Alix E. Seif, MD, MPH
Associate Professor of Pediatrics (Oncology) at the Children's Hospital of Philadelphia
Core Faculty, CHOP Clinical Futures
Innovation Faculty, Penn Center for Cancer Care Innovation (PC3I)
Director of Clinical Research, Center for Childhood Cancer Research, Division of Oncology, The Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
The Children's Hospital of Philadelphia
Division of Oncology
3500 Civic Center Blvd, HUB 3529
Philadelphia, PA 19104
Division of Oncology
3500 Civic Center Blvd, HUB 3529
Philadelphia, PA 19104
Office: 215-590-9996
Email:
seifa@chop.edu
seifa@chop.edu
Publications
Education:
BA (Linguistics - Honours, First Class)
McGill University, 1992.
MA (Linguistics)
McGill University, 1995.
MPH (Epidemiology and Biostatistics)
Oregon Health Sciences University, 2002.
MD (Medicine)
Oregon Health Sciences University, 2002.
Certif. (Implementation Science)
University of Pennsylvania, 2025.
Permanent linkBA (Linguistics - Honours, First Class)
McGill University, 1992.
MA (Linguistics)
McGill University, 1995.
MPH (Epidemiology and Biostatistics)
Oregon Health Sciences University, 2002.
MD (Medicine)
Oregon Health Sciences University, 2002.
Certif. (Implementation Science)
University of Pennsylvania, 2025.
Selected Publications
Hongo H, Tasian SK, Seif AE, Rossoff J, Lenzen A, Spitzer B, Dworzak M, Röhl C, Meisel R, Hoffmann M, Stieglitz E, Flotho C: Concurrent Juvenile Myelomonocytic Leukemia and Gliomas in Patients With Neurofibromatosis Type 1. Pediatr Blood Cancer Page: e70060, Feb 2026.Myers RM, Li Y, Liu H, Mumanachit S, Wang L, Leahy AB, Cain LE, DiNofia AM, Diorio C, Freedman JL, Hunger SP, Maude SL, McClory SE, Rheingold SR, Tasian SK, Wray L, Olson TS, Grupp SA, Bunin NJ, Seif AE*, Elgarten CW*: Hematopoietic cell transplantation after CD19-directed CAR T-cell therapy for remission consolidation or relapse treatment in pediatric acute lymphoblastic leukemia. Haematologica Nov 2025 Notes: Online ahead of print.
Walder TA, Meeds HL, Grimley MS, Kleiboeker SB, Ziady A, Sabulski A, Jodele S, Seif AE, Davies SM, Laskin BL, Blackard JT, Rubinstein JD: BK Polyomavirus Genotype IV Isolates from Virus-Specific T-cell Therapy Recipients. Microbiol Resour Announc 14(10): e0062525, Oct 2025.
Im C, Raduski AR, Mills LJ, Bhattarai KR, Mobley RJ, Barnett KR, Lu Z, Liao K, Anderson N, Johnson RA, Langer E, Hooten AJ, Seif AE, Bernt KM, Tsang M, Mamou BA, Gil-de-Gomez L, Wolfson JA, Friedman DN, Shukla N, Klesse LJ, Marcotte EL, Ji L, Dang A, Lagie J, Chiang CWK, de Smith A, Wiesel's JL, DeWan A, Ma X, Metayer C, Wang Z, Nelson HH, Pankratz N, Yang T, Basu S, Turcotte LM, Yang JJ, Savic D, Scheurer ME, Speector LG: Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci. Nat Commun 16(1): 8974, Oct 2025.
Zheng DJ, Hettinger G, Bender JD, Boulter AC, Cao L, Elgarten CW, Fisher BT, Gathers C, Huang Y-SV, Ko J, Leger KJ, Li Y, Myers R, Narayan HK, Ortiz J, Seif AE, Vasileiadi E, Aplenc R, Getz KD: National Trends in Dexrazoxane and Cardiovascular Health Care Utilization for Children With Acute Myeloid Leukemia. JAMA Oncol Page: e254365, Oct 2025 Notes: Online ahead of print.
Ortiz J, Seif AE, States LJ, Mehta S, MacFarland SP, Zheng DJ: Gemcitabine and oxaliplatin induced veno-occlusive disease in a pediatric patient with multiply relapsed germ cell tumor. Pediatric Blood Cancer 72(10): e31945, Oct 2025.
Seif AE, McDonough SL, Becker-Haimes EM, Oranges KE, Clerico D, Hartman J, Rodock K, Schwartz LA, Elgarten CW, Myers RM, Puszczynski RO, Rheingold SR, Stern JW, Jubelirer TF, Armideo EA, Evageliou NF, Randall RJ, Bernt KM, Reilly AF, Tasian SK, Diamant RK, Fisher BT, Getz KD, Aplenc R: AML Care at Home: an evidence-based toolkit to personalize the care setting for recovery from pediatric AML chemotherapy. JCO Oncol Pract Page: OP2500314, September 2025 Notes: Online ahead of print. doi: 10.1200/OP-25-00314.
Walder TA*, Odegard EA*, Meeds HL, Kleiboeker SB, Ziady A, Sabulski A, Jodele S, Seif AE, Davies SM, Laskin BL, Blackard JT: Single Nucleotide Polymorphisms within the BK Polyomavirus Non-Coding Control Region are Genotype-Associated. Microbiol Spectrum 13(8): e0049425, Aug 2025.
Zheng DJ, Hettinger G, Aftandilian C, Bona K, Caywood EH, Collier AB, Elgarten CW, Gathers C, Ghosh T, Gramatges MM, Henry M, Huang Y-SV, Li Y, Lotterman C, Maloney K, Mian A, Miller TP, Modi A, Mody R, Morgan E, Myers R, Newman H, Ortiz J, Seif AE, Smith C, Stokke J, Wang X, Winick N, Wilkes JJ, Wong V, Aplenc R, Getz KD: Real-world generalizability of clinical trial cytomolecular risk in pediatric acute myeloid leukemia: a report from the REAL-AML cohort. J Natl Cancer Inst Page: djaf234, Aug 2025 Notes: Online ahead of print.
Gil-de-Gomez L, Mattei JJ, Lee JH, Grupp SA, Reid GSD*, Seif AE*: CD4+ T Cells Mediate Dendritic Cell Licensing to Promote Multi-Antigen Anti-Leukemic Immune Response. Cancer Medicine 14(1): e70508, Jan 2025.
