Eugene Khandros, MD, PhD
Assistant Professor of Pediatrics (Hematology)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Abramson Research Center, 316A
3615 Civic Center Blvd
Philadelphia, PA 19104
3615 Civic Center Blvd
Philadelphia, PA 19104
Lab: (215) 590-4461
Email:
khandrose@chop.edu
khandrose@chop.edu
Publications
Education:
BA (Biochemistry)
Columbia University, 2005.
PhD (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2011.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2013.
Permanent linkBA (Biochemistry)
Columbia University, 2005.
PhD (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2011.
MD (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2013.
Description of Clinical Expertise
Pediatric hematologySickle cell disease
Thalassemia
Description of Research Expertise
HemoglobinopathiesFetal hemoglobin
Red blood cell disorders
Selected Publications
Huang P, Peslak SA, Shehu V, Keller CA, Giardine BM, Shi J, Hardison RC, Blobel GA, Khandros E: Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching. Blood 143(19): 1980-1991, May 2024.Khandros E, Blobel GA: Elevating fetal hemoglobin - recently discovered regulators and mechanisms. Blood May 2024.
Lechauve C, Keith J, Fernandez AG, Khandros E, Mayberry K, Mayuranathan T, Palmer LE, Qiu X, Sheppard H, Telange R, Herz HM, Weiss MJ: Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model. Blood Advances Mar 2024.
Khandros E, Kwiatkowski JL: Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin Chain Synthesis. Wintrobe's Clinical Hematology, 15th edition. Means, RT (eds.). Wolters Kluwer, Page: 883-932, July 2023.
Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine BM, Abdulmalik O, Shi J, Hardison RC, Blobel GA: Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood 141(22): 2756-2770, Jun 2023.
Vermunt MW, Luan J, Zhang Z, Thrasher AJ, Huang A, Saari MS, Khandros E, Beagrie RA, Zhang S, Vemulamada P, Brilleman M, Lee K, Yano JA, Giardine BM, Keller CA, Hardison RC, Blobel GA: Gene silencing dynamics are modulated by transiently active regulatory elements Molecular Cell 83(5): 715-730, Mar 2023.
Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA: HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nature Genetics 54(9): 1417-1426, Sep 2022.
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nature Genetics 54(6): 874-884, Jun 2022.
Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallieres M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA: Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Blood Advances May 2022.
Braun TW, Kuoch MK, Khandros E, Li H: FACS and immunomagnetic isolation of early erythroid progenitor cells from mouse fetal liver. STAR Protocols 3(1): 101070, Mar 2022.