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Paul J. De Weer
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Isaac Ott Emeritus Professor of Physiology
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Department: Physiology
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Contact information
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Room B400 Richard Building
3a 3700 Hamilton Walk
Philadelphia, PA 19104-6085
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3a 3700 Hamilton Walk
Philadelphia, PA 19104-6085
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Office: 2158988725
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Email:
DEWEER@MAIL.MED.UPENN.EDU
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DEWEER@MAIL.MED.UPENN.EDU
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Education:
21 9 B.S. 2b (Preclinical Medicine/Chemistry) c
37 University of Leuven (Belgium), 1959.
21 9 M.D. c
36 University of Leuven, Belgium, 1963.
21 9 M.S. 1d (Medical Sciences) c
2d University of Leuven, 1964.
21 a Ph.D. 17 (Biophysics) c
3c University of Maryland at Baltimore, 1969.
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Permanent link21 9 B.S. 2b (Preclinical Medicine/Chemistry) c
37 University of Leuven (Belgium), 1959.
21 9 M.D. c
36 University of Leuven, Belgium, 1963.
21 9 M.S. 1d (Medical Sciences) c
2d University of Leuven, 1964.
21 a Ph.D. 17 (Biophysics) c
3c University of Maryland at Baltimore, 1969.
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Description of Research Expertise
63 Member of the Corporation, Marine Biological Laboratory (Woods Hole, Massachusetts)26 29
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e9 Rakowski, R.F., Gadsby, D.C., De Weer, P.: Single ion occupancy and steady-state gating of Na channels in squid giant axon. J. Gen. Physiol. 119: 235-249, 2002.
13e Jans, D., De Weer, P., Srinivas, S.P., Larivière, E., Simaels, J., Van Driessche, W.: Mg2+-sensitive non-capacitative basolateral Ca2+ entry secondary to cell swelling in the polarized renal A6 epithelium. J. Physiol. (Lond.) 541: 91-101, 2002.
fa De Weer, P., Gadsby, D.C., Rakowski, R.F.: Voltage dependence of the apparent affinity for external Na+ of the backward-running sodium pump. J. Gen. Physiol. 117: 315-328, 2001.
a7 De Weer, P.: A century of thinking about cell membranes. Ann. Rev. Physiol. 62: 919-926, 2000.
10a De Weer, P., Gadsby, D.C., Rakowski, R.F.: The Na/K-ATPase: a current-generating enzyme. Na/K-ATPase and Related ATPases. Taniguchi, K., Kaya, S. (eds.). Elsevier; Amsterdam, Page: 27-34, 2000.
dd Holmgren, M., Wagg, J., Bezanilla, F., Rakowski, R.F., De Weer, P., Gadsby, D.C.: Three distinct and sequential steps in the release of sodium ions by the Na+/K+ ATPase. 33 Nature 403: 898-901, 2000.
cc De Weer, P.: No easy way out (or in): kinetic model for Na:GABA cotransport. J. Gen. Physiol. 114: 427-428, 1999 Notes: Commentary.
171 Holmgren, M., Wagg, J., Bezanilla, F., Rakowski, R.F., De Weer, P., Gadsby, D.C.: Strictly sequential extracellular release of 3 Na+ ions revealed by voltage jump-induced presteady-state charge movements. 1999 Notes: Presented at the Proc. IXth Internat. Na Pump Conference, Sapporo, Japan, 1999.
fd Wagg, J., Holmgren, M., Gadsby, D.C., Bezanilla, F., Rakowski, R.F., De Weer, P.: Na/K pump-mediated transient currents indicate sequential Na+ release. Biophys. J. 74: 338a, 1998.
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Selected Publications
e0 Rakowski, R.F., Artigas, P., Holmgren, M., Gadsby, D.C., De Weer, P.: Na ion occupancy of the channels opened by palytoxin. Biophys. J. 84: 320a, 2003.e9 Rakowski, R.F., Gadsby, D.C., De Weer, P.: Single ion occupancy and steady-state gating of Na channels in squid giant axon. J. Gen. Physiol. 119: 235-249, 2002.
13e Jans, D., De Weer, P., Srinivas, S.P., Larivière, E., Simaels, J., Van Driessche, W.: Mg2+-sensitive non-capacitative basolateral Ca2+ entry secondary to cell swelling in the polarized renal A6 epithelium. J. Physiol. (Lond.) 541: 91-101, 2002.
fa De Weer, P., Gadsby, D.C., Rakowski, R.F.: Voltage dependence of the apparent affinity for external Na+ of the backward-running sodium pump. J. Gen. Physiol. 117: 315-328, 2001.
a7 De Weer, P.: A century of thinking about cell membranes. Ann. Rev. Physiol. 62: 919-926, 2000.
10a De Weer, P., Gadsby, D.C., Rakowski, R.F.: The Na/K-ATPase: a current-generating enzyme. Na/K-ATPase and Related ATPases. Taniguchi, K., Kaya, S. (eds.). Elsevier; Amsterdam, Page: 27-34, 2000.
dd Holmgren, M., Wagg, J., Bezanilla, F., Rakowski, R.F., De Weer, P., Gadsby, D.C.: Three distinct and sequential steps in the release of sodium ions by the Na+/K+ ATPase. 33 Nature 403: 898-901, 2000.
cc De Weer, P.: No easy way out (or in): kinetic model for Na:GABA cotransport. J. Gen. Physiol. 114: 427-428, 1999 Notes: Commentary.
171 Holmgren, M., Wagg, J., Bezanilla, F., Rakowski, R.F., De Weer, P., Gadsby, D.C.: Strictly sequential extracellular release of 3 Na+ ions revealed by voltage jump-induced presteady-state charge movements. 1999 Notes: Presented at the Proc. IXth Internat. Na Pump Conference, Sapporo, Japan, 1999.
fd Wagg, J., Holmgren, M., Gadsby, D.C., Bezanilla, F., Rakowski, R.F., De Weer, P.: Na/K pump-mediated transient currents indicate sequential Na+ release. Biophys. J. 74: 338a, 1998.
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