Erica L. Carpenter, MBA, PhD

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
#8-104
South Pavilion, 8th Floor
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-746-4427
Education:
BS (Business/Mathematics)
Oregon State University, 1984.
MBA (Business)
Dartmouth College, 1989.
PhD (Immunology)
University of Pennsylvania, 2009.
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Description of Research Expertise

The Circulating Tumor Material (CTM) Center, led by Director Dr. Erica Carpenter, focuses on the identification, capture, and analysis of Circulating Tumor Cells (CTCs) and cell-free DNA (cfDNA) from cancer patients. Blood, bone marrow, pleural effusions, and other non-invasively captured patient samples are used to detect biomarkers which allow: 1) early detection of disease as well as post-therapy monitoring of minimal residual disease, 2) an efficient means of determining clinical and biological response to therapy and, thus, clinical decision making, and, 3) cancer genetic phenotyping to drive personalized medicine that obviates the need for serial biopsies in a population of patients for which these procedures are difficult, risky, and insufficient. The focus of the CTM Center is driven by the needs of clinicians and translational investigators, and realized through collaborative work with investigators in the Penn School of Medicine, the Penn School of Engineering, and the Center for Personalized Diagnostics. Moreover, when it is determined that outsourcing of technology development is preferable, collaborative efforts with industry partners are actively sought, and these efforts have already been initiated in focused areas.

Selected Publications

Michael J. LaRiviere, MD, Bardia Yousefi, PhD, Austin L. Chien, BA, José Marcio Luna PhD, Sharyn I.Katz, MD, MTR, Michelle Hershman, MD, Leonid Roshkovan, MD, Maya Galperin-Aizenberg, MD, Charu Aggarwal MD, MPH, Erica L. Carpenter PhD, MBA, Despina Kontos PhD,, Jeffrey C. Thompson MD, MTR: Radiomic phenotypes associated with non-small cell lung cancer EGFR mutational profile and therapy response to EGFR inhibitors. Radiological Society of North America December 2019.

Bardia Yousefi, PhD, Michael LaRiviere, MD, Leonid Roshkovan, MD, Michelle Hershman, MD, Austin L. Chien, BA, Yogesh Gupta, DO, Maya Galperin-Aizenberg, MD, José Marcio Luna, PhD, Jeffrey C. Thompson MD, MTR, Charu Aggarwal PhD, MPH, Erica L. Carpenter MBA, PhD, Despina Kontos PhD, Sharyn I. Katz MD, MTR: Radiomic biomarker-predicted response to combination chemo-immunotherapy for non-small cell lung cancer. Radiological Society of North America December 2019.

L Roshkovan; B Yousefi; M J LaRiviere, MD; M L Hershman, MD; M Galperin-Aizenberg, MD; J M Luna Castaneda, J Thompson, MD; C Aggarwal, MD; E Carpenter, PhD; D Kontos, PhD; Sharyn Katz, MD: Impact of intravenous contrast enhancement on predictive radiomic features in patients with NSCLC treated with proton therapy.Impact of intravenous contrast enhancement on predictive radiomic features in patients with lung cancer. Radiological Society of North America Annual Meeting December 2019.

Michelle Hershman, MD, Bardia Yousefi, PhD, Maya Galperin-Aizenberg, MD, Leonid Roshkovan, MD, José Marcio Luna, PhD, Jeffrey C. Thompson MD, Michael LaRiviere, MD, Charu Aggarwal PhD, MPH, Erica L. Carpenter MBA, PhD, ,Sharyn I. Katz MD, MTR, Despina Kontos PhD: Impact of interobserver variability in manual segmentation of non-small cell lung cancer (NSCLC) on computed tomography. Radiological Society of North America December 2019.

B Yousefi; M J LaRiviere, MD; A Chien; J M Luna Castaneda; S I Katz, MD; M L Hershman; Roshkovan L; Galperin-Aizenberg M, Aggarwal C; Carpenter E; Kontos D; Thompson J : Radiomic phenotypes associated with non-small cell lung cancer EGFR mutational profile and therapy response to EGFR inhibitors. Pendergrass Symposium, Perelman School of Medicine at the University of Pennsylvania June 2019.

Charu Aggarwal1, Jeffrey C Thompson1, Austin Chien1, Katie Quinn2, Martina Lefterova2, Rebecca Nagy2, Stephanie Yee1, Christine A. Ciunci1, Evan W. Alley1, Joshua M. Bauml1, Roger B. Cohen1, Corey J. Langer1, Erica L. Carpenter1 : Dynamic monitoring of circulating tumor DNA next-generation gene sequencing as a predictive biomarker of response and progression free survival after pembrolizumab monotherapy in patients with advanced NSCLC American Society of Clinical Oncologists, General Meeting June 2019.

M J LaRiviere; B Yousefi; L Roshkovan; M L Hershman; A Chien; Y S Gupta, M Galperin-Aizenberg, J L Castaneda; C Aggarwal; E L Carpenter; D Kontos; J Thompson; S Katz: Radiomic biomarker-predicted response to combination chemo-immunotherapy for non-small cell lung cancer. Pendergrass Symposium, Perelman School of Medicine at the University of Pennsylvania June 2019.

Kim Anna Reiss, Rosemarie Mick, Mark H. O'Hara, Ursina R. Teitelbaum, Thomas Benjamin Karasic, Charles John Schneider, Peter J. O'Dwyer, Danielle Karlson, Stacy Cowden, Mary Jane Fuhrer, Erica Carpenter, Austin A Pantel, Mehran Makvandi, David A. Mankoff, Katharine Nathanson, Kara Noelle Maxwell, Gregory Lawrence Beatty, Susan M. Domchek: A Randomized Phase II Trial of Niraparib Plus Either Nivolumab or Ipilimumab in Patients With Advanced Pancreatic Cancer Whose Cancer Has Not Progressed on Platinum-Based Therapy American Society of Clinical Oncologists General Meeting May 2019.

Mark H. O’Hara, Eileen O’Reilly, Rosemarie Mick, Gauri Varadhachary, Zev Wainberg, Andrew Ko, George Fisher, Osama Rahma, Jaclyn P. Lyman, Christopher R. Cabanski, Erica L. Carpenter, Travis Hollmann, Pier F. Gherardini, Lacey Kitch, Cheryl Selinsky, Theresa LaVallee, Ovid C. Trifan, Ute Dugan, Vanessa Lucey, Robert H. Vonderheide: A Phase 1b Study of CD40 Agonistic Monoclonal Antibody APX005M Together with Gemcitabine (Gem) and nab-Paclitaxel (NP) with or without Nivolumab (Nivo) in Untreated Metastatic Ductal Pancreatic Adenocarcinoma (PDAC) Patients American Association of Cancer Research General Meeting April 2019.

Bardia Yousefi, Nariman Jahani, Michael J. LaRiviere, Eric Cohen, Meng-Kang Hsieh,José Marcio Luna, Rhea D. Chitalia, Jeffrey C. Thompson, Erica L. Carpenter,Sharyn I. Katz, Despina Kontos: Correlative Hierarchical Clustering-based Low-Rank dimensionality reduction of radiomics-driven phenotype in Non-Small Cell Lung Cancer. SPIE Medical Imaging 2019 February 2019.

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Last updated: 06/26/2019
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