Eugene Khandros, MD, PhD
Assistant Professor of Pediatrics (Hematology)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Abramson Research Center, 316A
3615 Civic Center Blvd
Philadelphia, PA 19104
Abramson Research Center, 316A
3615 Civic Center Blvd
Philadelphia, PA 19104
Lab: (215) 590-4461
Email:
khandrose@chop.edu
khandrose@chop.edu
Publications
Education:
BA (Biochemistry)
Columbia University, 2005.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, 2011.
MD (Medicine)
University of Pennsylvania School of Medicine, 2013.
Permanent linkBA (Biochemistry)
Columbia University, 2005.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, 2011.
MD (Medicine)
University of Pennsylvania School of Medicine, 2013.
Description of Clinical Expertise
Pediatric hematologySickle cell disease
Thalassemia
Description of Research Expertise
HemoglobinopathiesFetal hemoglobin
Red blood cell disorders
Selected Publications
Gibson NM, Khandros E, Elgarten CW, Worster E, Monos DS, Thompson AA, Kwiatkowski JL, Olson T: Impact of HLA Alloimmunization in Gene-Modified Autologous Stem Cell Transplant For Transfusion-Dependent Thalassemia. Blood Mar 2025.Lechauve C, Keith J, Fernandez AG, Khandros E, Mayberry K, Mayuranathan T, Palmer LE, Qiu X, Sheppard H, Telange R, Herz HM, Weiss MJ: Ancestral β-globin gene haplotypes modify β-thalassemia severity in a mouse model. Blood Advances Page: doi: 10.1182, Sep 2024 Notes: epub ahead of print.
Khandros E, Blobel GA: Elevating fetal hemoglobin - recently discovered regulators and mechanisms. Blood 144(8): 845-852, Aug 2024.
Huang P, Peslak SA, Shehu V, Keller CA, Giardine BM, Shi J, Hardison RC, Blobel GA, Khandros E: Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching. Blood 143(19): 1980-1991, May 2024.
Khandros E, Kwiatkowski JL: Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin Chain Synthesis. Wintrobe's Clinical Hematology, 15th edition. Means, RT (eds.). Wolters Kluwer, Page: 883-932, July 2023.
Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine BM, Abdulmalik O, Shi J, Hardison RC, Blobel GA: Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood 141(22): 2756-2770, Jun 2023.
Vermunt MW, Luan J, Zhang Z, Thrasher AJ, Huang A, Saari MS, Khandros E, Beagrie RA, Zhang S, Vemulamada P, Brilleman M, Lee K, Yano JA, Giardine BM, Keller CA, Hardison RC, Blobel GA: Gene silencing dynamics are modulated by transiently active regulatory elements Molecular Cell 83(5): 715-730, Mar 2023.
Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallieres M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA: Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Blood Advances 6(23): 5956-5968, Dec 2022.
Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA: HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nature Genetics 54(9): 1417-1426, Sep 2022.
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nature Genetics 54(6): 874-884, Jun 2022.