Michael G.S. Shashaty, MD, MSCE

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
5039 W Gates
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-615-5031
Education:
BS (Biology)
Georgetown University, 1997.
MD (Medicine)
Vanderbilt University School of Medicine, 2003.
MSCE (Clinical Epidemiology)
Perelman School of Medicine, University of Pennsylvania, 2010.
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Description of Research Expertise

Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness and populations.

Dr. Shashaty has formal training in the clinical practice of pulmonary and critical care medicine, biostatistical and epidemiologic methods, and protein, gene expression, and genomic analyses of human biospecimens. He is the principal investigator for the Lung Transplant Outcomes Group–Acute Kidney Injury (LTOG-AKI) study, a multicenter prospective cohort of lung transplant recipients (n>1800) designed to study the clinical and molecular epidemiology of post-lung transplant AKI. The primary focus of this study is to determine clinical characteristics and novel blood and urine biomarkers that are useful for AKI prediction and may provide insight into molecular mechanisms of AKI after transplantation.

Dr. Shashaty is also the principal investigator for the ongoing Penn Trauma Organ Dysfunction Study (PETROS), a cohort of critically ill trauma patients (n>1300), and a co-investigator in Penn’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, for which he leads studies of AKI. Current areas of study in these cohorts include elucidating mechanisms underlying the association of obesity and AKI, the relevance of programmed cell necrosis in human AKI and ARDS, circulating cell-free DNA as a mechanistic contributor to AKI and ARDS, and genetic risk factors for AKI.

Description of Clinical Expertise

Dr. Shashaty is specialty-trained in internal medicine, pulmonary diseases, and critical care medicine. He is an attending physician at the Hospital of the University of Pennsylvania (HUP), with the majority of his clinical time spent in the medical intensive care unit. He also attends on and is the service lead for the Critical Care Outreach and Procedure Service (CCOPS).

Dr. Shashaty is currently the Rapid Response Medical Director at HUP. In this capacity, he works with a multidisciplinary team to provide oversight, design and conduct training, and pursue quality improvement initiatives in the areas of clinical emergencies and management of cardiac arrest. He has played a central role in adapting HUP's clinical emergencies team to the COVID-19 pandemic.

Dr. Shashaty is actively engaged in teaching fellows, house officers, medical students, and advanced practice providers through both HUP clinical services, classes at the Perelman School of Medicine, and training programs at the Penn School of Nursing.

Selected Publications

Sjoding MW, Taylor D, Motyka J, Lee E, Co I, Claar D, McSparron JI, Ansari S, Kerlin MP, Rielly JP, Shashaty MGS, Anderson BJ, Jones TK, Drebin HM, Ittner CAG, Meyer NJ, Iwashyna TJ, Ward KR, Gillies CE: Deep Learning to Detect Findings of the Acute Respiratory Distress Syndrome on Chest Radiographs: A Retrospective Study with External Validation. Lancet Digital Health Mar 2021 Notes: accepted for publication.

Oscar J.L. Mitchell, Eugene Yuriditsky, Nicholas J. Johnson, Olivia Doran, David G. Buckler, Stacie Neefe, Raghu R. Seethala, Sergey Motov, Ari Moskowitz, Jarone Lee, Kelly M. Griffin, Michael G. S. Shashaty, James M. Horowitz, Benjamin S. Abella on behalf of the Coronavirus 2019 In-Hospital Cardiac Arrest (COVID IHCA) Study Group: In-Hospital Cardiac Arrest in Patients with Coronavirus 2019. Resuscitation Jan 2021 Notes: accepted for publication.

Anesi GL, Jablonski J, Harhay MO, Atkins JH, Bajaj J, Baston C, Brennan PJ, Candeloro CL, Catalano LM, Cereda MF, Chandler JM, Christie JD, Collins T, Courtright KR, Fuchs BD, Gordon E, Greenwood JC, Gudowski S, Hanish A, Hanson CW III, Heuer M, Kinniry P, Kornfield ZN, Kruse GB, Lane-Fall M, Martin ND, Mikkelsen ME, Negoianu D, Pascual JL, Patel MB, Pugliese SC, Qasim ZA, Reilly JP, Salmon J, Schweickert WD, Scott MJ, Shashaty MGS, Sicoutris CP, Wang JK, Wang W, Wani AA, Anderson BJ, Gutsche JT: Characteristics, outcomes, and trends of patients with COVID-19-related critical illness at a learning health system in the U.S. Annals of Internal Medicine Jan 2021 Notes: accepted for publication.

Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff ED, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell JA, Christiani DC, Wurfel MM, Lanken PN, Reilly MP, Christie JD: The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness. J Clin Invest Sep 2020 Notes: epub ahead of print.

Miano TA, Shashaty M, Yang W, Brown JR, Zuppa A, Hennessy S : Effect of renin-angiotensin system inhibitors on the comparative nephrotoxicity of NSAIDs and opioids during hospitalization. Kidney360 1(7): 604-613, Jul 2020.

Miano, T. A., Yang, W., Shashaty, M. G. S., Zuppa, A., Brown, J. R., Hennessy, S.: The Magnitude of the Warfarin-Amiodarone Drug-Drug Interaction Varies With Renal Function: A Propensity-Matched Cohort Study. Clin Pharmacol Ther 107(6): 1446-1456, Jun 2020.

Vasquez, C. R., DiSanto, T., Reilly, J. P., Forker, C. M., Holena, D. N., Wu, Q., Lanken, P. N., Christie, J. D., Shashaty, M. G. S.: Relationship of body mass index, serum creatine kinase, and acute kidney injury after severe trauma. J Trauma Acute Care Surg Page: epub ahead of print, Apr 2020.

Hatchimonji, J. S., Kaufman, E. J., Vasquez, C. R., Shashaty, M. G. S., Martin, N. D., Holena, D. N.: Obesity is Associated With Mortality and Complications After Trauma: A State-Wide Cohort Study. J Surg Res 247: 14-20, Mar 2020.

Miano Todd A, Flesch Judd D, Feng Rui, Forker Caitlin M, Brown Melanie, Oyster Michelle, Kalman Laurel, Rushefski Melanie, Cantu Edward, Porteus Mary, Yang Wei, Russel Localio Jd A, Diamond Joshua M, Christie Jason D, Shashaty Michael G S: Early Tacrolimus Concentrations After Lung Transplant are Predicted by Combined Clinical and Genetic Factors and Associated with Acute Kidney Injury. Clinical pharmacology and therapeutics 107(2): 462-470, Feb 2020.

Faust Hilary E, Reilly John P, Anderson Brian J, Ittner Caroline A G, Forker Caitlyn M, Zhang Peggy, Weaver Benjamin A, Holena Daniel N, Lanken Paul N, Christie Jason D, Meyer Nuala J, Mangalmurti Nilam S, Shashaty Michael G S: Plasma Mitochondrial DNA Levels are Associated with Acute Respiratory Distress Syndrome in Trauma and Sepsis Patients. Chest 157(1): 67-76, Jan 2020.

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Last updated: 03/15/2021
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