Mortimer Poncz, MD

faculty photo
Professor of Pediatrics (Hematology)
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Department: Pediatrics
Graduate Group Affiliations

Contact information
3615 Civic Center Blvd.
Division of Hematology
The Children's Hospital of Philadelphia
Abramson Research Bdg. Rm. 317
Philadelphia, PA 19104-4318
Office: (215) 590-3574
Fax: (267) 426-5476
Education:
B.S.
Columbia University, 1972.
M.D.
University of Pennsylvania, 1976.
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Description of Research Expertise

Research Interests
Role of platelets in thrombus development

Key words: platelet; megakaryocyte; hematopoiesis; thrombosis.

Description of Research
My research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.

Rotation Projects for 2006-2007
1. Murine models of thrombosis.
2. Regulation of megakaryocyte gene expression.
3. Gene therapy lentiviral studies for bleeding disorders. Chemokine sin thrombosis and angiogenesis.

Lab personnel:
1 grad student
1 MD post-doc
3 PhD post-docs
5 lab techs
1 Assist Prof Res

Selected Publications

Lee K, Ahn HS, Estevez B, Poncz M.: RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects. Blood 141: 260-270, Jan 2023.

Ngo ATP, Sarkar A, Yarovoi I, Levine ND, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K.: Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury. bioRxiv Jan 2023.

Cai Z, Bdeir K, Yarovoi SV, Rauova L, Arepally GM, Khandelwal S, Rollin J, Gruel Y, Zaitsev S, Poncz M, Greene MI, Cines DB.: Modulation of ultralarge immune complexes in heparin-induced thrombocytopenia. J Thromb Haemost Dec 2022.

Le HT, Golla K, Karimi R, Hughes MR, Lakschevitz F, Cines DB, Kowalska MA, Poncz M, McNagny KM, Häkkinen L, Kim H.: Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts. Sci Rep 12: 18636, Nov 2022.

Jalagadugula G, Mao G, Goldfinger LE, Wurtzel J, Del Carpio-Cano F, Lambert MP, Estevez B, French DL, Poncz M, Rao AK.: Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency. Blood Adv 6: 5100-5112, Sep 2022.

Mauro KD, Lambert MP, Kowalska MA, Thawley VJ, Poncz M, Otto CM.: Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis. Front Vet Sci 9: 862308, Apr 2022.

Apostolidis SA, Sarkar A, Giannini HM, Goel RR, Mathew D, Suzuki A, Baxter AE, Greenplate AR, Alanio C, Abdel-Hakeem M, Oldridge DA, Giles JR, Wu JE, Chen Z, Huang YJ, Belman J, Pattekar A, Manne S, Kuthuru O, Dougherty J, Weiderhold B, Weisman AR, Ittner CAG, Gouma S, Dunbar D, Frank I, Huang AC, Vella LA; UPenn COVID Processing Unit; Reilly JP, Hensley SE, Rauova L, Zhao L, Meyer NJ, Poncz M, Abrams CS, Wherry EJ.: Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19. Front Immunol 13: 834988, Mar 2022.

Zhou J, Wu Y, Rauova L, Koma G, Wang L, Poncz M, Li H, Liu T, Fong KP, Bennett JS, Kunapuli SP, Essex DW.: A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. Blood 139: 2050-2065, Mar 2022.

Khandelwal S, Barnes A, Rauova L, Sarkar A, Rux AH, Yarovoi SV, Zaitsev SS, Lambris JD, Myoung SS, Johnson A, Lee GM, Duarte M, Poncz M, Arepally GM, Cines DB.: Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes. Blood 138: 2106-2116, Nov 2021.

Rauova L, Poncz M.: Understanding VITT(ual) reality. Blood 138: 285-286, Jul 2021.

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Last updated: 02/07/2023
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