Eugene Khandros, MD, PhD
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
Abramson Research Center, 316A
3615 Civic Center Blvd
Philadelphia, PA 19104
3615 Civic Center Blvd
Philadelphia, PA 19104
Lab: (215) 590-4461
Email:
khandrose@chop.edu
khandrose@chop.edu
Publications
Education:
BA (Biochemistry)
Columbia University, 2005.
PhD (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2011.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2013.
Permanent linkBA (Biochemistry)
Columbia University, 2005.
PhD (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2011.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2013.
Description of Clinical Expertise
Pediatric hematologySickle cell disease
Thalassemia
Description of Research Expertise
HemoglobinopathiesFetal hemoglobin
Red blood cell disorders
Selected Publications
Vermunt MW, Luan J, Zhang Z, Thrasher AJ, Huang A, Saari MS, Khandros E, Beagrie RA, Zhang S, Vemulamada P, Brilleman M, Lee K, Yano JA, Giardine BM, Keller CA, Hardison RC, Blobel GA: Gene silencing dynamics are modulated by transiently active regulatory elements Molecular Cell 83(5): 715-730, Mar 2023.Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine BM, Abdulmalik O, Shi J, Hardison RC, Blobel GA: Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood Mar 2023.
Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA: HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nature Genetics 54(9): 1417-1426, Sep 2022.
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nature Genetics 54(6): 874-884, Jun 2022.
Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallieres M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA: Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Blood Advances May 2022.
Braun TW, Kuoch MK, Khandros E, Li H: FACS and immunomagnetic isolation of early erythroid progenitor cells from mouse fetal liver. STAR Protocols 3(1): 101070, Mar 2022.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J: ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Molecular Cell 81(17): 364-3622, Sep 2021.
Khandros E and Blobel G.: Heterogeneity of fetal hemoglobin production in adult red blood cells. Current Opinion in Hematology 28(3): 164-170, May 2021.
Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA. : HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation. Blood Advances 4(18): 4560-4572, Sep 2020.
Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine BM, Qin K, Abdulmalik O, Hardison R, Shi J, Blobel GA.: HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. Blood 135(24): 2121-2132, Jun 2020.