Stephen J. Bagley, MD, MSCE

faculty photo
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
10th Floor, South Pavilion
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215-614-1858
Fax: 215-662-2432
BA (Biology)
University of Pennsylvania, 2007.
University of Pennsylvania, 2011.
MSCE (Clinical Epidemiology )
University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics , 2018.
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Description of Clinical Expertise

Primary brain tumors, brain metastases, leptomeningeal disease

Description of Research Expertise

I am a medical oncologist with expertise in malignancies of the central nervous system. My research interests include immunotherapeutic approaches to glioblastoma and use of circulating biomarkers for CNS tumors.

Selected Publications

Bagley SJ, Nabavizadeh SA, Mays JJ, Till JE, Ware JB, Levy S, Sarchiapone W, Hussain J, Prior T, Guiry S, Christensen T, Yee SS, Nasrallah MP, Morrissette JJD, Binder ZA, O'Rourke DM, Cucchiara AJ, Brem S, Desai AS, Carpenter EL: Clinical Utility of Plasma Cell-Free DNA in Adult Patients With Newly Diagnosed Glioblastoma: A Pilot Prospective Study. Clin Cancer Res 26(2): 397-407, Jan 2020.

Bagley SJ, Desai AS, Nasrallah MP, and O'Rourke DM : Immunotherapy and Response Assessment in Malignant Glioma: Neuro-oncology Perspective. Top Magn Reson Imaging 29(2): 95-102, April 2020.

Bagley SJ and O'Rourke DM: Clinical Investigation of CAR T Cells for Solid Tumors: Lessons Learned and Future Directions. Pharmacol Ther Page: 205:107419. Jan 2020 Notes: doi: 10.1016/j.pharmthera.2019.107419.

Lee EQ, Weller M, Sul J, Bagley SJ, Sahebjam S, van den Bent M, Ahluwalia M, Campian JL, Galanis E, Gilbert MR, Holdhoff M, Lesser GJ, Lieberman FS, Mehta MP, Penas-Prado M, Schreck KC, Strowd RE, Vogelbaum MA, Walbert T, Chang SM, Nabors LB, Grossman S, Reardon DA, Wen PY: Optimizing Eligibility Criteria and Clinical Trial Conduct to Enhance Clinical Trial Participation for Primary Brain Tumor Patients. Neuro Oncol 22(5): 601-612, May 2020.

Bagley Stephen J, Desai Arati S, Linette Gerald P, June Carl H, O'Rourke Donald M: CAR T Cell Therapy for Glioblastoma: Recent Clinical Advances and Future Challenges. Neuro Oncology 20(11): 1429-1438, Oct 2018.

Nabavizadeh SA, Ware JB, Guiry S, Nasrallah MP, Mays JJ, Till JE, Hussain J, Abdalla A, Yee SS, Binder ZA, O'Rourke DM, Brem S, Desai AS, Wolf R, Carpenter EL, Bagley SJ: Imaging and Histopathologic Correlates of Plasma Cell-Free DNA Concentration and Circulating Tumor DNA in Adult Patients With Newly Diagnosed Glioblastoma. Neurooncol Adv 2(1): vdaa016, Jan 2020.

Bagley SJ, Hwang WT, Brem S, Linette GP, O'Rourke DM, and Desai AS: RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma. Journal of Neuro-Oncology 141(1): 95-102, January 2019.

Akbari H, Rathore S, Bakas S, Nasrallah MP, Shukla G, Mamourian E, Rozycki M, Bagley SJ, Rudie JD, Flanders AE, Dicker AP, Desai AS, O'Rourke DM, Brem S, Lustig R, Mohan S, Wolf RL, Bilello M, Martinez-Lage M, Davatzikos C: Histopathology-validated Machine Learning Radiographic Biomarker for Noninvasive Discrimination Between True Progression and Pseudo-Progression in Glioblastoma. Cancer 126(11): 2625-2636, Jun 2020.

Davatzikos C, Barnholtz-Sloan JS, Bakas S, Colen R, Mahajan A, Quintero CB, Font JC, Puig J, Jain R, Sloan AE, Badve C, Marcus DS, Choi YS, Lee SK, Chang JH, Poisson LM, Griffith B, Dicker AP, Flanders AE, Booth TC, Rathore S, Akbari H, Sako C, Bilello M, Shukla G, Kazerooni AF, Brem S, Lustig R, Mohan S, Bagley S, Nasrallah M, O'Rourke DM: AI-based Prognostic Imaging Biomarkers for Precision Neurooncology: The ReSPOND Consortium. Neuro Oncol 22(6): 886-888, Jun 2020.

Henderson F Jr, Brem S, O'Rourke DM, Nasrallah M, Buch VP, Young AJ, Doot RK, Pantel A, Desai A, Bagley SJ, Nabavizadeh SA: 18 F-Fluciclovine PET to Distinguish Treatment-Related Effects From Disease Progression in Recurrent Glioblastoma: PET Fusion With MRI Guides Neurosurgical Sampling. Neurooncol Pract 7(2): 152-157, Mar 2020.

Binder Zev A, Thorne Amy Haseley, Bakas Spyridon, Wileyto E Paul, Bilello Michel, Akbari Hamed, Rathore Saima, Ha Sung Min, Zhang Logan, Ferguson Cole J, Dahiya Sonika, Bi Wenya Linda, Reardon David A, Idbaih Ahmed, Felsberg Joerg, Hentschel Bettina, Weller Michael, Bagley Stephen J, Morrissette Jennifer J D, Nasrallah MacLean P, Ma Jianhui, Zanca Ciro, Scott Andrew M, Orellana Laura, Davatzikos Christos, Furnari Frank B, O'Rourke Donald M: Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development. Cancer cell 34(1): 163-177.e7, Jul 2018.

Makhlin I, Salinas RD, Zhang D, Jacob F, Ming GL, Song H, Saxena D, Dorsey JF, Nasrallah MP, Morrissette JJ, Binder ZA, O'Rourke DM, Desai AS, Brem S, Bagley SJ: Clinical Activity of the EGFR Tyrosine Kinase Inhibitor Osimertinib in EGFR-mutant Glioblastoma. CNS Oncol 8(3), Nov 2019.

Struve N, Binder ZA, Stead LF, Brend T, Bagley SJ, Faulkner C, Ott L, Müller-Goebel J, Weik AS, Hoffer K, Krug L, Rieckmann T, Bußmann L, Henze M, Morrissette JJD, Kurian KM, Schüller U, Petersen C, Rothkamm K, O Rourke DM, Short SC, Kriegs M: EGFRvIII Upregulates DNA Mismatch Repair Resulting in Increased Temozolomide Sensitivity of MGMT Promoter Methylated Glioblastoma. Oncogene 39(15): 3041-3055, Apr 2020.

Fathi Kazerooni A, Akbari H, Shukla G, Badve C, Rudie JD, Sako C, Rathore S, Bakas S, Pati S, Singh A, Bergman M, Ha SM, Kontos D, Nasrallah M, Bagley SJ, Lustig RA, O'Rourke DM, Sloan AE, Barnholtz-Sloan JS, Mohan S, Bilello M, Davatzikos C: Cancer Imaging Phenomics via CaPTk: Multi-Institutional Prediction of Progression-Free Survival and Pattern of Recurrence in Glioblastoma. JCO Clin Cancer Inform 4: 234-244, Mar 2020.

Nabavizadeh SA, Akbari H, Ware JB, Nasrallah M, Guiry S, Bagley SJ, Desai A, Levy S, Sarchiapone W, Prior T, Detre J, Wolf RL, O'Rourke DM, Brem S, Davatzikos C. : Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MRI Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma. Scientific Reports 9(1): 8747, Jun 2019.

Bagley SJ, Schwab RD, Nelson E, Viaene AN, Binder AZ, Lustig RA, O’Rourke DM, Brem S, Desai AS, and Nasrallah MP: Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma. Journal of Neurooncology 141(2): 421-429, January 2019.

Bagley SJ, Carpenter EL: Plasma cfDNA in Glioblastoma - Response. Clinical Cancer Research 26(9): 2276, May 2020.

Kluger BM, Ney DE, Bagley SJ, Mohile N, Taylor LP, Walbert T, Jones CA.: Top Ten Tips Palliative Care Clinicians Should Know When Caring for Patients with Brain Cancer. J Palliat Med. 23(3): 415-421, Mar 2020.

Bagley SJ, Kothari S, Aggarwal C, Bauml JM, Alley EW, Evans TL, Kosteva JA, Ciunci CA, Gabriel PE, Thompson JC, Stonehouse-Lee S, Sherry VE, Gilbert E, Eaby-Sandy B, Mutale F, DiLullo G, Cohen RB, Vachani A, Langer CJ: Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer. Lung cancer 106: 1-7, Apr 2017.

Bagley SJ: Role of temozolomide in the treatment of cancers involving the central nervous system. Commentary. Oncology 32(11): 569, Nov 2018.

Thompson JC, Yee SS, Troxel AB, Savitch SL, Fan R, Balli D, Lieberman DB, Morrissette JD, Evans TL, Bauml J, Aggarwal C, Kosteva JA, Alley E, Ciunci C, Cohen RB, Bagley S, Stonehouse-Lee S, Sherry VE, Gilbert E, Langer C, Vachani A, Carpenter EL: Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA. Clinical Cancer Research 22(23): 5772-5782, Dec 2016.

Bagley SJ, Dhopeshwarkare, Narayan V, Meropol NJ, Mamtani R, and Boursi B. : Impact of antibiotics on overall survival in patients with advanced non-small cell lung cancer and melanoma treated with first-line immune checkpoint inhibition. J Clin Oncol 37(suppl; abstr e20643): e20643, Jun 2019 Notes: "Poster Presentation"

Bagley SJ, Talento S, Mitra N, Meropol NJ, Cohen RB, Langer CJ, and Vachani A: Comparative effectiveness of carboplatin-pemetrexed with vs without bevacizumab for advanced non-squamous non-small cell lung cancer. J Natl Compr Canc Netw 17(5): 469-477, May 2019.

Rathore S, Bakas S, Nasrallah MP, Bagley SJ, Akbari H, Ha SM, Mamourian EC, Watt C, and Davatzikos C. : Non-invasive determination of the O6-methylguanine-DNA-methyltransferase promoter methylation status in glioblastoma using magnetic resonance imaging. Journal of Clinical Oncology 36(15_suppl), May 2018.

Aggarwal C, Davis CW, Mick R, Thompson J, Ahmed S, Jeffries S, Bagley SJ, Gabriel P, Evans TL, Bauml JM, Ciunci C, Alley E, Morrissette J, Cohen RB, Carpenter E, and Langer CJ. : Influence of TP53 mutations on survival and transformation to small cell lung cancer in patients with EGFR-mutant advanced non-small cell lung cancer. JCO Precis Oncol Aug 2018 Notes: 2018:10.1200/PO.18.00107.doi: 10.1200/PO.18.00107. Epub 2018 Aug 31.

Weiss JM, Bagley S, Hwang WT, Bauml J, Olson JG, Cohen RB, Hayes DN, Langer C.: Capecitabine and lapatinib for the first-line treatment of metastatic/recurrent head and neck squamous cell carcinoma. Cancer 122(15): 2350-5, Aug 2016.

Rosenberg SA, Baschnagel AM, Bagley SJ, Housri N.: Strategies for Translating Evidence-Based Medicine in Lung Cancer into Community Practice. Current Oncology Reports 19(1): 5, Jan 2017.

Bagley Stephen J, Vitale Steven, Zhang Suhong, Aggarwal Charu, Evans Tracey L, Alley Evan W, Cohen Roger B, Langer Corey J, Blair Ian A, Vachani Anil, Whitehead Alexander S: Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clinical Lung Cancer 18(2): e143-e149, Mar 2017.

Bagley SJ, Bauml JM, Langer CJ.: PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer. Clinical Advances in Hematology & Oncology 13(10): 676-83, Oct 2015.

Bagley SJ, Sehgal AR, Gill S, Frey NV, Hexner EO, Loren AW, Mangan JK, Porter DL, Stadtmauer EA, Reshef R, Luger SM.: Acute cholecystitis is a common complication after allogeneic stem cell transplantation and is associated with the use of total parenteral nutrition. Biology of Blood and Marrow Transplantation 21(4): 768-71, Apr 2015.

Bagley SJ, Reynolds WW, Nelson RM.: Is a "wage-payment" model for research participation appropriate for children? Pediatrics 119(1): 46-51, Jan 2007.

Bagley SJ, Kosteva JA, Evans TL, and Langer CJ. : Immune thrombocytopenia exacerbated by nivolumab in a patient with non-small cell lung cancer. Cancer Treatment Research and Communications 6: 20-23, Feb 2016 Notes:

Katz Sharyn I, Hammer Mark, Bagley Stephen J, Aggarwal Charu, Bauml Joshua M, Thompson Jeffrey C, Nachiappan Arun C, Simone Charles B, Langer Corey J: Radiologic Pseudoprogression during Anti-PD-1 Therapy for Advanced Non-Small Cell Lung Cancer. Journal of Thoracic Oncology 13(7): 978-986, Jul 2018.

Tsai Donald E, Bagley Stephen, Reshef Ran, Shaked Abraham, Bloom Roy D, Ahya Vivek, Goldberg Lee, Chung Albert, Debonera Fotini, Schuster Stephen J, Huntington Scott F: The changing face of adult posttransplant lymphoproliferative disorder: Changes in histology between 1999 and 2013. American Journal of Hematology 93(7): 874-881, Jul 2018.

Hammer Mark, Bagley Stephen, Aggarwal Charu, Bauml Joshua, Nachiappan Arun C, Simone Charles B, Langer Corey, Katz Sharyn I: Thoracic Imaging of Non-Small Cell Lung Cancer Treated With Anti-programmed Death Receptor-1 Therapy. Current problems in diagnostic radiology 48(2): 142-147, Mar-Apr 2019.

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Last updated: 02/23/2021
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