Michele M Kim, Ph.D.

faculty photo
Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
3400 Civic Center Blvd.
Perelman Center for Advanced Medicine
West Pavilion
Philadelphia, PA 19104
BA (Physics, Biophysics)
University of Pennsylvania, 2012.
MS (Physics)
University of Pennsylvania, 2012.
PhD (Physics)
University of Pennsylvania, 2017.
Permanent link
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Description of Clinical Expertise

Therapeutic Medical Physics

Description of Research Expertise

Small Animal Photon/Proton Studies, Proton FLASH, Proton Radiation, Photon Radiation

Selected Publications

Kim MM, Bollinger D, Kennedy C, Zou W, Scheuermann R, Teo BK, Metz JM, Dong L, Li T.: Dosimetric Characterization of the Dual Layer MLC System for an O-Ring Linear Accelerator. Technol Cancer Res Treat 18(1533033819883641), Jan-Dec 2019 Notes: doi: 10.1177/1533033819883641.

M. M. Kim, W. Zou: Ultra-high dose rate FLASH radiation therapy for cancer. Med. Phys. 50 Suppl 1: 1-4, January 2023.

M. M. Kim, I. I. Verginadis, D. Goia, A. Haertter, K. Shoniyozov, W. Zou, A. Maity, T. M. Busch, J. M. Metz, K. A. Cengel, L. Dong, C. Koumenis, E. S. Diffenderfer: Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model. Cancers 13(16): 4244, August 2021 Notes: https://doi.org/10.3390/cancers13164244.

M. M. Kim, A. Darafsheh, J. Schuemann, I. Dokic, O. Lundh, T. Zhao, J. Ramos-Mendez, L. Dong, K. Petersson: Development of Ultra-High Dose Rate Particle Therapy (FLASH). IEEE Trans. Radiat. Plasma. Med. Sci. 6(3): 252-262, Mar 2021.

L. Yin, W. Zou, M. M. Kim, S. M. Avery, R. D. Wiersma, B. K. Teo, L. Dong, E. S. Diffenderfer: Evaluation of two-voltage and three-voltage linear methods for deriving ion recombination correction factors in proton FLASH irradiation. IEEE Trans. Radiat. Plasma. Med. Sci 2021.

M. M. Kim, E. S. Diffenderfer: Proton Therapy Dosimetry. Radiation Therapy Dosimetry. Arash Darafsheh Ed. (eds.). 2021 Notes: In Press ISBN-10: 1138543977.

Kim MM, Darafsheh A: Light Sources and Dosimetry Techniques for Photodynamic Therapy. Photochem Photobiol 96(2): 280-294, Mar 2020.

Diffenderfer ES, Verginadis II, Kim MM, Shoniyozov K, Velalopoulou A, Goia D, Putt M, Hagan S, Avery S, Teo K, Zou W, Lin A, Swisher-McClure S, Koch C, Kennedy AR, Minn A, Maity A, Busch TM, Dong L, Koumenis C, Metz J, Cengel KA.: Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System. Int J Radiat Oncol Biol Phys 106(2): 440-448, Feb 2020.

Kim MM, Irmen P, Shoniyozov K, Verginadis II, Cengel KA, Koumenis C, Metz JM, Dong L, Diffenderfer ES.: Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Phys Med Biol 64(13): 135013, Jul 2019.

Zou W, Diffenderfer ES, Cengel KA, Kim MM, Avery S, Konzer J, Cai Y, Boisseu P, Ota K, Yin L, Wiersma R, Carlson DJ, Fan Y, Busch TM, Koumenis C, Lin A, Metz JM, Teo BK, Dong L: Current Delivery Limitations of Proton PBS for FLASH. Radiother Oncol. 155: 212-218, Nov 2021 Notes: doi: 10.1016/j.radonc.2020.11.002.

M. El Khatib, A. L. Van Slyke, A. Velalopoulou, M. M. Kim, K. Shoniyozov, S. R. Allu, E. S. Diffenderfer, T. M. Busch, R. D. Wiersma, C. J. Koch, S. A. Vinogradov: Ultrafast Tracking of Oxygen Dynamics During Proton FLASH. Int J Radiat Oncol Biol Phys 113(3): 624-634, July 2022 Notes: https://doi.org/10.1016/j.ijrobp.2022.03.016.

Anastasia Velalopoulou, Ilias V. Karagounis, Gwendolyn M. Cramer, Michele M. Kim, Giorgos Skoufos, Denisa Goia, Sarah Hagan, Ioannis I. Verginadis, Khayrullo Shoniyozov, June Chiango, Michelle Cerullo, Kelley Varner, Lutian Yao, Ling Qin, Artemis G. Hatzigeorgiou, Andy J. Minn, Mary Putt, Matthew Lanza, Charles-Antoine Assenmacher, Enrico Radaelli, Jennifer Huck, Eric Diffenderfer, Lei Dong, James Metz, Constantinos Koumenis, Keith A. Cengel, Amit Maity, Theresa M. Busch: FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response. Cancer Research 81(18): 4808–4821, September 2021 Notes: 10.1158/0008-5472.CAN-21-1500.

W. Zou, E. S. Diffenderfer, K. A. Cengel, M. M. Kim, S. Avery, J. Konzer, Y. Cai, P. Boisseu, K. Ota, L. Yin, R. Wiersma, D. J. Carlson, Y. Fan, T. M. Busch, C. Koumenis, A. Lin, J. M. Metz, B. K. Teo, and L. Dong: Characterization of a high-resolution 2D transmission ion chamber for independent validation of proton pencil beam scanning of conventional and FLASH dose delivery. Med. Phys. 48(7): 3948-3957, March 2021.

Barsky AR, Kim MM, Williams GR, Lally BE, Ingram WS, Cengel KA, Feigenberg SJ.: Proton-Beam Therapy: At the Heart of Cardiac Dose-Sparing in Mediastinal Radiotherapy for Thymic Carcinoma. J Thorac Oncol 15(7): 1240-1242, Jul 2020.

H. Sun, M. M. Kim, Y. H. Ong, A. Dimofte, S. Singhal, T. M. Busch, K. A. Cengel, T. C. Zhu: Evaluation Of Detector Position and Light Fluence Distribution Using an Infrared Navigation System during Pleural Photodynamic Therapy Photochemistry and Photobiology 99(22): 814-825, August 2022 Notes: https://doi.org/10.1111/php.13697.

C. M. Wright, D. Y. Lee, M. M. Kim, A. R. Barsky, B.-K. K. Teo, J. N. Lukens, S. Swisher-McClure, A. Lin : Tubarial salivary gland sparing with proton therapy Med. Dosim. 47(3): 222-226, April 2022 Notes: https://doi.org/10.1016/j.meddos.2022.03.001.

C. M. Wright, J. Baron, D. Y. Lee, M.M. Kim, A. R. Barsky, B.-K. K. Teo, J. N. Lukens, S. Swisher-McClure, A. Lin: Dosimetric Results for Adjuvant Proton Radiation Therapy of HPV-Associated Oropharynx Cancer Int. J. Part. Ther. 8(4): 47-54, 2022 Notes: https://doi.org/10.14338%2FIJPT-D-21-00018.

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Last updated: 04/10/2024
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