Sabrina W. Yum, M.D.

faculty photo
Assistant Professor of Clinical Neurology
Department: Neurology

Contact information
CTRB Rm10008
3501 Civic Center Boulevard
Philadelphia, pa 19104
Office: 215-590-1719
Fax: 215-590-1771
Education:
M.D. (Medicine)
Guangzhou Medical College, 1983.
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Description of Research Expertise

Biology and pathogenesis of connexin mutations associated with Charcot-Marie-Tooth disease, hearing loss
The role of neurofilaments in axonal degeneration
Charcot-Marie-Tooth disease
Muscular Dystrophy
Pediatric neuromuscular disorders
clinical trials in pediatric neuromuscular diseases

Description of Clinical Expertise

Pediatric Neurology
Pediatric Neuromuscular diseases
Charcot-Marie-Tooth disease
Brachial plexopathy, Erb's palsy
Nerve conduction study and EMG
Muscle ultrasound
BOTOX injection for patients with movement disorders and spasticity

Selected Publications

Estilow T, Glanzman AM, Burns J, Harrington A, Cornett KMD, Menezes MP, Shy R, Moroni I, Foscan M, Pagliano E, Pareyson D, Bhandari T, Muntoni F, Laura M, Reilly MM, Finkel RS, Eichinger K, Herrmann DN, Troutman G, Bray P, Halaki M, Shy ME, Yum SW: Balance impairment in pediatric charcot–marie–tooth disease. Muscle & Nerve 60(3), Sep 2019.

Kim AG, Upah SA, Brandsema JF, Yum SW, Blinman TA: Thoracoscopic thymectomy for juvenile myasthenia gravis. Pediatr Surg Int 35(5): 603–610, May 2019.

Tao F, Beecham GW, Rebelo AP, Blanton SH, Moran JJ, Lopez-Anido C, Svaren J, Morrow JM, Abreu L, Rizzo D, Kirk CA, Wu X, Feely S, Verhamme C, Sporta MA, Herrmann DN, Day JW, Sumner CJ, Lloyd TE, Li J, Yum SW, Toroni F, Baas F, Choi Byung, Pareyson D, Scherer SS, Reilly MM, Shy ME, Zuchner S, for the inherited Neuropathy Consortium: Variation in SIPA1L2 is correlated with phenotype modification in CMT type 1A. Annals of Neurology 85(3): 316-330, Mar 2019.

Kichula E, Devanarayan P, Glanzman A, Estilow T, Yum SW, Brandsema J. : Motor Outcomes after Clinical Treatment with Nusinersen: A Single-center Experience. Neurology 92 (15 supp), 2019 Notes: Presented in the 2019 American Academy of Neurology Annual Meeting.

Tao F, Beecham GW, Rebelo, AP, Blanton SH, Moran JJ, Lopez-Anido C, Svaren J, Abreu L, Rizzo D, Kirk CA, Wu X, Feely S, Verhamme C, Saporta MA, Herrmann DN, Day JW, Sumner, CJ, Lloyd TE, Li J, Yum SW, Taroni E, Baas F, Choi BO, Pareyson D, Scherer, SS, Reilly MM, Shy ME, Züchner S, the Inherited Neuropathy Consortium.: Modifier Gene Candidates in Charcot-Marie-Tooth Disease Type 1A: A Case-Only Genome-Wide Association Study. Journal of Neuromuscular Diseases 6(2): 201-211, 2019.

Finanger E, | Vandenborne K, Finkel, RS, Lee Sweeney H, Tennekoon, G, Yum SW, Mancini M, Bista P, Nichols A, Liu H, Fretzen A, Donovan JM: Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF- κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy. Journal of Neuromuscular Dis 6(1): 43-54 2019.

Estilow T, Beam M, Nardone M, Glanzman AM, Yum SW: Sensitivity of Clinically Assessed Measures of Balance and Computerized Dynamic Posturography in Pediatric Charcot-Marie-Tooth Disease. Presented in the 2019 Peripheral Nerve Society Meeting 2019.

Finkel R, Vandenborne KHE, Sweeney HL, Finanger E, Tennekoon G, Shieh P, Willcocks, RJ, Walter G, Rooney W, Forbes, SC, Triplett W, Yum SW, Mancini M, MacDougall J, Fretzen A, Bistra P, Nichols A, Donovan J: Edasalonexent, an NF-kB Inhibitor, Slows Longer-Term Disease Progression on Multiple Functional and MRI Assessments Compared to Control Period in 4 to 7-Year Old Patients with Duchenne Muscular Dystrophy Neurology 92 (15 supp), 2019 Notes: Presented in the 2019 American Academy of Neurology Annual Meeting.

Mandarakas MR. Menezes MP. Rose K. Shy R. Eichinger K. Foscan M. Estilow T. Kennedy R. Herbert K. Bray P. Refshauge K. Ryan M. Farrar M. Moroni I. Yum SW. Acsadi G. Finkel R. Shy M. and Burns J.* Sanmaneechai O: Development and validation of the Charcot-Marie-Tooth disease Infant Scale (CMTInfS). Brain 141(12): 3319-3330, December 2018.

Finkel R, Vandenborne KHE, Sweeney HL, Finanger E, Tennekoon G, Shieh P, Willcocks, RJ, Forbes SC, Triplett W, Yum SW, Mancini M, Fretzen A, Donovan J: MoveDMD®: A Composite of MRI T2 of Five Lower Leg Muscles Is Highly Correlated with Timed Function Tests and Functional Status, and Supports Positive Effects of Edasalonexent in 4 to 7-Year Old Patients with Duchenne Muscular Dystrophy. Presented in 23rd International Annual Congress of the World Muscle Society Oct 2018.

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Last updated: 08/25/2019
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