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Mortimer Poncz, MD

Mortimer Poncz, MD

faculty photo
Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of Research Expertise

Research Interests
Role of platelets in thrombus development

Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.

Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.

Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res

Selected Publications

Greineder Colin F, Hood Elizabeth D, Yao Anning, Khoshnejad Makan, Brenner Jake S, Johnston Ian H, Poncz Mortimer, Gottstein Claudia, Muzykantov Vladimir R: Molecular engineering of high affinity single-chain antibody fragment for endothelial targeting of proteins and nanocarriers in rodents and humans. Journal of controlled release : official journal of the Controlled Release Society 226: 229-237, Feb 2016.

Zhang Nanyan, Zhi Huiying, Curtis Brian R, Rao Sridhar, Jobaliya Chintan, Poncz Mortimer, French Deborah L, Newman Peter J: CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. Blood 127(6): 675-80, Feb 2016.

Parker Zahra Folasade, Rux Ann H, Riblett Amber M, Lee Fang-Hua, Rauova Lubica, Cines Douglas B, Poncz Mortimer, Sachais Bruce S, Doms Robert W: Platelet-Factor 4 (PF4) inhibits and enhances HIV-1 infection in a concentration-dependent manner by modulating viral attachment. AIDS research and human retroviruses Feb 2016.

Sim Xiuli, Poncz Mortimer, Gadue Paul, French Deborah L: Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood Jan 2016.

Tutwiler Valerie, Madeeva Daria, Ahn Hyun Sook, Andrianova Izabella, Hayes Vincent, Zheng X Long, Cines Douglas B, McKenzie Steven E, Poncz Mortimer, Rauova Lubica: Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. Blood 127(4): 464-72, Jan 2016.

Fuentes Rudy E, Zaitsev Sergei, Ahn Hyun Sook, Hayes Vincent, Kowalska M Anna, Lambert Michele P, Wang Yuhuan, Siegel Donald L, Bougie Daniel W, Aster Richard H, Myers Daniel D, Stepanova Victoria, Cines Douglas B, Muzykantov Vladimir R, Poncz Mortimer: A chimeric platelet-targeted urokinase prodrug selectively blocks new thrombus formation. The Journal of clinical investigation Dec 2015.

Zhou Junsong, Wu Yi, Wang Lu, Rauova Lubica, Hayes Vincent M, Poncz Mortimer, Essex David W: The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. The Journal of clinical investigation 125(12): 4391-406, Dec 2015.

Lambert M P, Meng R, Xiao L, Harper D C, Marks M S, Kowalska M A, Poncz M: Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules. Journal of thrombosis and haemostasis : JTH 13(10): 1888-99, Oct 2015.

Chacko Ann-Marie, Han Jingyan, Greineder Colin F, Zern Blaine J, Mikitsh John L, Nayak Madhura, Menon Divya, Johnston Ian H, Poncz Mortimer, Eckmann David M, Davies Peter F, Muzykantov Vladimir R: Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement. ACS nano 9(7): 6785-93, Jul 2015.

Lyde R, Sabatino D, Sullivan S K, Poncz M: Platelet-delivered therapeutics. Journal of thrombosis and haemostasis : JTH 13 Suppl 1: S143-50, Jun 2015.

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Last updated: 07/08/2016
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