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Jacob Dubroff, MD, PhD
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Associate Professor of Radiology at the Hospital of the University of Pennsylvania
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Active Medical Staff - Radiologist, Chester County Hospital
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Active Radiologist, Penn Presbyterian Medical Center
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Active Radiologist, Pennsylvania Hospital
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Attending Radiologist, Hospital of the University of Pennsylvania
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Department: Radiology
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Graduate Group Affiliations
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- Neuroscience e
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Contact information
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Hospital of the University of Pennsylvania
1f Department of Radiology
2f Division of Nuclear Imaging and Therapy
1a 3400 Spruce Street
30 1 Silverstein
Philadelphia, PA 19104
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1f Department of Radiology
2f Division of Nuclear Imaging and Therapy
1a 3400 Spruce Street
30 1 Silverstein
Philadelphia, PA 19104
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Office: 215-662-3041
32 Fax: 215-349-5843
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32 Fax: 215-349-5843
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Email:
dubroff@upenn.edu
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dubroff@upenn.edu
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Publications
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Education:
21 8 BAS 23 (Biomedical Engineering) c
44 University of Pennsylvania Philadelphia, PA, 1997.
21 7 BA 2d (History and Sociology of Science) c
44 University of Pennsylvania Philadelphia, PA, 1997.
21 8 PhD 19 (Neuroscience) c
45 SUNY Upstate Medical University Syracuse, NY, 2006.
21 7 MD 15 (Medicine) c
45 SUNY Upstate Medical University Syracuse, NY, 2006.
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Permanent link21 8 BAS 23 (Biomedical Engineering) c
44 University of Pennsylvania Philadelphia, PA, 1997.
21 7 BA 2d (History and Sociology of Science) c
44 University of Pennsylvania Philadelphia, PA, 1997.
21 8 PhD 19 (Neuroscience) c
45 SUNY Upstate Medical University Syracuse, NY, 2006.
21 7 MD 15 (Medicine) c
45 SUNY Upstate Medical University Syracuse, NY, 2006.
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32 SPECT Brain Imaging of Parkinson's Disease
20 PET/CT Oncologic Imaging
1e PET Myocardial Imaging
1c Radionuclide Therapy
1f General Nuclear Medicine
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41 Molecular Imaging of Neurological and Psychiatric Disease
11 Addiction
1b Cardiac PET Imaging
17 Brain Plasticity
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Description of Clinical Expertise
3c PET Brain Imaging of Dementia and Epilepsy32 SPECT Brain Imaging of Parkinson's Disease
20 PET/CT Oncologic Imaging
1e PET Myocardial Imaging
1c Radionuclide Therapy
1f General Nuclear Medicine
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Description of Other Expertise
25a Dr. Dubroff is clinician scientist who uses Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography to better understand the molecular mechanisms of drug abuse, including nicotine dependence and opioid use disorder, as well as neurodegenerative disease, including Parkinson's and Alzheimer's diseases. He collaborates with investigators in the Departments of Psychiatry and Neurology. His studies are supported by the National Institute of Drug Abuse (NIDA), the National Heart, Lung, and Blood Institute (NHLBI), the Michael J. Fox Foundation, and industry.65
Description of Research Expertise
2a Neuroreceptor PET Imaging41 Molecular Imaging of Neurological and Psychiatric Disease
11 Addiction
1b Cardiac PET Imaging
17 Brain Plasticity
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1d1 Duong MT, Das SR, Khandelwal P, Vizcarra JA, Li Y, Xie L, Yushkevich PA, Shaw LM, Dubroff JG, Parkinson’s Progression Markers Initiative, Siderowf AD, Wolk DA, Nasrallah IM: Discordance of dopaminergic dysfunction and subcortical atrophy by α-synuclein status in sporadic and genetic Parkinson’s Disease. Movement Disorders Jan 2026 Notes: doi: 10.1002/mds.70186. Online ahead of print.
16b McKinstrey D, Shi Z, Ramos-Rolón AP, Phillips J, Das S, Li C, Hager NM, Pond T, Kranzler HR, Dubroff JG, Nasrallah IM, Wiers CE: Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose. Addiction Neuroscience Jan 2026 Notes: accepted.
127 Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Schmitz A, Li EJ, Schubert EK, Mach RH, and Kranzler HR: [11C]Carfentanil PET Whole-Body Imaging of Mu-Opioid Receptors: A First In-Human Study. J Nucl Med 66(7): 1112-1118, Jul 2025.
19f M Muller FM, Li EJ, Daube-Witherspoon ME, Pantel AR, Wiers CE, Dubroff JG, Vanhove C, Vandenberghe S, and Karp JS: Impact of Deep Learning Denoising on Kinetic Modelling for Low-Dose Dynamic PET: Application to Single- and Dual-Tracer Imaging Protocols. Eur J Nucl Med Mol Imaging. Mar 2025 Notes: https://doi.org/10.1007/s00259-025-07182-6.
154 Hsieh CJ, Hou C, Lee H, Tomita C, Schmitz A, Plakas K, Dubroff JG, Mach RH: Total-body imaging of mu-opioid receptors with [11C]carfentanil in non-human primates. Eur J Nucl Med Mol Imaging. 51(11): 3273-3283, Sep 2024 Notes: DOI: 10.1007/s00259-024-06746-2.
122 Wetherill RR and Dubroff J: Reply: Molecular Imaging of Pulmonary Inflammation: Claiming That Vaping Is More Harmful Than Smoking Is Unsupported. J Nucl Med 64(6): 995, Jun 2023 Notes: doi: 10.2967/jnumed.123.265570.
17f Wetheril RR, Doot RK, Young AJ, Lee H, Schubert EK, Wiers CE, Leone FT, Mach RH, Kranzler HR, Dubroff JG: Using 18F-NOS PET Imaging to Measure Pulmonary Inflammation in Electronic and Combustible Cigarette Users: A Pilot Study. J Nucl Med 64(5): 797-802, May 2023 Notes: doi: 10.2967/jnumed.122.264529.
d5 Rojulpote C, Bhattaru A, Jean C, Patel V, Vidula M, Selvaraj S, Chandra A, Dubroff J, Peyster E, Clancy C, Patterson K, Marchlinski F, Rossman M, Goldberg L, and Bravo P ce : Effect of Timing, Immunotherapy, and Biopsy-Status in Monitoring Therapy Response in Suspected Cardiac Sarcoidosis. JACC: Cardiovascular Imaging 15(11): 1944-1955, Oct 2022.
1b1 Love T, Shabalin A, Kember R, Docherty A, Zhou H, Koppelmans V, Gelernter J, Baker A, Hartwell E, Dubroff J, Zubieta JK, and Kranzler HR: Unique and Joint Associations of Polygenic Risk for Major Depression and Opioid Use Disorder with Endogenous Opioid System Function. Neuropsychopharmacology 47(10): 1784-90, Sep 2022 Notes: doi: 10.1038/s41386-022-01325-1.
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Selected Publications
1e9 Li X, Young AJ, Shi Z, Byanyima J, Vesslee S, Reddy R, Pond T, Elliott M, Reddy R, Doot RK, van der Veen J-W, Kranzler HR, Nanga RPR, Dubroff JG, Wiers CE: Pharmacokinetic effects of a single dose nutritional ketone ester supplement on brain glucose and ketone metabolism in alcohol use disorder. Psychiatry Research: Neuroimaging. (eds.). 357(112154), Apr 2026 Notes: doi: 10.1016/j.pscychresns.2026.112154.1d1 Duong MT, Das SR, Khandelwal P, Vizcarra JA, Li Y, Xie L, Yushkevich PA, Shaw LM, Dubroff JG, Parkinson’s Progression Markers Initiative, Siderowf AD, Wolk DA, Nasrallah IM: Discordance of dopaminergic dysfunction and subcortical atrophy by α-synuclein status in sporadic and genetic Parkinson’s Disease. Movement Disorders Jan 2026 Notes: doi: 10.1002/mds.70186. Online ahead of print.
16b McKinstrey D, Shi Z, Ramos-Rolón AP, Phillips J, Das S, Li C, Hager NM, Pond T, Kranzler HR, Dubroff JG, Nasrallah IM, Wiers CE: Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose. Addiction Neuroscience Jan 2026 Notes: accepted.
127 Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Schmitz A, Li EJ, Schubert EK, Mach RH, and Kranzler HR: [11C]Carfentanil PET Whole-Body Imaging of Mu-Opioid Receptors: A First In-Human Study. J Nucl Med 66(7): 1112-1118, Jul 2025.
19f M Muller FM, Li EJ, Daube-Witherspoon ME, Pantel AR, Wiers CE, Dubroff JG, Vanhove C, Vandenberghe S, and Karp JS: Impact of Deep Learning Denoising on Kinetic Modelling for Low-Dose Dynamic PET: Application to Single- and Dual-Tracer Imaging Protocols. Eur J Nucl Med Mol Imaging. Mar 2025 Notes: https://doi.org/10.1007/s00259-025-07182-6.
154 Hsieh CJ, Hou C, Lee H, Tomita C, Schmitz A, Plakas K, Dubroff JG, Mach RH: Total-body imaging of mu-opioid receptors with [11C]carfentanil in non-human primates. Eur J Nucl Med Mol Imaging. 51(11): 3273-3283, Sep 2024 Notes: DOI: 10.1007/s00259-024-06746-2.
122 Wetherill RR and Dubroff J: Reply: Molecular Imaging of Pulmonary Inflammation: Claiming That Vaping Is More Harmful Than Smoking Is Unsupported. J Nucl Med 64(6): 995, Jun 2023 Notes: doi: 10.2967/jnumed.123.265570.
17f Wetheril RR, Doot RK, Young AJ, Lee H, Schubert EK, Wiers CE, Leone FT, Mach RH, Kranzler HR, Dubroff JG: Using 18F-NOS PET Imaging to Measure Pulmonary Inflammation in Electronic and Combustible Cigarette Users: A Pilot Study. J Nucl Med 64(5): 797-802, May 2023 Notes: doi: 10.2967/jnumed.122.264529.
d5 Rojulpote C, Bhattaru A, Jean C, Patel V, Vidula M, Selvaraj S, Chandra A, Dubroff J, Peyster E, Clancy C, Patterson K, Marchlinski F, Rossman M, Goldberg L, and Bravo P ce : Effect of Timing, Immunotherapy, and Biopsy-Status in Monitoring Therapy Response in Suspected Cardiac Sarcoidosis. JACC: Cardiovascular Imaging 15(11): 1944-1955, Oct 2022.
1b1 Love T, Shabalin A, Kember R, Docherty A, Zhou H, Koppelmans V, Gelernter J, Baker A, Hartwell E, Dubroff J, Zubieta JK, and Kranzler HR: Unique and Joint Associations of Polygenic Risk for Major Depression and Opioid Use Disorder with Endogenous Opioid System Function. Neuropsychopharmacology 47(10): 1784-90, Sep 2022 Notes: doi: 10.1038/s41386-022-01325-1.
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