Yongping Wang, MD, PhD
Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Cell Based Therapy Lab
Department of Pathology and Laboratory Medicine
5NW60 Main Building
Children's Hospital of Philadelphia
3401 Civic Center Blvd
Philadelphia, PA 19104
Department of Pathology and Laboratory Medicine
5NW60 Main Building
Children's Hospital of Philadelphia
3401 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759
Lab: 215-590-2807
Lab: 215-590-2807
Email:
wangy2@chop.edu
wangy2@chop.edu
Education
B.S. (Molecular Biophysics and Biochemistry; Economics)
Yale University, 1995.
M.D, Ph.D. (Medicine; Pharmacology)
Dartmouth Medical School, 2003.
Permanent linkB.S. (Molecular Biophysics and Biochemistry; Economics)
Yale University, 1995.
M.D, Ph.D. (Medicine; Pharmacology)
Dartmouth Medical School, 2003.
Description of Clinical Expertise
cGMP cellular therapy, stem cell, bone marrow transplant, hemoglobinopathy gene therapy, chimeric antigen receptor T cells (CARTs)Description of Research Expertise
RNAi, library screening, stem cell, erythropoiesisSelected Publications
Sarah Cotteta, Omar Banda, Yongping Wang, Mohamad-Gabriel Alameh, Stephan Grupp, Eugene Khandros, Stephan Kadauke: Ex Vivo HSC Base Editing Using LNP-Delivered ABE8e for Fetal Hemoglobin Induction in Sickle Cell Disease. International Society for Cell and Gene Therapy annual meeting, Dublin, Ireland May 2026.Allison Barz Leahy, Jennifer Brogdon, Lucy E. Cain, Amanda DiNofia, Joseph A. Fraietta, Nicholas Giacobbe, Richard Hanna, Kathleen Kane, Yimei Li, Shannon Maude, Regina Myers, Ezra Porter, Anna Sparrow, Nancy Shapiro, Melissa Varghese, Yongping Wang, Stephan Kadauke, Stephan A. Grupp: Scalable, Cost-Effective Point-of-Care Manufacture of huCART19 Cells with Excellent Clinical Outcomes in Pediatric B-ALL. International Society for Cell and Gene Therapy annual meeting, Dublin, Ireland May 2026.
Stephan A Grupp, Michael S Grimley, Timothy Driscoll, Kris Michael Mahadeo, Alexis Leonard, Yongping Wang, Helen Phillips, David Justus, Leslie E Lehmann, Erica Esrick, Sarah Nikiforow, Julie Kanter, Matthew Hsieh, John F Tisdale, Akshay Sharma, Zachary D Crees, John Manis : Improved Hematopoietic Stem Cell Mobilization for Gene Therapy of Hemoglobinopathies Using Single Agent Motixafortide. Transplantation and Cellular Therapy 32(2S): S18, Feb 2026.
Mitchell S. Cairo, Dean A Dean Lee, Laura Vella, Yanling Liao, Edo Schaefer, Allyson Flower, Yimei Li, Morgan Anderson-Crannage, Carmella van de Ven, Lauren Harrison, Erin Morris, Yongping Wang, Monica Manglani, Yi Qi, Jonathan Tedesco, Shalini Shenoy, Christopher C. Dvorak, Kenneth R. Cooke, Michael R. Verneris, Neena Kapoor, Julie A Talano: Genomic and Immunomic Characterization, Safety and Efficacy of Related Donor-Derived Cytotoxic T-Lymphocytes (CTLs) in Immunocompromised Recipients with Medically Refractory Adv and CMV Infection: On Behalf of the Viral CTL Consortium (VIRCTLC). Transplantation and Cellular Therapy 32(2S): S93, Feb 2026.
Wang Y, McKenna D, Spitzer T, Brunker P, Nedelcu E, Fesnak A, Celluzzi C, DiGuardo M, Jacob EK: Training in Cell and Gene Therapy Manufacturing: Unmet Needs and Arguments for Graduate Medical Education. Transfusion 66(1): 259-65, Jan 2026.
Caitlin W. Elgarten, Joseph H. Oved, Lisa Wray, Kimberly Venella, Peter Nicholas, Stephan Kadauke, Yongping Wang, Stephan Grupp, Timothy S. Olson: Alternative Donor Peripheral Stem Cell Transplantation With TCRαβ/CD19 Depletion For Pediatric Patients With Bone Marrow Failure. EJC Paediatric Oncology 6(Supplement 1), Dec 2025.
Sarah Cotteta, Omar Banda, Friederike Herbst-Nowrouzi, Brooklyn McDonald, Yongping Wang, Mohamad-Gabriel Alameh, Frederic Bushman, Stephan Grupp, Eugene Khandros, Stephan Kadauke: Toward ‘n of one’ gene therapies: Scalable ex vivo adenine base editing via lipid nanoparticles in a sickle cell disease model. Blood 146(Supplement 1), Nov 2025.
Gibson NM, Elgarten CW, Oved JH, Wray L, Freedman J, Khandros E, Worster E, Nicholas P, Kadauke S, Wang Y, Grupp S, Kwiatkowski JL, Olson TS: Outcomes of Unrelated Donor Stem Cell Transplantation with Partial T Cell Depletion for Pediatric Patients with Hemoglobinopathies. Transplant Cell Ther 31(10): 828.e1-e14, Oct 2025.
Mitchell S. Cairo, Julie-An Talano, Allyson Flower, Edo Schaefer, Yongping Wang, Yimei Li, Janet Ayello, Lauren Harrison, Yaya Chu, Yanling Liao, Kenneth Cooke, Michael Verneris, Julie Chu, Christopher Dvorak, Shalini Shenoy, Scott Goebel, Neena Kapoor, Rolla Abu-Anja, Caitlin Elgarten, Angelina Jacob, Laura Vella, Nancy Bunin, and Dean Lee: Final results of the safety and efficacy of related donor-derived CMV and Adenovirus (ADV) Cytotoxic T-Lymphocytes in children and adolescents with medically refractory infection. 57th Congress of the International Society of Paediatric Oncology, Amsterdam, Netherlands Oct 2025.
Nora M. Gibson, Arwa Z. Al-Riyami, Alexis Peedin, Stephan Kadauke, Stephan Grupp, Timothy S. Olson, Yongping Wang: Challenging immunophenotyping of patients with sickle cell disease adversely affects gene therapy product manufacturing – case reports. International Society for Cell and Gene Therapy Annual Meeting, New Orleans, LA May 2025.