Sandhitsu Das, Ph.D.

Research Associate Professor of Neurology
Department: Neurology
Contact information
University of Pennsylvania
3700 Hamilton Walk, Fl 6
Philadelphia, PA 19104
3700 Hamilton Walk, Fl 6
Philadelphia, PA 19104
Office: (267) 408-3001
Fax: (215) 573-2701
Fax: (215) 573-2701
Education:
B. Tech (Electrical Engineering)
Indian Institute of Technology, 1997.
M. Tech (Digital Signal Processing)
Indian Institute of Technology, 1999.
Ph.D. (Neuroengineering)
University of Pennsylvania, 2006.
Permanent linkB. Tech (Electrical Engineering)
Indian Institute of Technology, 1997.
M. Tech (Digital Signal Processing)
Indian Institute of Technology, 1999.
Ph.D. (Neuroengineering)
University of Pennsylvania, 2006.
Selected Publications
Brown CA, Das SR, Cousins KAQ, Tropea TF, Plotkin AC, Detre JA, Yushkevich PA, McMillan CT, Lee EB, Shaw LM, Nasrallah IM; Alzheimer’s Disease Neuroimaging Initiative; Wolk DA.: Tau Burden is Best Captured by Magnitude and Extent: Tau-MaX as a Measure of Global Tau. medRxiv Jan 2025.Hrybouski S, Das SR, Xie L, Brown CA, Flamporis M, Lane J, Nasrallah IM, Detre JA, Yushkevich PA, Wolk DA.: BOLD amplitude correlates of preclinical Alzheimer's disease. Neurobiol Aging 2025.
Cohen JS, Phillips J, Das SR, Olm CA, Radhakrishnan H, Rhodes E, Cousins KAQ, Xie SX, Nasrallah IM, Yushkevich PA, Wolk DA, Lee EB, Weintraub D, Irwin DJ, McMillan CT.: Posterior hippocampal sparing in Lewy body disorders with Alzheimer's copathology: An in vivo MRI study. Neuroimage Clin 2025.
Xie L, Das SR, Li Y, Wisse LEM, McGrew E, Lyu X, DiCalogero M, Shah U, Ilesanmi A, Denning AE, Brown CA, Cohen J, Sreepada L, Dong M, Sadeghpour N, Khandelwal P, Ittyerah R, Ravikumar S, Sadaghiani S, Hrybouski S, de Flores R, Gibson E, Yushkevich PA, Wolk DA; Alzheimer's Disease Neuroimaging Initiative.: A multi-cohort study of longitudinal and cross-sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults. Alzheimers Dement 2025.
Taghvaei M, Dolui S, Sadaghiani S, Shakibajahromi B, Brown C, Khandelwal P, Xie SX, Das S, Yushkevich PA, Wolk DA, Detre JA.: Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum. Alzheimers Dement 2025.
Chen C, Das SR, Tisdall MD, Hu F, Chen AA, Yushkevich PA, Wolk DA, Shinohara RT; Alzheimer's Disease Neuroimaging Initiative.: Subject-Level Segmentation Precision Weights for Volumetric Studies Involving Label Fusion. Hum Brain Mapp 45: e70082, Dec 2024.
Duong MT, Das SR, Khandelwal P, Lyu X, Xie L, McGrew E, Dehghani N, McMillan CT, Lee EB, Shaw LM, Yushkevich PA, Wolk DA, Nasrallah IM.: Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer and Lewy body disease. Brain Nov 2024.
Denning AE, Ittyerah R, Levorse LM, Sadeghpour N, Athalye C, Chung E, Ravikumar S, Dong M, Duong MT, Li Y, Ilesanmi A, Sreepada LP, Sabatini P, Lowe M, Bahena A, Zablah J, Spencer BE, Watanabe R, Kim B, Sørensen MH, Khandelwal P, Brown C, Hrybouski S, Xie SX, de Flores R, Robinson JL, Schuck T, Ohm DT, Arezoumandan S, Porta S, Detre JA, Insausti R, Wisse LEM, Das SR, Irwin DJ, Lee EB, Wolk DA, Yushkevich PA.: Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum. Acta Neuropathol 148: 37, Sep 2024.
Altmann A, Aksman LM, Oxtoby NP, Young AL; ADNI; Alexander DC, Barkhof F, Shoai M, Hardy J, Schott JM.: Towards cascading genetic risk in Alzheimer's disease. Brain 147: 2680-2690, Aug 2024.
Dong M, Xie L, Das SR, Wang J, Wisse LEM, deFlores R, Wolk DA, Yushkevich PA.: Regional Deep Atrophy: a Self-Supervised Learning Method to Automatically Identify Regions Associated With Alzheimer's Disease Progression From Longitudinal MRI. Imaging Neuroscience Aug 2024.