Yongping Wang, MD, PhD
Associate Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Cell and Gene Therapy Lab
Department of Pathology and Laboratory Medicine
5NW60 Main Building
Children's Hospital of Philadelphia
3401 Civic Center Blvd
Philadelphia, PA 19104
Department of Pathology and Laboratory Medicine
5NW60 Main Building
Children's Hospital of Philadelphia
3401 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-590-4759
Lab: 215-590-2807
Lab: 215-590-2807
Email:
wangy2@chop.edu
wangy2@chop.edu
Education:
B.S. (Molecular Biophysics and Biochemistry; Economics)
Yale, 1995.
M.D, Ph.D. (Medicine; Pharmacology)
Dartmouth Medical School, 2003.
Permanent linkB.S. (Molecular Biophysics and Biochemistry; Economics)
Yale, 1995.
M.D, Ph.D. (Medicine; Pharmacology)
Dartmouth Medical School, 2003.
Description of Clinical Expertise
cGMP cellular therapy, stem cell, bone marrow transplant, mesenchymal stromal cell (MSC), chimeric antigen receptor T cells (CARTs)Description of Research Expertise
RNAi, library screening, stem cell, erythropoiesisSelected Publications
Arwa Z. Al-Riyami, Elena Maryamchik, Richard S. Hanna, Amir Reza Pashmineh Azar, Xingwu Zheng, Shilpa Choudhari, Colleen Finn, Nicholas Giacobbe, Rene Machietto, Robert Rieser, Farzaneh Ghasemi Tahrir, Xiaoyong Zhang, Stephan Kadauke, Yongping Wang: A Machine Learning Model That Incorporates CD45 Surface Expression Predicts Hematopoietic Progenitor Cell Recovery After Freeze-thaw. Cytotherapy 25(10): 1048-1056, Oct 2023.Rene Machietto, Nicholas Giacobbe, Jessica Perazzelli, Ted J. Hofmann, Allison Barz Leahy, Stephan A. Grupp, Yongping Wang, Stephan Kadauke: Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor. J Vis Exp 198: doi: 10.3791/65488 online only, Aug 2023.
Laura Breda, Tyler E. Papp, Michael P. Triebwasser, Amir Yadegari, Megan T. Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A. Grupp, Stella Chou, Houping Ni, Barbara L. Mui, Ying K. Tam, Drew Weissman, Stefano Rivella and Hamideh Parhiz: In vivo modification of hematopoietic stem cells by targeted lipid nanoparticles delivering mRNA. Science 381(6656): 436-443, Jul 2023.
Yaya Chu, Jordan Milner, Margaret Lamb, Elena Maryamchik, Olivia Rigot, Janet Ayello, Lauren Harrison, Rosemarie Shaw, Gregory K. Behbehani6, Elaine R. Mardis, Katherine Miller, Lakshmi Prakruthi Rao Venkata, Hsiaochi Chang, Dean Lee, Elana Rosenthal, Stephan Kadauke, Nancy Bunin, Julie-An Talano, Bryon Johnson, Yongping Wang*, and Mitchell S. Cairo* (*co-senior author): Manufacture and Characterization of GMP-Compliant SARS-COV-2 Cytotoxic T Lymphocytes. The Journal of Infectious Diseases 227(6): 788-799, Mar 2023.
Emily Roth, Danielle Reahm, Anna D'Aprile, Jason L Freedman, Stephan A. Grupp, and Yongping Wang: Infusing Collaboration: Stem Cell Infusion Day Procedures. American Society of Transplantation & Cellular Therapy annual meeting. Orlando, FL. Feb 2023.
Jordan Milner, Julie-An Talano, Lauren Harrison, Janet Ayello, Allyson Flower, Yaya Chu, Olivia Rigot, Bryon D Johnson, Yimei Li, Dean Anthony Lee, Rolla Abu-Arja, Julia Chu, Christopher C. Dvorak, Lynn C. O'Donnell, Yongping Wang, Nancy J. Bunin, and Mitch S. Cairo: Treating Children, Adolescents, and Young Adults (CAYA) with Refractory Viral Infections in Primary Immunodeficiencies (PID), or Post Solid Organ Transplant (SOT) or Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) with Virus Specific T- Lymphocytes (vCTLs). Pediatric Transplantation & cellular Therapy Consortium annual meeting May 2022.
Allison Barz Leahy, Yimei Li, Julie-An Talano, Caitlin W. Elgarten, Alix E. Seif, Yongping Wang, Bryon Johnson, Dimitri S. Monos, Stephan Kadauke, Timothy S. Olson, Jason Freedman, Lisa Wray, Stephan A. Grupp, Nancy Bunin: Unrelated donor α/β T-cell and B-cell-depleted HSCT for the treatment of pediatric acute leukemia. Blood Advances 6(4): 1175-1185, Feb 2022.
Joseph H Oved, Caitlin W Elgarten, Yongping Wang, Stephan Kadauke, Dimitri S. Monos, David M. Barrett, Stephan A. Grupp, Nancy Bunin, Timothy S. Olson: Ex Vivo T-Cell Receptor αβ +/CD19 +depletion of Peripheral Stem Cell Grafts for Pediatric Patients with Bone Marrow Failure (BMF) Undergoing Unrelated Donor Transplantation. Blood 138 Supp: 171, Nov 2021.
Yaya Chu, Jordan Milner, Margaret Lamb, Elena Maryamchik, Olivia Rigot, Janet Ayello, Lauren Harrison, Rosemarie Shaw, Greg K. Behbehani, Elaine R. Mardis, Katherine E Miller, Lakshmi Prakruthi Rao Venkata, Hsiaochi Chang, Dean Anthony Lee, Elana Y. Rosenthal, Stephan Kadauke, Nancy Bunin, Julie-An Talano, Bryon Johnson, Yongping Wang, Mitchell S. Cairo: Manufacture and Immunological Characterization of GMP-compliant functional SARS-COV-2 cytotoxic T lymphocytes (CTLs) utilizing the CliniMACS Cytokine Capture System. Blood 138 Supp: 476, Nov 2021.
Olivia Rigot, Janet Ayello, Bernadette Fallon, Lin Marie Colon, Robert Kuhns, Lauren Harrison, Rosemarie Shaw, Sandra Fabricatore, Isabel D Gonzalez, Allyson Flower, Bryon D Johnson, Yongping Wang, Mitchell S Cairo: Optimization of Gating of IFN-Gamma Positive Viral Specific Cytotoxic T-Cells (vCTLs) Following Viral Peptivators® Stimulation Utilizing the Cytokine Capture System on the Clinimacs® Prodigy: Quality Control of the Viral CTL Consortium (VIRCTL). Transplant Cell Ther 27 3S: S356, Feb 2021.