Leslie Raffini, M.D., M.S.C.E.
Professor of Pediatrics at the Children's Hospital of Philadelphia
Director, Hemostasis and Thrombosis Center, Children's Hospital of Philadelphia, University of Pennsylvania
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Hematology
3501 Civic Center Blvd
CTRB 11th Floor
Philadelphia, PA 19104
Division of Hematology
3501 Civic Center Blvd
CTRB 11th Floor
Philadelphia, PA 19104
Office: 267 426-5029
Email:
raffini@email.chop.edu
raffini@email.chop.edu
Education:
B.S. (Molecular Biology)
University of Wisconsin, 1991.
M.D.
University of Wisconsin, 1996.
M.S.C.E (Clinical Epidemiology)
University of Pennsylvania, 2005.
Permanent linkB.S. (Molecular Biology)
University of Wisconsin, 1991.
M.D.
University of Wisconsin, 1996.
M.S.C.E (Clinical Epidemiology)
University of Pennsylvania, 2005.
Description of Research Expertise
Risk Factors for Thromboembolic Events in ChildrenDescription of Clinical Expertise
Diagnosis and Management of Thromboembolic Events in ChildrenDescription of Other Expertise
Diagnosis and Management of Bleeding Disorders in ChildrenSelected Publications
O’Brien S., Stanek J., Witmer C. Raffini L.: The continued rise of venous thromboembolism across U.S. Children’s Hospitals. Pediatrics in press, 2022.Clark H., Ballester L., Whitworth H., Raffini L., Witmer C.: Prevention of recurrent thrombotic events in children with catheter-associated venous thrombosis. Blood 139(3): 452-60, 2022.
Strong A, March M, Cardinale C, Kim S, Merves J, Whitworth H, Raffini L, Larmas C, Copelvitch L, Hou C, Slater D, Vaccaro C, Watson D, Zackai E, Billheimer J, Hakonarson H.: A novel MBTPS2 variant associated with BRESHECK syndrome impairs sterol-regulated transcription and the endoplasmic reticulum stress response. Am J Med Genet A 188(2): 463-72, 2022.
Bhatt M., Hamilton K., Kulkarni K., Raffini L., Simpson E., Thabane L., Chan A.: A pilot feasibility and safety multicenter trial of administering weight adjusted fixed dose of low molecular weight heparin (enoxaparin) to neonates and children with thrombosis. Med Case Rep Study Protoc 2(2 (e0053)), 2021.
Samelson-Jones B., Guelcher C., Kuhn J., Butler R., Massey G., Guerrera M., Raffini L.: Real-world cost estimates of initiating emicizumab in US patients with haemophilia A. Haemophilia 27(4): 591-98, 2021.
Davila J., Cheng D., Raffini L., Thornburg C., Corrales-Medina F.: Characterizing the use of anticoagulants in children using the American Thrombosis and Hemostasis Network Dataset (ATHNdataset). Thromb Res 197: 84-87, 2021.
Clark H, Ballester L, Whitworth H, Raffini L, Witmer C.: Prevention of recurrent thrombotic events in children with catheter-associated venous thrombosis. Blood online ahead of print, 2021.
Faustino E.V., Shabanova V., Raffini L., Kandil S., Li S., Pinto M., Cholette J., Hanson S., Nellis M., Higgerson R., Silva C., Chima R., Sharathkumar A., Thomas K., McPartland T., Tala J., Spinella P.: Efficacy of early prophylaxis against catheter-associated thrombosis in critically ill children: A phase 2b randomized clinical trial. Crit Care Med 49(3): e235-46, 2021.
Faustino E.V., Raffini L., Cholette J., Hanson S., Pinto M., Li S., Kandil S., Shabanova V., Tala J., McPartland T., Spinella P.: Age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against catheter- associated thrombosis in critically ill children: A post hoc analysis of a Bayesian phase 2b randomized clinical trial. Crit Care Med 49(4): e369-80, 2021.
Mitchel E.B., Rosenbaum S., Gaeta C., Huang J., Raffini L., Balsassano R., Denburg M., Albenberg L.: Venous thromboembolism in pediatric inflammatory bowel disease: a case control study. J Pediatr Gastroenterol Nutr 72(5): 742-47, 2021.