Jacob Dubroff, MD, PhD

faculty photo
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
Division of Nuclear Medicine and Clinical Molecular Imaging
3400 Spruce Street
1 Silverstein
Philadelphia, PA 19104
Office: 215-662-3041
Fax: 215-349-5843
BAS (Biomedical Engineering)
University of Pennsylvania Philadelphia, PA, 1997.
BA (History and Sociology of Science)
University of Pennsylvania Philadelphia, PA, 1997.
PhD (Neuroscience)
SUNY Upstate Medical University Syracuse, NY, 2006.
MD (Medicine)
SUNY Upstate Medical University Syracuse, NY, 2006.
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Description of Clinical Expertise

PET Brain Imaging of Dementia and Epilepsy
SPECT Brain Imaging of Parkinson's Disease
PET/CT Oncologic Imaging
PET Myocardial Imaging
General Nuclear Medicine
Iodine-131 Radiotherapy for Thyroid Disease
Radium-223 Chloride Radiotherapy for Metastatic Prostate Cancer
Lutetium-177 DOTATATE Radiotherapy for Metastatic Neuroendocrine Cancer

Description of Other Expertise

Dr. Dubroff is clinician scientist who uses Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography to better understand the molecular mechanisms of drug abuse, including nicotine dependence and opioid use disorder, as well as neurodegenerative disease, including Parkinson's and Alzheimer's diseases. He collaborates with investigators in the Departments of Psychiatry and Neurology. His studies are supported by the National Institute of Drug Abuse (NIDA), the National Heart, Lung, and Blood Institute (NHLBI), the Michael J. Fox Foundation, and industry.

Description of Research Expertise

Neuroreceptor PET Imaging
Molecular Imaging of Neurological and Psychiatric Disease
Cardiac PET Imaging
Brain Plasticity

Selected Publications

Kini LG, Thaker AA, Hadar PN, Shinohara RT, Brown MG, Dubroff JG, Davis KA: Quantitative [18F]FDG PET asymmetry features predict long-term seizure recurrence in refractory epilepsy. Epilepsy & Behavior Page: 107714, January 2021 Notes: doi: 10.1016/j.yebeh.2020.107714. Online ahead of print.

Guerraty MA, Rao S, Anjan VY, Szapary H, Mankoff DA, Pryma DA, Rader DJ, and Dubroff JG : The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes Plos One 15(2), Feb 2020 Notes: doi: 10.1371/journal.pone.0228931.

Pantel AR, Viswanath V, Daube-Witherspoon ME, Dubroff JG, Muehllehner G, Parma MJ, Pryma DA, Schubert EK, Mankoff DA, and Karp JS: PennPET Explorer: Human Imaging on a Whole-body Imager. J Nucl Med 61(1): 144-151, Jan 2020 Notes: doi: 10.2967/jnumed.119.231845.

Doot RK, Dubroff JG, Scheuermann JS, Labban KJ, Cai J, Hsieh CJ, Li S, Lee H, Schubert EK, Hou C, Sheffer R, Schmitz A, Xu K, and Mach RH: Validation of gallbladder absorbed radiation dose reduction simulation: Human dosimetry of [18F]fluortriopride. EJNMMI Physics 5(21), Oct 2018 Notes: https://doi.org/10.1186/s40658-018-0219-6.

Booij J, Dubroff J, Pryma D, Yu J, Agarwal R, Lakhani P, and Kuo PH : Diagnostic performance of the visual reading of 123I-ioflupane SPECT images when assessed with or without quantification in patients with movement disorders or dementia. J Nucl Med 58(11): 1821-26, Nov 2017 Notes: DOI: 10.2967/jnumed.116.189266.

Morley J, Cheng G, Dubroff J, Wood S, Wilkinson J, and Duda J: Olfactory impairment predicts underlying dopaminergic deficit in presumed drug-induced Parkinsonism. Movement Disorders Clinical Practice 4(4): 603-6, July/August 2017 Notes: DOI: 10.1002/mdc3.12458.

Akhtar RS, Xie SX, Chen YJ, Rick J, Gross RG, Nasrallah IM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS, Hurtig HI, Siderowf AD, Dubroff JG, and Weintraub D: Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. PLoS One 12(5), May 2017 Notes: doi: 10.1371/journal.pone.0177924.

Dubroff J, Doot R, Falcone M, Schnoll R, Ray R, Tyndale R, Brody A, Hou C, Schmitz A, and Lerman C.: Decreased nicotinic receptor availability in smokers with slow rates of nicotine metabolism J Nucl Med 56(11): 1724-9, Nov 2015 Notes: DOI: 10.2967/jnumed.115.155002

Nayate AP, Dubroff JG, Schmitt JE, Nasrallah I, Kishore R, Mankoff D and Pryma DA: Use of standardized uptake value ratios decreases interreader variability of [18F] florbetapir PET brain scan interpretation. Am J Neuroradiol 36(7): 1237-44, July 2015.

Doty RL, Nsoesie MT, Chung I, Osman A, Pawasarat I, Caulfield J, Hurtig H, Silas J, Dubroff J, Duda JE, Ying GS, Tekeli H, Leon-Sarmiento FE.: Taste function in early stage treated and untreated Parkinson's disease. J Neurol 262(3): 547-57, Mar 2015.

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Last updated: 03/31/2021
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