Erica L. Carpenter, MBA, PhD

faculty photo
Research Assistant Professor of Medicine
Department: Medicine

Contact information
South Pavilion, 8th Floor
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-746-4427
BS (Business/Mathematics)
Oregon State University, 1984.
MBA (Business)
Dartmouth College, 1989.
PhD (Immunology)
University of Pennsylvania, 2009.
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Description of Research Expertise

The Circulating Tumor Material (CTM) Center, led by Director Dr. Erica Carpenter, focuses on the identification, capture, and analysis of Circulating Tumor Cells (CTCs) and cell-free DNA (cfDNA) from cancer patients. Blood, bone marrow, pleural effusions, and other non-invasively captured patient samples are used to detect biomarkers which allow: 1) early detection of disease as well as post-therapy monitoring of minimal residual disease, 2) an efficient means of determining clinical and biological response to therapy and, thus, clinical decision making, and, 3) cancer genetic phenotyping to drive personalized medicine that obviates the need for serial biopsies in a population of patients for which these procedures are difficult, risky, and insufficient. The focus of the CTM Center is driven by the needs of clinicians and translational investigators, and realized through collaborative work with investigators in the Penn School of Medicine, the Penn School of Engineering, and the Center for Personalized Diagnostics. Moreover, when it is determined that outsourcing of technology development is preferable, collaborative efforts with industry partners are actively sought, and these efforts have already been initiated in focused areas.

Selected Publications

Danielle Soucier-Ernst MPH MBE4, Candace Clark BS4, Natalie Shih MBChB MPH5, S. William Stavropoulos MD6,8, Kara N. Maxwell MD PhD1, Michael D. Feldman MD PhD5, David Lieberman MS CGC5, Jennifer J.D. Morrissette PhD5, Matt R. Paul BS3, Tien-chi Pan MS3, Jianping Wang3, Kevin R. Fox MD1,2,4,6, Jennifer M. Matro MD1,2,4,6, Amy S. Clark MD MSCE1,2,4,6, Payal D. Shah MD1,2,4,6, Susan M. Domchek MD1,2,4,6, Angela M. Bradbury MD1,2,4,6,7, Stephanie S. Yee1, Erica L. Carpenter MBA PhD1,6, Lewis A. Chodosh MD PhD1,3,6, Angela M. DeMichele MD MSCE1,2,4,6 : METAMORPH: METAstatic markers of recurrent tumor phenotype for breast cancer. AACR/San Antonio Breast Cancer Conference December 2017.

Maxwell Kara N, Soucier-Ernst Danielle, Tahirovic Emin, Troxel Andrea B, Clark Candace, Feldman Michael, Colameco Christopher, Kakrecha Bijal, Langer Melissa, Lieberman David, Morrissette Jennifer J D, Paul Matt R, Pan Tien-Chi, Yee Stephanie, Shih Natalie, Carpenter Erica, Chodosh Lewis A, DeMichele Angela: Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer. Breast cancer research and treatment 164(3): 627-638, Aug 2017.

Jina Ko, Neha Bhagwat, Stephanie S Yee, Taylor Black, Colleen Redlinger, Janae Romeo, Mark O’Hara, Arjun Raj, Erica L Carpenter, Ben Z Stanger, David Issadore: A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis. Lab on a Chip Aug 15 2017 Notes: In Press, doi: 10.1039/c7lc00703e.

Melina Marmarelis, MD; Jeffrey C. Thompson, MD; Charu Aggarwal, MD MPH; Tracey L. Evans, MD; Erica Carpenter, MBA PhD; Roger B. Cohen, MD; Corey J. Langer, MD; Joshua Bauml, MD: Emerging uses of Circulating Tumor DNA in advanced stage Non-Small Cell Lung Cancer. Annals of Translational Medicine July 2017 Notes: In press.

Kim A. Reiss, MD; Kara Maxwell, MD, PhD; Katharine Nathanson, MD; Ursina Teitelbaum, MD; Mark O’Hara, MD; Peter O’Dwyer, MD; Charles Schneider, MD; Erica Carpenter, PhD; Rosemarie Mick, MS, Susan Domchek, MD: A Single Arm Phase II Study of Rucaparib Maintenance in Patients with Advanced Pancreatic Adenocarcinoma and a Known Deleterious BRCA1, BRCA2 or PALB2 Mutation Who Have Achieved Stability on Platinum Therapy. American Society of Clinical Oncology - GI 2017.

Neha Bhagwat and Erica L. Carpenter: Flow cytometric methods for circulating tumor cell isolation and molecular analysis. Advances in Experimental Medicine and Biology 994: 105-118, 2017 Notes: 10.1007/978-3-319-55947-6_5

Stephanie S. Yee and Erica L. Carpenter: Enumeration, dielectrophoretic capture, and molecular analysis of circulating tumor cells. Methods in Molecular Biology 1634: 193-202, 2017.

Tara C. Gangadhar, Samantha L. Savitch, Stephanie S. Yee, Wei Xu, Alexander C. Huang, Shannon Harmon, David B. Lieberman, Devon Soucier, Ryan Fan, Jennifer J. D. Morrissette, Neeraj Salathia, Jill Waters, Shile Zhang, Jonathan Toung, Paul van Hummelen, Jian-Bing Fan, Xiaowei Xu, Ravi K. Amaravadi, Lynn M. Schuchter, Giorgos C. Karakousis, Wei-Ting Hwang, Erica L. Carpenter: Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma. Pigment Cell & Melanoma Research in press 2017.

Ko, Jina; Bhagwat, Neha; Yee, Stephanie; Ortiz, Natalia; Sahmoud, Amine; Black, Taylor; Aiello, Nicole; McKenzie, Lydie; O'Hara, Mark; Redlinger, Colleen; Romeo, Janae; Carpenter, Erica; Stanger, Ben; Issadore, David: Combining Machine Learning and Nanofluidic Technology to Diagnose Pancreatic Cancer Using Exosomes. ACS Nano in press 2017.

Thompson JC, Yee SS, Troxel AB, Savitch SL, Fan R, Balli D, Lieberman DB, Morrissette JD, Evans TL, Bauml J, Aggarwal C, Kosteva JA, Alley E, Ciunci C, Cohen RB, Bagley S, Stonehouse-Lee S, Sherry VE, Gilbert E, Langer C, Vachani A, Carpenter EL: Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA. Clinical Cancer Research 22(23): 5772-5782, Dec 1 2016.

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Last updated: 01/15/2018
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