Leslie Raffini, M.D., M.S.C.E.
Professor of Pediatrics (Hematology) at the Children's Hospital of Philadelphia
Director, Hemostasis and Thrombosis Center, Children's Hospital of Philadelphia, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Hematology
The HUB for Clinical Collaboration
3500 Civic Center Blvd
13th Floor
Philadelphia, PA 19104
Division of Hematology
The HUB for Clinical Collaboration
3500 Civic Center Blvd
13th Floor
Philadelphia, PA 19104
Office: 267 426-5029
Email:
raffini@email.chop.edu
raffini@email.chop.edu
Education
B.S. (Molecular Biology)
University of Wisconsin, 1991.
M.D.
University of Wisconsin, 1996.
M.S.C.E (Clinical Epidemiology)
University of Pennsylvania, 2005.
Permanent linkB.S. (Molecular Biology)
University of Wisconsin, 1991.
M.D.
University of Wisconsin, 1996.
M.S.C.E (Clinical Epidemiology)
University of Pennsylvania, 2005.
Description of Research Expertise
Risk Factors for Thromboembolic Events in ChildrenDescription of Clinical Expertise
Diagnosis and Management of Thromboembolic Events in ChildrenDescription of Other Expertise
Diagnosis and Management of Bleeding Disorders in ChildrenSelected Publications
Wagner K., Raffini L., Whitworth H.: Acute management and bleeding outcomes in pediatric pulmonary embolism: A large, single-center retrospective cohort study. Sem Thromb Hemost online ahead of print, 2026.Goldenberg N, Berkowitz S, Betensky M, Holzhauer S, Ignatovic V, Kiskaddon A, Schaufelberger D, Monagle P, Male C; Antithrombotic Trials Working Party of the ISTH SSC Subcommitte on on Pediatric and Neonatal Thrombosis and Hemostasis: Development of new antithrombotic drugs for children (part 1): guidance from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosi and Hemostasis and the Pedi-ATLAS Group. J Thromb Haemost online ahead of print, 2026.
Dain AS, Li Y, Master S, Bailey C, Vossough A, Ichord R, Raffini L, Getz K, Kwiatkowski JL.: Trends in HU utilization and cerebrovascular outcomes before and after publication of the 2014 National Heart, Lung, and Blood Institute sickle cell disease guidelines. Pediatr Hematol Oncol 43(2): 39-46, 2026.
Huibonhoa R, Raffini L, Sochet A, Chiusolo F, Nossair F, Tripathi S, Faustino E.: Perceived relative clinical significance of the risks of venous thromboembolism and bleeding from pharmacologic thromboprophylaxis in children: an international survey of pediatric providers: communication from the ISTH-SSC Subcommittee on pediatric and neonatal thrombosis and hemostasis. J Thromb Haemost 24(4): 1548-1558, 2026.
Whitworth H, Branchford B, Faustino E, Huibonhoa R, Kulkarni K, Raffini L, Rajpurkar M, Rodriguez V, Sochet A, Valenti G, Zimowski K, Jaffray J.: Research priorities for pediatric venous thromboembolism prevention: communication from the ISTH SSC Subcommittee on pediatric and neonatal hemostasis and thrombosis. J Thromb Haemost 24(5): 1906-1922, 2026.
Whitworth H, Betensky M, Bhat R, Al-Ghafry M, Amankwah E, Biss T, Brandao L, Chan A, Holzhaur S, Kiskaddon A, Klaassen I, Monagle M, Raffini L, Revel-Vilk S, Sharathkumar A, Sochet A, van Ommen H, Male C, Goldenberg N.: Systematic review on the design and methodology of the pediatric direct oral anticoagulant clinical trials for thrombosis prevention: communication from the ISTH SSC Subcommitte on Pediatric and Neonatal Thrombosis and Hemostasis. J Thromb Haemost 24(6): 2303-2316, 2026.
Betensky M, Azzam M, Bercovitz R, Bhat R, Biss T, Branchford B, Brandoa L, Chan A, Faustino E, Hamarsha Q, Jaffray J, Jones S, Kawtharany H, Kerlin B, Khawandi J, Krider G, Kucine N, Kumar R, Male C, Monagle M, Pelland-Marcotte M, Raffini L, Rauliji C, Sartain S, Takemoto C, Tarango C, van Ommen H, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Mustafa R. : ASH ISTH 2026 guidelines for anticoagulant prophylaxis of pediatric patients at risk of venous thromboembolism. Blood Adv online ahead of print, 2026.
Whitworth H, Wagner K, Zelinski A, DiCocco E, Goodwin Davies A, Jordan R, Higginbotham M, O'Byrne M, Bailey L, Raffini L, Rajpurkar M: A novel Computable phENotype To Identify Pulmonary Embolism in chilDrEn: The CENTIPEDE Study. Thromb Res online ahead of print, 2025.
Whitworth H, Raffini L: The balancing act after pediatric venous thromboembolism. Blood Adv 9(15): 3905-3906, 2025.
Choaib A, AlKhader A, Azzam M, Kawtharany H, Betensky M, Raffini L, Bercovitz R, Besely S, Monagle P, Mustafa R: Updating clinical guidelines with limited evidence:case study of ASH/ISTH pediatric VTE treatment guidelines. Blood Adv 9(20): 5347-5349, 2025.