Paul J. De Weer
Isaac Ott Emeritus Professor of Physiology
Department: Physiology
Contact information
Room B400 Richard Building
3700 Hamilton Walk
Philadelphia, PA 19104-6085
3700 Hamilton Walk
Philadelphia, PA 19104-6085
Office: 2158988725
Email:
DEWEER@MAIL.MED.UPENN.EDU
DEWEER@MAIL.MED.UPENN.EDU
Education:
B.S. (Preclinical Medicine/Chemistry)
University of Leuven (Belgium), 1959.
M.D.
University of Leuven, Belgium, 1963.
M.S. (Medical Sciences)
University of Leuven, 1964.
Ph.D. (Biophysics)
University of Maryland at Baltimore, 1969.
Permanent linkB.S. (Preclinical Medicine/Chemistry)
University of Leuven (Belgium), 1959.
M.D.
University of Leuven, Belgium, 1963.
M.S. (Medical Sciences)
University of Leuven, 1964.
Ph.D. (Biophysics)
University of Maryland at Baltimore, 1969.
Description of Research Expertise
Member of the Corporation, Marine Biological Laboratory (Woods Hole, Massachusetts)Selected Publications
Rakowski, R.F., Artigas, P., Holmgren, M., Gadsby, D.C., De Weer, P.: Na ion occupancy of the channels opened by palytoxin. Biophys. J. 84: 320a, 2003.Rakowski, R.F., Gadsby, D.C., De Weer, P.: Single ion occupancy and steady-state gating of Na channels in squid giant axon. J. Gen. Physiol. 119: 235-249, 2002.
Jans, D., De Weer, P., Srinivas, S.P., Larivière, E., Simaels, J., Van Driessche, W.: Mg2+-sensitive non-capacitative basolateral Ca2+ entry secondary to cell swelling in the polarized renal A6 epithelium. J. Physiol. (Lond.) 541: 91-101, 2002.
De Weer, P., Gadsby, D.C., Rakowski, R.F.: Voltage dependence of the apparent affinity for external Na+ of the backward-running sodium pump. J. Gen. Physiol. 117: 315-328, 2001.
De Weer, P.: A century of thinking about cell membranes. Ann. Rev. Physiol. 62: 919-926, 2000.
De Weer, P., Gadsby, D.C., Rakowski, R.F.: The Na/K-ATPase: a current-generating enzyme. Na/K-ATPase and Related ATPases. Taniguchi, K., Kaya, S. (eds.). Elsevier; Amsterdam, Page: 27-34, 2000.
Holmgren, M., Wagg, J., Bezanilla, F., Rakowski, R.F., De Weer, P., Gadsby, D.C.: Three distinct and sequential steps in the release of sodium ions by the Na+/K+ ATPase. Nature 403: 898-901, 2000.
De Weer, P.: No easy way out (or in): kinetic model for Na:GABA cotransport. J. Gen. Physiol. 114: 427-428, 1999 Notes: Commentary.
Holmgren, M., Wagg, J., Bezanilla, F., Rakowski, R.F., De Weer, P., Gadsby, D.C.: Strictly sequential extracellular release of 3 Na+ ions revealed by voltage jump-induced presteady-state charge movements. 1999 Notes: Presented at the Proc. IXth Internat. Na Pump Conference, Sapporo, Japan, 1999.
Wagg, J., Holmgren, M., Gadsby, D.C., Bezanilla, F., Rakowski, R.F., De Weer, P.: Na/K pump-mediated transient currents indicate sequential Na+ release. Biophys. J. 74: 338a, 1998.