Leslie Raffini, M.D., M.S.C.E.

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Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Hematology
3501 Civic Center Blvd
CTRB 11th Floor
Philadelphia, PA 19104
Office: 267 426-5029
B.S. (Molecular Biology)
University of Wisconsin, 1991.
University of Wisconsin, 1996.
M.S. (Clinical Epidemiology)
University of Pennsylvania, 2005.
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Description of Research Expertise

Risk Factors for Thromboembolic Events in Children

Description of Clinical Expertise

Diagnosis and Management of Thromboembolic Events in Children

Description of Other Expertise

Diagnosis and Management of Bleeding Disorders in Children

Selected Publications

Bhatt M., Hamilton K., Kulkarni K., Raffini L., Simpson E., Thabane L., Chan A.: A pilot feasibility and safety multicenter trial of administering weight adjusted fixed dose of low molecular weight heparin (enoxaparin) to neonates and children with thrombosis. Med Case Rep Study Protoc 2(2 (e0053)), 2021.

Davila J., Cheng D., Raffini L., Thornburg C., Corrales-Medina F.: Characterizing the use of anticoagulants in children using the American Thrombosis and Hemostasis Network Dataset (ATHNdataset). Thromb Res 197: 84-87, 2021.

Faustino E.V., Shabanova V., Raffini L., Kandil S., Li S., Pinto M., Cholette J., Hanson S., Nellis M., Higgerson R., Silva C., Chima R., Sharathkumar A., Thomas K., McPartland T., Tala J., Spinella P.: Efficacy of early prophylaxis against catheter-associated thrombosis in critically ill children: A phase 2b randomized clinical trial. Crit Care Med 49(3): e235-46, 2021 Notes: Online ahead of print.

Faustino E.V., Raffini L., Cholette J., Hanson S., Pinto M., Li S., Kandil S., Shabanova V., Tala J., McPartland T., Spinella P.: Age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against catheter- associated thrombosis in critically ill children: A post hoc analysis of a Bayesian phase 2b randomized clinical trial. Crit Care Med online first, 2021.

Mitchel E.B., Rosenbaum S., Gaeta C., Huang J., Raffini L., Balsassano R., Denburg M., Albenberg L.: Venous thromboembolism in pediatric inflammatory bowel disease: a case control study. J Pediatr Gastroenterol Nutr online ahead of print, 2021.

Witmer C., Raffini L.: Treatment of venous thromboembolism in pediatric patients. Blood 135(5): 335-43, 2020.

Bedoya M., Raffini L., Durand R., Acord M., Srinivasan A., Krishnamurthy G., Vatsky S., Keller M., Cahill A.: Implantable venous access devices in children with severe hemophilia: A tertiary pediatric institutional experience. Pediatr Radiol 50(8): 1148-55, 2020.

McCary E., Guelcher C., Kuhn J., Ballester L., Butler R., Guerrera M., Massey G., Raffini L. : Real world use of emicizumab in patients with hemophilia with and without inhibitors. Haemophilia 26(4): 631-36, 2020.

George L., Ragni M., Rasko J., Raffini L., Samelson-Jones B., Hazbon M., Runowski A., Wellman J., Wachtel K, Anguela X., Kuranda K., Mingozzi F., High K.: Long-term follow-up for the first in human intravascular delivery of AAV for gene transfer: AAV2-hFIX16 for severe hemophilia B. Mol Therapy 28(9): 2073-2082, 2020.

Samelson-Jones B., Acord M., Raffini L.: Bivalirudin during thrombolysis with catheter directed tPA in a heparin refractory patient: A case report. Ped Blood Cancer 67(2): e28518, 2020.

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Last updated: 03/16/2021
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