Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis. Journal of Experimental Medicine in press 2020.
C. Aggarwal, MD, MPH J. C. Thompson, MD, MTR A. L. Chien, BA K. J. Quinn, PhD W. Hwang, PhD T. A. Black, BA S. S. Yee, MS T. E. Christensen, BA M. J. LaRiviere, MD B. A. Silva K. C. Banks, MBA, MS R. J. Nagy, MS E. Helman, PhD A. T. Berman, MD, MSCE C. A. Ciunci, MD, MSCE A. P. Singh, MD J. S. Wasser, MD J. M. Bauml, MD C. J. Langer, MD R. B. Cohen, MD E. L. Carpenter, MBA, PhD: Baseline plasma tumor mutation burden predicts response to pembrolizumab-based therapy in patients with metastatic non-small cell lung cancer. Clinical Cancer Research in press 2020.
S. Ali Nabavizadeh, Jeffrey B. Ware, Samantha Guiry, MacLean P. Nasrallah, Jazmine J. Mays, Jacob E. Till, Jasmin Hussain, Aseel Abdalla, Stephanie S. Yee, Zev A. Binder, Donald M. O’Rourke , Steven Brem, Arati S. Desai, Ronald Wolf, Erica L. Carpenter and Stephen J. Bagley: Imaging and histopathologic correlates of plasma cell-free DNA concentration and circulating tumor DNA in adult patients with newly diagnosed glioblastoma. Neuro-Oncology Advances in press 2020.
Michael J. LaRiviere, MD, Bardia Yousefi, PhD, Austin L. Chien, BA, José Marcio Luna PhD, Sharyn I.Katz, MD, MTR, Michelle Hershman, MD, Leonid Roshkovan, MD, Maya Galperin-Aizenberg, MD, Charu Aggarwal MD, MPH, Erica L. Carpenter PhD, MBA, Despina Kontos PhD,, Jeffrey C. Thompson MD, MTR: Radiomic phenotypes associated with non-small cell lung cancer EGFR mutational profile and therapy response to EGFR inhibitors. Radiological Society of North America December 2019.
Bardia Yousefi, PhD, Michael LaRiviere, MD, Leonid Roshkovan, MD, Michelle Hershman, MD, Austin L. Chien, BA, Yogesh Gupta, DO, Maya Galperin-Aizenberg, MD, José Marcio Luna, PhD, Jeffrey C. Thompson MD, MTR, Charu Aggarwal PhD, MPH, Erica L. Carpenter MBA, PhD, Despina Kontos PhD, Sharyn I. Katz MD, MTR: Radiomic biomarker-predicted response to combination chemo-immunotherapy for non-small cell lung cancer. Radiological Society of North America December 2019.
L Roshkovan; B Yousefi; M J LaRiviere, MD; M L Hershman, MD; M Galperin-Aizenberg, MD; J M Luna Castaneda, J Thompson, MD; C Aggarwal, MD; E Carpenter, PhD; D Kontos, PhD; Sharyn Katz, MD: Impact of intravenous contrast enhancement on predictive radiomic features in patients with NSCLC treated with proton therapy.Impact of intravenous contrast enhancement on predictive radiomic features in patients with lung cancer. Radiological Society of North America Annual Meeting December 2019.